Detalles de la búsqueda
1.
Targeting GLI1 and GLI2 with small molecule inhibitors to suppress GLI-dependent transcription and tumor growth.
Pharmacol Res;
195: 106858, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37473878
2.
Requirements for MRN endonuclease processing of topoisomerase II-mediated DNA damage in mammalian cells.
Front Mol Biosci;
9: 1007064, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36213114
3.
Quinolines and Oxazino-quinoline Derivatives as Small Molecule GLI1 Inhibitors Identified by Virtual Screening.
ACS Med Chem Lett;
13(8): 1329-1336, 2022 Aug 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35978701
4.
A pH-responsive crosslinker platform for antibody-drug conjugate (ADC) targeting delivery.
Chem Commun (Camb);
58(75): 10532-10535, 2022 Sep 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-36043993
5.
Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor.
Int J Mol Sci;
23(16)2022 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36012721
6.
An Intramolecular Hydroaminomethylation-Based Approach to Pyrrolizidine Alkaloids under Microwave-Assisted Heating.
Molecules;
27(15)2022 Jul 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35897934
7.
Survey on the Recent Advances in 4-Hydroxyphenylpyruvate Dioxygenase (HPPD) Inhibition by Diketone and Triketone Derivatives and Congeneric Compounds: Structural Analysis of HPPD/Inhibitor Complexes and Structure-Activity Relationship Considerations.
J Agric Food Chem;
70(23): 6963-6981, 2022 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35652597
8.
Antibacterial alkylguanidino ureas: Molecular simplification approach, searching for membrane-based MoA.
Eur J Med Chem;
231: 114158, 2022 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35168113
9.
A molecular spectroscopy approach for the investigation of early phase ochronotic pigment development in Alkaptonuria.
Sci Rep;
11(1): 22562, 2021 11 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-34799606
10.
The Antimalarial Mefloquine Shows Activity against Mycobacterium abscessus, Inhibiting Mycolic Acid Metabolism.
Int J Mol Sci;
22(16)2021 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-34445239
11.
Targeting non-canonical activation of GLI1 by the SOX2-BRD4 transcriptional complex improves the efficacy of HEDGEHOG pathway inhibition in melanoma.
Oncogene;
40(22): 3799-3814, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33958721
12.
Antibody drug conjugates with hydroxamic acid cargos for histone deacetylase (HDAC) inhibition.
Chem Commun (Camb);
57(7): 867-870, 2021 Jan 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33433550
13.
Pharmacophore-Based Virtual Screening for Identification of Negative Modulators of GLI1 as Potential Anticancer Agents.
ACS Med Chem Lett;
11(5): 832-838, 2020 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32435392
14.
Structure and Bioactive Properties of Novel Textile Dyes Synthesised by Fungal Laccase.
Int J Mol Sci;
21(6)2020 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32192097
15.
Novel textile dye obtained through transformation of 2-amino-3-methoxybenzoic acid by free and immobilised laccase from a Pleurotus ostreatus strain.
Enzyme Microb Technol;
132: 109398, 2020 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-31731976
16.
ErbB2 Targeted Epigenetic Modulation: Anti-tumor Efficacy of the ADC Trastuzumab-HDACi ST8176AA1.
Front Oncol;
9: 1534, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-32039017
17.
Antibody drug conjugates (ADCs) charged with HDAC inhibitor for targeted epigenetic modulation.
Chem Sci;
9(31): 6490-6496, 2018 Aug 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30288233
18.
MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors.
Cell Death Dis;
9(9): 895, 2018 08 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-30166519
19.
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo.
Eur J Med Chem;
157: 368-379, 2018 Sep 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30099257
20.
Avoiding hot-spots in Microwave-assisted Pd/C catalysed reactions by using the biomass derived solvent γ-Valerolactone.
Sci Rep;
8(1): 10571, 2018 07 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30002506