Blunted cardiac autonomic dynamics to active standing test in postmenopausal women.

Introduction: Although both aging and menopause influence cardiovascular autonomic control, the effect of menopause per se remains unclear. The current study was undertaken to test the hypothesis that post-menopausal women (PMW) have a blunted cardiovascular autonomic adjustment to active standing compared to pre-menopausal women. Thus, we compared the heart rate variability (HRV) indexes from supine (SUP) to orthostatic (ORT) positions among young women (YW), young men (YM), older men (OM), and PMW. Methods: The participants rested for 10 min in SUP and then stood up and remained for 5 min in ORT. ECG was continuously recorded, and R-R time series of about 300 beats were analyzed using linear (spectral analysis) and non-linear (symbolic analysis) methods. The variation from SUP to ORT was calculated (Δ = ORT-SUP) for each HRV index. Results: In SUP, no difference was found for any HRV index among groups. However, Δ0V% and ΔLFn (cardiac sympathetic modulation) were reduced in PWM compared to all groups (OM, YW, and YM), while Δ2UV% and ΔHFn (cardiac vagal modulation) were reduced in PMW than the younger group (YW and YM). No differences were found among the male groups (OM and YM). Discussion: In light of our results, the cardiac autonomic dynamic response to orthostatic stress is blunted in post-menopausal women compared to younger women and older men, a finding that might be influenced not only by aging.

Sex differences in blood pressure regulation during the isometric exercise under heated environment.

In the absence of heat stress, females increase blood pressure (BP) during isometric handgrip exercise due to cardiac output more than total peripheral resistance (TPR) compared to men. Although heat stress seems to blunt BP responses at rest and during handgrip, possible sex differences remained unknown. We hypothesized that BP responses during handgrip under a heated environment (HOT) will be different between men and women. Eight healthy men (29 ± 6 years) and eight women (26 ± 4 years) participated in this study. The experimental protocol was separated into two environmental conditions: HOT (~ 36 °C) and thermoneutral (TC; ~ 24 °C). In both conditions, participants rested for 30 min and performed the handgrip for 3 min. BP, heart rate (HR) stroke volume and cardiac output were continuously recorded, and TPR was calculated (TPR = mean blood pressure (MBP)/cardiac output). HOT reduced BP and TPR at baseline and during handgrip in females as compared to TC, while males showed similar responses in both thermal conditions. HR was higher under HOT in both groups. Cardiac output and stroke volume were not different under HOT compared to TC for females. In males, cardiac output increased at the last minute of handgrip under HOT through augmented HR, because stroke volume was unchanged. In conclusion, the main effect of HOT was to shift downwards BP and total peripheral resistance at rest and during isometric exercise in females. In males, the combination of handgrip and HOT increased cardiac output by augmented HR, whereas BP presented similar responses between thermal conditions during handgrip.