CT and MRI radiomic features of lung cancer (NSCLC): comparison and software consistency.

BACKGROUND: Radiomics is a quantitative approach that allows the extraction of mineable data from medical images. Despite the growing clinical interest, radiomics studies are affected by variability stemming from analysis choices. We aimed to investigate the agreement between two open-source radiomics software for both contrast-enhanced computed tomography (CT) and contrast-enhanced magnetic resonance imaging (MRI) of lung cancers and to preliminarily evaluate the existence of radiomic features stable for both techniques. METHODS: Contrast-enhanced CT and MRI images of 35 patients affected with non-small cell lung cancer (NSCLC) were manually segmented and preprocessed using three different methods. Sixty-six Image Biomarker Standardisation Initiative-compliant features common to the considered platforms, PyRadiomics and LIFEx, were extracted. The correlation among features with the same mathematical definition was analyzed by comparing PyRadiomics and LIFEx (at fixed imaging technique), and MRI with CT results (for the same software). RESULTS: When assessing the agreement between LIFEx and PyRadiomics across the considered resampling, the maximum statistically significant correlations were observed to be 94% for CT features and 95% for MRI ones. When examining the correlation between features extracted from contrast-enhanced CT and MRI using the same software, higher significant correspondences were identified in 11% of features for both software. CONCLUSIONS: Considering NSCLC, (i) for both imaging techniques, LIFEx and PyRadiomics agreed on average for 90% of features, with MRI being more affected by resampling and (ii) CT and MRI contained mostly non-redundant information, but there are shape features and, more importantly, texture features that can be singled out by both techniques. RELEVANCE STATEMENT: Identifying and selecting features that are stable cross-modalities may be one of the strategies to pave the way for radiomics clinical translation. KEY POINTS: • More than 90% of LIFEx and PyRadiomics features contain the same information. • Ten percent of features (shape, texture) are stable among contrast-enhanced CT and MRI. • Software compliance and cross-modalities stability features are impacted by the resampling method.

Microdose lithium improves behavioral deficits and modulates molecular mechanisms of memory formation in female SAMP-8, a mouse model of accelerated aging.

Alzheimer's disease (AD) is the most common neuronal disorder that leads to the development of dementia. Until nowadays, some therapies may alleviate the symptoms, but there is no pharmacological treatment. Microdosing lithium has been used to modify the pathological characteristics of the disease, with effects in both experimental and clinical conditions. The present work aimed to analyze the effects of this treatment on spatial memory, anxiety, and molecular mechanisms related to long-term memory formation during the aging process of a mouse model of accelerated aging (SAMP-8). Female SAMP-8 showed learning and memory impairments together with disruption of memory mechanisms, neuronal loss, and increased density of senile plaques compared to their natural control strain, the senescence-accelerated mouse resistant (SAMR-1). Chronic treatment with lithium promoted memory maintenance, reduction in anxiety, and maintenance of proteins related to memory formation and neuronal density. The density of senile plaques was also reduced. An increase in the density of gamma-aminobutyric acid A (GABAA) and α7 nicotinic cholinergic receptors was also observed and related to neuroprotection and anxiety reduction. In addition, this microdose of lithium inhibited the activation of glycogen synthase kinase-3beta (GSK-3ß), the classical mechanism of lithium cell effects, which could contribute to the preservation of the memory mechanism and reduction in senile plaque formation. This work shows that lithium effects in neuroprotection along the aging process are not related to a unique cellular mechanism but produce multiple effects that slowly protect the brain along the aging process.

The Role of Native T1 and T2 Mapping Times in Identifying PD-L1 Expression and the Histological Subtype of NSCLCs.

We investigated the association of T1/T2 mapping values with programmed death-ligand 1 protein (PD-L1) expression in lung cancer and their potential in distinguishing between different histological subtypes of non-small cell lung cancers (NSCLCs). Thirty-five patients diagnosed with stage III NSCLC from April 2021 to December 2022 were included. Conventional MRI sequences were acquired with a 1.5 T system. Mean T1 and T2 mapping values were computed for six manually traced ROIs on different areas of the tumor. Data were analyzed through RStudio. Correlation between T1/T2 mapping values and PD-L1 expression was studied with a Wilcoxon-Mann-Whitney test. A Kruskal-Wallis test with a post-hoc Dunn test was used to study the correlation between T1/T2 mapping values and the histological subtypes: squamocellular carcinoma (SCC), adenocarcinoma (ADK), and poorly differentiated NSCLC (PD). There was no statistically significant correlation between T1/T2 mapping values and PD-L1 expression in NSCLC. We found statistically significant differences in T1 mapping values between ADK and SCC for the periphery ROI (p-value 0.004), the core ROI (p-value 0.01), and the whole tumor ROI (p-value 0.02). No differences were found concerning the PD NSCLCs.

Monitoring and evaluation of food and nutritional security: a look at the official publications. / Monitoramento e avaliação da segurança alimentar e nutricional: um olhar sobre as publicações oficiais.

Food and Nutrition Security, the legal frameworks to guarantee and enforce the Human Right to Adequate Food and construction of a system to monitor and evaluate progress and setbacks in these processes are the outcome of collective efforts led by social movements, organized civil society and some areas of government. This article examines official Brazilian documents regarding such monitoring and evaluation published from 2003 to 2019. The documentary analysis and contextualization were framed by the dimensions specified in Decree No. 7272/2010. The analysis highlighted the importance of the National Food and Nutrition Security Council (CONSEA), the Interministerial Food and Nutrition Security Chamber (CAISAN) and the Brazilian Food and Nutrition Security Conferences in the construction of monitoring and evaluation mechanisms. The challenges identified in this process stem from inter-sector relations and decentralization of actions, which tend to be weakened in certain political contexts.

A segurança alimentar e nutricional (SAN), os marcos legais para a garantia e exigibilidade do direito humano à alimentação adequada (DHAA) e a construção de um sistema que monitore e avalie os avanços e retrocessos nesses processos são provenientes dos esforços coletivos impulsionados por movimentos sociais, sociedade civil organizada e alguns segmentos governamentais. Este artigo analisa documentos oficiais produzidos nacionalmente e publicados entre 2003 e 2019 na perspectiva de monitoramento e avaliação (M&A), com a realização de análise documental e contextualização fundamentada nas dimensões do Decreto nº 7.272/2010. Como resultado, destaca-se a importância do Conselho Nacional de Segurança Alimentar e Nutricional, da Câmara Interministerial de Segurança Alimentar e Nutricional e das Conferências Nacionais de SAN na construção de mecanismos de M&A. Os desafios destacados nesse processo se relacionam com as articulações intersetoriais e a descentralização das ações, que tendem a se fragilizar, dependendo dos contextos políticos.

ATLANTIC POLLINATION: a data set of flowers and interaction with nectar-feeding vertebrates from the Atlantic Forest.

Flowering plant species and their nectar-feeding vertebrates exemplify some of the most remarkable biotic interactions in the Neotropics. In the Brazilian Atlantic Forest, several species of birds (especially hummingbirds), bats, and non-flying mammals, as well as one lizard feed on nectar, often act as pollinators and contribute to seed output of flowering plants. We present a dataset containing information on flowering plants visited by nectar-feeding vertebrates and sampled at 166 localities in the Brazilian Atlantic Forest. This dataset provides information on 1902 unique interactions among 515 species of flowering plants and 129 species of potential vertebrate pollinators and the patterns of species diversity across latitudes. All plant-vertebrate interactions compiled were recorded through direct observations of visits, and no inferences of pollinators based on floral syndromes were included. We also provide information on the most common plant traits used to understand the interactions between flowers and nectar-feeding vertebrates: plant growth form, corolla length, rate of nectar production per hour in bagged flowers, nectar concentration, flower color and shape, time of anthesis, presence or absence of perceptible fragrance by human, and flowering phenology as well as the plant's threat status by International Union for Conservation of Nature (IUCN) classification. For the vertebrates, status of threat by IUCN classification, body mass, bill or rostrum size are provided. Information on the frequency of visits and pollen deposition on the vertebrate's body is provided from the original source when available. The highest number of unique interactions is recorded for birds (1771) followed by bats (110). For plants, Bromeliaceae contains the highest number of unique interactions (606), followed by Fabaceae (242) and Gesneriaceae (104). It is evident that there was geographical bias of the studies throughout the southeast of the Brazilian Atlantic Forest and that most effort was directed to flower-hummingbird interactions. However, it reflects a worldwide tendency of more plants interacting with birds compared with other vertebrate species. The lack of similar protocols among studies to collect basic data limits the comparisons among areas and generalizations. Nevertheless, this dataset represents a notable effort to organize and highlight the importance of vertebrate pollinators in this hotspot of biodiversity on Earth and represents the data currently available. No copyright or proprietary restrictions are associated with the use of this data set. Please cite this data paper when the data are used in publications or scientific events.

Monitoramento e avaliação da segurança alimentar e nutricional: um olhar sobre as publicações oficiais / Monitoring and evaluation of food and nutritional security: a look at the official publications

Resumo A segurança alimentar e nutricional (SAN), os marcos legais para a garantia e exigibilidade do direito humano à alimentação adequada (DHAA) e a construção de um sistema que monitore e avalie os avanços e retrocessos nesses processos são provenientes dos esforços coletivos impulsionados por movimentos sociais, sociedade civil organizada e alguns segmentos governamentais. Este artigo analisa documentos oficiais produzidos nacionalmente e publicados entre 2003 e 2019 na perspectiva de monitoramento e avaliação (M&A), com a realização de análise documental e contextualização fundamentada nas dimensões do Decreto nº 7.272/2010. Como resultado, destaca-se a importância do Conselho Nacional de Segurança Alimentar e Nutricional, da Câmara Interministerial de Segurança Alimentar e Nutricional e das Conferências Nacionais de SAN na construção de mecanismos de M&A. Os desafios destacados nesse processo se relacionam com as articulações intersetoriais e a descentralização das ações, que tendem a se fragilizar, dependendo dos contextos políticos.

Abstract Food and Nutrition Security, the legal frameworks to guarantee and enforce the Human Right to Adequate Food and construction of a system to monitor and evaluate progress and setbacks in these processes are the outcome of collective efforts led by social movements, organized civil society and some areas of government. This article examines official Brazilian documents regarding such monitoring and evaluation published from 2003 to 2019. The documentary analysis and contextualization were framed by the dimensions specified in Decree No. 7272/2010. The analysis highlighted the importance of the National Food and Nutrition Security Council (CONSEA), the Interministerial Food and Nutrition Security Chamber (CAISAN) and the Brazilian Food and Nutrition Security Conferences in the construction of monitoring and evaluation mechanisms. The challenges identified in this process stem from inter-sector relations and decentralization of actions, which tend to be weakened in certain political contexts.

Breastfeeding and drug use: what is the orientation found in drug package inserts of contraceptives and anti-infective agents? / Amamentação e utilização de medicamentos: qual a orientação presente nas bulas de anticoncepcionais e anti-infecciosos?

This article aims to evaluate the conformity between drug package inserts (DPIs) and evidence-based bibliographic sources regarding the presence of contraindications to the use of contraceptives and anti-infective agents during breastfeeding. Contraceptive and anti-infectives were selected, according to ATC, with the updated record in the ANVISA and present in the bibliographic sources Breastfeeding and Use of Medicines and Other Substances, Medications and Mother's Milk, LactMed®, Micromedex® and UpToDate®. Information was extracted from the DPI "Contraindications" and "Warnings and precautions" sections and compared with the information in the bibliographic sources. The contraindication of the drug during breastfeeding was evaluated. Contraindications were found in the DPIs of five (55.5%) of the nine contraceptives. The contraindication percentage ranged from 0 to 55.5% among the bibliographic sources, depending on the source. The percentage was 46.3% in the DPIs, ranging from 0 to 12.9% in the bibliographic sources for anti-infectives. There is an agreement between the DPIs and the bibliographic sources regarding contraceptives; regarding anti-infectives, the DPIs are more often contraindicated for use during breastfeeding.

O objetivo deste artigo é avaliar a concordância entre bulas e fontes bibliográficas baseadas em evidências científicas quanto à presença de contraindicação do uso de anticoncepcionais e anti-infecciosos durante a amamentação. Foram selecionados medicamentos anticoncepcionais e anti-infecciosos, segundo a ATC, com registro na ANVISA e presentes nas fontes bibliográficas: Manual Amamentação e Uso de Medicamentos e Outras Substâncias, Medications and Mother's Milk, LactMed®, Micromedex® e UpToDate®. As informações foram extraídas das seções "Contraindicações" e "Advertências e precauções" das bulas e comparadas com as informações das fontes. Foi avaliada a presença de informação contraindicando o uso do medicamento durante a amamentação. Em cinco (55,5%) dos nove anticoncepcionais foi verificada contraindicação na bula. Entre as fontes bibliográficas, o percentual variou de 0% a 55,5%, dependendo da fonte. Para os anti-infecciosos, o percentual de contraindicação foi de 46,3% na bula, variando de 0% a 12,9% nas fontes. Existe concordância entre as bulas e as fontes bibliográficas com relação aos anticoncepcionais; no caso dos anti-infecciosos, as bulas apresentam contraindicação para o uso durante a amamentação com mais frequência.

Amamentação e utilização de medicamentos: qual a orientação presente nas bulas de anticoncepcionais e anti-infecciosos? / Breastfeeding and drug use: what is the orientation found in drug package inserts of contraceptives and anti-infective agents?

Resumo O objetivo deste artigo é avaliar a concordância entre bulas e fontes bibliográficas baseadas em evidências científicas quanto à presença de contraindicação do uso de anticoncepcionais e anti-infecciosos durante a amamentação. Foram selecionados medicamentos anticoncepcionais e anti-infecciosos, segundo a ATC, com registro na ANVISA e presentes nas fontes bibliográficas: Manual Amamentação e Uso de Medicamentos e Outras Substâncias, Medications and Mother's Milk, LactMed®, Micromedex® e UpToDate®. As informações foram extraídas das seções "Contraindicações" e "Advertências e precauções" das bulas e comparadas com as informações das fontes. Foi avaliada a presença de informação contraindicando o uso do medicamento durante a amamentação. Em cinco (55,5%) dos nove anticoncepcionais foi verificada contraindicação na bula. Entre as fontes bibliográficas, o percentual variou de 0% a 55,5%, dependendo da fonte. Para os anti-infecciosos, o percentual de contraindicação foi de 46,3% na bula, variando de 0% a 12,9% nas fontes. Existe concordância entre as bulas e as fontes bibliográficas com relação aos anticoncepcionais; no caso dos anti-infecciosos, as bulas apresentam contraindicação para o uso durante a amamentação com mais frequência.

Abstract This article aims to evaluate the conformity between drug package inserts (DPIs) and evidence-based bibliographic sources regarding the presence of contraindications to the use of contraceptives and anti-infective agents during breastfeeding. Contraceptive and anti-infectives were selected, according to ATC, with the updated record in the ANVISA and present in the bibliographic sources Breastfeeding and Use of Medicines and Other Substances, Medications and Mother's Milk, LactMed®, Micromedex® and UpToDate®. Information was extracted from the DPI "Contraindications" and "Warnings and precautions" sections and compared with the information in the bibliographic sources. The contraindication of the drug during breastfeeding was evaluated. Contraindications were found in the DPIs of five (55.5%) of the nine contraceptives. The contraindication percentage ranged from 0 to 55.5% among the bibliographic sources, depending on the source. The percentage was 46.3% in the DPIs, ranging from 0 to 12.9% in the bibliographic sources for anti-infectives. There is an agreement between the DPIs and the bibliographic sources regarding contraceptives; regarding anti-infectives, the DPIs are more often contraindicated for use during breastfeeding.

Temporal changes in the most effective pollinator of a bromeliad pollinated by bees and hummingbirds.

A generalist pollination system may be characterized through the interaction of a plant species with two or more functional groups of pollinators. The spatiotemporal variation of the most effective pollinator is the factor most frequently advocated to explain the emergence and maintenance of generalist pollination systems. There are few studies merging variation in floral visitor assemblages and the efficacy of pollination by different functional groups. Thus, there are gaps in our knowledge about the variation in time of pollinator efficacy and frequency of generalist species. In this study, we evaluated the pollination efficacy of the floral visitors of Edmundoa lindenii (Bromeliaceae) and their frequency of visits across four reproductive events. We analyzed the frequency of the three groups of floral visitors (large bees, small bees, and hummingbirds) through focal observations in the reproductive events of 2015, 2016, 2017, and 2018. We evaluated the pollination efficacy (fecundity after one visit) through selective exposure treatments and the breeding system by manual pollinations. We tested if the reproductive success after natural pollination varied between the reproductive events and also calculated the pollen limitation index. E. lindenii is a self-incompatible and parthenocarpic species, requiring the action of pollinators for sexual reproduction. Hummingbirds had higher efficacy than large bees and small bees acted only as pollen larcenists. The relative frequency of the groups of floral visitors varied between the reproductive events. Pollen limitation has occurred only in the reproductive event of 2017, when visits by hummingbirds were scarce and reproductive success after natural pollination was the lowest. We conclude that hummingbirds and large bees were the main and the secondary pollinators of E. lindenii, respectively, and that temporal variations in the pollinator assemblages had effects on its reproductive success. Despite their lower pollination efficacy, large bees ensured seed set when hummingbirds failed. Thus, we provide evidence that variable pollination environments may favor generalization, even under differential effectiveness of pollinator groups if secondary pollinators provide reproductive assurance.

Educação ambiental no processo de territorialização em saúde: apresentação de um método utilizado / Environmental education in the process of territorialization in health: presentation of a method used

RESUMO O objetivo deste artigo foi apresentar um método qualitativo de abordagem da educação ambiental no processo de territorialização em saúde. O percurso metodológico que dá origem a este texto é uma pesquisa-ação cujo estudo é do tipo exploratório e descritivo de abordagem qualitativa por meio do desenvolvimento de oficinas. Foram realizados seis encontros para atender aos objetivos propostos. As atividades foram desenvolvidas por um moderador e contaram com a participação de 60 Agentes Comunitários de Saúde atuantes em um município de pequeno porte do interior e do litoral da Bahia. Os resultados apontam que, no processo de territorialização em saúde, é elementar a incorporação de novas práticas que demonstrem o território além de demarcações geográficas, valorizando a concepção ampliada de ambiente e suas relações com a saúde. Nesse ponto, surge como proposta a reorganização dos processos de trabalho, no sentido de buscar multidisciplinaridade, interdisciplinaridade e participação efetiva no processo de territorialização em saúde à luz da educação ambiental.

ABSTRACT This paper aims to present a method of qualitative approach to environmental education in the process of territorialization in health. The methodological path that gives rise to this text is an action-research whose study is exploratory and descriptive of qualitative approach through the development of workshops. Six meetings were held to meet the proposed objectives. The activities were developed by a moderator and were attended by 60 Community Health Workers working in a small municipality in both the countryside and the coast of Bahia. The results indicate that, in the process of territorialization in health, it is elementary to incorporate new practices that demonstrate the territory beyond geographical demarcations, valuing the broader conception of the environment and its relations with health. In that regard, the proposal that arises is the reorganization of work processes, in the sense of seeking multidisciplinarity, interdisciplinarity and effective participation in the process of territorialization in health, in light of environmental education.

Use of psychoactive substances among Brazilian adolescents and associated factors: National School-based Health Survey, 2015. / Uso de substâncias psicoativas em adolescentes brasileiros e fatores associados: Pesquisa Nacional de Saúde dos Escolares, 2015.

AIM: To analyze the consumption of tobacco, alcohol and illicit drugs among schoolchildren according to demographic factors, family context and mental health. METHODS: We used data from the National School-based Health Survey 2015 and included in the sample 102,301 schoolchildren in the 9th grade. We estimated the prevalence of tobacco and alcohol use in the last 30 days and drug experimentation according to demographic, mental health and family context variables. Then, a bivariate analysis was performed using Pearson's χ2 test and the unadjusted odds ratio (OR) was calculated. Finally, we conducted a multivariate analysis including independent variables with an unadjusted association (p < 0.20), for each outcome, estimating the adjusted OR with a 95% confidence interval. RESULTS: The prevalence of tobacco consumption was 5.6%; alcohol consumption, 23.8%; and drug experimentation, 9.0%. Multivariate analysis has indicated that living with parents, having meals with parents or guardian, and family supervision were associated with lower substance consumption; whereas missing classes without parental consent has increased the chances of substance use. Increased chance of substance use was also associated with white skin color, increasing age, to work, feeling lonely and having insomnia. Not having friends was associated with drug and tobacco use, but this was protective for alcohol consumption. CONCLUSIONS: Family supervision was protective for psychoactive substance use among Brazilian schoolchildren, whereas work, loneliness and insomnia have increased their chances of use.

OBJETIVO: Analisar o uso de substâncias psicoativas (tabaco, álcool e drogas ilícitas) em escolares em relação a fatores sociodemográficos, contexto familiar e saúde mental. MÉTODOS: Foram utilizados dados da amostra de 102.301 escolares do nono ano da Pesquisa Nacional de Saúde do Escolar de 2015. Realizou-se o cálculo da prevalência de uso de tabaco e de álcool nos últimos 30 dias e experimentação de drogas, segundo variáveis sociodemográficas, contexto familiar e saúde mental. Procedeu-se a análise univariada, por teste do χ2 de Pearson e cálculo das odds ratios (OR) não ajustadas. Por fim, realizou-se análise multivariada para cada desfecho com as variáveis que apresentaram associação com os desfechos (p < 0,20), calculando-se as OR ajustadas com intervalo de confiança de 95%. RESULTADOS: A prevalência de uso de tabaco foi de 5,6%; do uso de álcool, 23,8%; e da experimentação de drogas, 9,0%. A análise multivariada apontou que, no contexto familiar, morar com os pais, fazer refeição com pais ou responsável e a supervisão familiar foram associados a menor uso de substâncias; enquanto faltar às aulas sem consentimento dos pais aumentou a chance de uso. Maior chance do uso de substâncias esteve ainda associada a cor branca, aumento da idade, trabalhar, sentir-se solitário e ter insônia. Não ter amigos foi associado com uso de drogas e tabaco, porém foi protetor para o uso de álcool. CONCLUSÕES: A supervisão familiar foi protetora do uso de substâncias psicoativas em escolares brasileiros, enquanto trabalhar, sentir-se solitário e ter insônia aumentaram suas chances de uso.

Abordagem quanto ao diagnóstico e ao tratamento da avulsão dentária: uma revisão de literatura / Approach to diagnosis and treatment of dental avulsion: a literature review

Objetivo: descrever uma revisão da literatura que apresente as principais consequências que podem ocorrer quando o dente avulsionado é reimplantado de forma tardia, proporcionando um prognóstico desfavorável. Revisão de literatura: a avulsão dental é uma lesão traumática que se caracteriza pelo completo deslocamento do dente de seu alvéolo, acarretando danos tanto às estruturas de suporte do elemento dental quanto às estruturas pulpares. A permanência extraoral do elemento dental avulsionado por períodos longos ou em meios de armazenamento inadequados pode provocar danos adicionais. Considerações finais: as lesões de inserções são as principais consequências da pós-avulsão dentária, isso devido a uma ruptura do ligamento periodontal, com uma secagem excessiva antes do reimplante, danificando as células do ligamento periodontal, o que, por sua vez, provoca uma resposta inflamatória exacerbada em uma ampla área da superfície radicular. (AU)

Objective: to describe a literature review, which presents the main consequences of late reimplantation of the avulsed tooth, providing an unfavorable prognosis. Literature review: tooth avulsion is a traumatic lesion characterized by the complete displacement of the tooth from the socket, causing damage to the support structures of the dental element as well as to pulp structures. The long extraoral time of the avulsed tooth or the time in inadequate storage may cause additional trauma. Final considerations: insertion lesions are the main consequences of tooth post-avulsion due to a rupture in the periodontal ligament, with an excessive drying prior to reimplantation, which damages the periodontal ligament cells and causes an exacerbated inflammatory response in a large root surface area. (AU)

A importância da bioética na prática odontológica: considerações atuais da literatura / The importance of bioethics in the dental practice: current considerations from the literature

Objetivo: revisar a literatura sobre os meios pelos quais o cirurgião-dentista deve orientar sua conduta, tornando- se ciente daquilo que lhe é exigido em relação à sua profissão. Materiais e método: esta revisão de literatura foi conduzida pelos principais bancos de dados de saúde: PubMed, SciELO e Google Scholar. As palavras-chave para a busca textual foram: ética profissional (ethics, professional); educação em odontologia (education, dental); odontologia (dentistry). Os critérios de inclusão foram: literatura que aborde a temática em estudo, literatura dos últimos anos, idiomas inglês e português, estudos laboratoriais e clínicos e revisão sistemática. Os critérios de exclusão foram: revisão de literatura, carta ao editor, artigo de opinião, literatura duplicada em bases de dados e literatura que não abordasse as variáveis em estudo. Revisão de literatura: a bioética baseia-se em quatro princípios básicos que estabelecem uma metodologia para analisar os casos concretos e os problemas éticos que ocorrem na prática da assistência à saúde, sendo eles: não maleficência, beneficência, respeito à autonomia e justiça. Sendo esses princípios fundamentais para o desenvolvimento da bioética, com isso, abordando uma forma peculiar de definir e manejar os valores envolvidos nas relações dos profissionais de saúde e seus pacientes. Considerações finais: a bioética deve nortear os avanços dentro do respeito ao ser humano e à sua individualidade, sem que ocorram possíveis infrações. Todavia, são necessários maiores estudos para uma maior compreensão sobre o tema e as melhores medidas para cada caso em particular. (AU)

Objective: to review the literature on the means by which dentists should guide their behavior, becoming aware of the requirements concerning their profession. Materials and method: this literature review was performed by the main health databases of PubMed, Sci- ELO, and Google Scholar. The keywords for the text search were ethics, professional; education, dental; dentistry. The inclusion criteria were the literature addressing the subject studied, the recent literature, English and Portuguese languages, laboratory and clinical studies, and systematic reviews. The exclusion criteria were literature reviews, letters to the editor, opinion articles, the literature duplicated in databases, and the literature that did not address the variables studied. Literature review: bioethics is based on four basic principles that establish a methodology for analyzing the concrete cases and ethical problems occurring in the health care practice, as follows: non-maleficence, beneficence, respect for autonomy, and justice. These are fundamental principles for the development of bioethics, hence addressing a particular way of defining and managing the values involved in the relationships between health professionals and their patients. Final considerations: bioethics should guide the advances regarding human beings and their individuality, without the occurrence of potential infractions. However, further studies are required for a better understanding of the subject and for the best measures for each particular case. (AU)

Drug information center: challenges of the research process to answer enquiries in hospital pharmaceutical practices.

OBJECTIVE: To characterise information requests (IRs) from hospitals received by a drug information center (DIC-RS) according to the resolution of the inquiries. METHOD: The sample consisted of all requestors and their respective IRs registered in the DIC-RS database from January 2012 to December 2016. Request without information in the consulted literature (RWI) were categorised according to the institution of origin. IRs from hospitals were classified by the information source, topic and subtopic of the questions, and the number of drugs and the pharmacological or therapeutic group. RESULTS: A total of 2,500 IRs were analysed. Of those, 25% did not exhibit conclusive information in the consulted sources. RWI from hospitals represented 51% of all RWI, followed by those from community pharmacies (13%) and health centres (9%). Tertiary literature was the most commonly used source (73%) for IRs from hospitals. The greatest difficulties in finding information were related to off-label drug administration and indication issues (52% of RWI). The most common type of off-label use was related to changes in the original pharmaceutical form of the drug. Furthermore, 61% of RWI were directed at a specific drug, mostly systemic anti-infectives. CONCLUSION: We found that a quarter of the answers did not exhibit conclusive information in the consulted sources. Answers to IRs from the hospital environment exhibited the greatest extent of limited information, and off-label use was responsible for most cases.

Uso de substâncias psicoativas em adolescentes brasileiros e fatores associados: Pesquisa Nacional de Saúde dos Escolares, 2015 / Use of psychoactive substances among Brazilian adolescents and associated factors: National School-based Health Survey, 2015

RESUMO: Objetivo: Analisar o uso de substâncias psicoativas (tabaco, álcool e drogas ilícitas) em escolares em relação a fatores sociodemográficos, contexto familiar e saúde mental. Métodos: Foram utilizados dados da amostra de 102.301 escolares do nono ano da Pesquisa Nacional de Saúde do Escolar de 2015. Realizou-se o cálculo da prevalência de uso de tabaco e de álcool nos últimos 30 dias e experimentação de drogas, segundo variáveis sociodemográficas, contexto familiar e saúde mental. Procedeu-se a análise univariada, por teste do χ2 de Pearson e cálculo das odds ratios (OR) não ajustadas. Por fim, realizou-se análise multivariada para cada desfecho com as variáveis que apresentaram associação com os desfechos (p < 0,20), calculando-se as OR ajustadas com intervalo de confiança de 95%. Resultados: A prevalência de uso de tabaco foi de 5,6%; do uso de álcool, 23,8%; e da experimentação de drogas, 9,0%. A análise multivariada apontou que, no contexto familiar, morar com os pais, fazer refeição com pais ou responsável e a supervisão familiar foram associados a menor uso de substâncias; enquanto faltar às aulas sem consentimento dos pais aumentou a chance de uso. Maior chance do uso de substâncias esteve ainda associada a cor branca, aumento da idade, trabalhar, sentir-se solitário e ter insônia. Não ter amigos foi associado com uso de drogas e tabaco, porém foi protetor para o uso de álcool. Conclusões: A supervisão familiar foi protetora do uso de substâncias psicoativas em escolares brasileiros, enquanto trabalhar, sentir-se solitário e ter insônia aumentaram suas chances de uso.

ABSTRACT: Aim: To analyze the consumption of tobacco, alcohol and illicit drugs among schoolchildren according to demographic factors, family context and mental health. Methods: We used data from the National School-based Health Survey 2015 and included in the sample 102,301 schoolchildren in the 9th grade. We estimated the prevalence of tobacco and alcohol use in the last 30 days and drug experimentation according to demographic, mental health and family context variables. Then, a bivariate analysis was performed using Pearson's χ2 test and the unadjusted odds ratio (OR) was calculated. Finally, we conducted a multivariate analysis including independent variables with an unadjusted association (p < 0.20), for each outcome, estimating the adjusted OR with a 95% confidence interval. Results: The prevalence of tobacco consumption was 5.6%; alcohol consumption, 23.8%; and drug experimentation, 9.0%. Multivariate analysis has indicated that living with parents, having meals with parents or guardian, and family supervision were associated with lower substance consumption; whereas missing classes without parental consent has increased the chances of substance use. Increased chance of substance use was also associated with white skin color, increasing age, to work, feeling lonely and having insomnia. Not having friends was associated with drug and tobacco use, but this was protective for alcohol consumption. Conclusions: Family supervision was protective for psychoactive substance use among Brazilian schoolchildren, whereas work, loneliness and insomnia have increased their chances of use.

[Pre-pregnancy nutritional status, maternal weight gain, prenatal care, and adverse perinatal outcomes among adolescent mothers]. / Estado nutricional pré-gestacional, ganho de peso materno, condições da assistência pré-natal e desfechos perinatais adversos entre puérperas adolescentes.

OBJECTIVE: To identify the association between pre-gestational nutritional status, maternal weight gain, and prenatal care with low birth weight (LBW) and prematurity outcomes in infants of adolescent mothers. METHODS: Cross-sectional study with 542 pairs of adolescent mothers and their children attending a public maternity hospital in Rio de Janeiro. Data were collected from medical records. To determine the association between independent variables and the outcomes studied, odds ratio (OR) and a 95% confidence interval (CI) were estimated RESULTS: With respect to pre-pregnancy nutritional status of adolescents, 87% had normal weight, 1% were underweight, 10% were overweight, and 2% obese. Inadequate total gestational weight gain (72%) exceeded adequacy (28%). Birth weight was favored with greater gestational weight gain, and reduced with late onset of prenatal care. The comparison between the low birth weight and normal birth weight groups revealed significant differences between variable means: interval between the past pregnancy and current pregnancy (p = 0.022), pre-gestational weight (p = 0.018); pre-gestational body mass index (p < 0.001), and total gestational weight gain (p = 0.047). The odds of LBW (OR 2.70, 95% CI 1.45 to 5.06) and prematurity (OR 5.82, 95% CI 3.10 to 10.92) fell when the adolescent received six or more prenatal visits. CONCLUSION: Birth weight was associated with inter-gestational interval, pre-pregnancy weight and body mass index before pregnancy. The minimum frequency of six prenatal care visits was a protective factor against LBW and prematurity.

Estado nutricional pré-gestacional, ganho de peso materno, condições da assistência pré-natal e desfechos perinatais adversos entre puérperas adolescentes / Pre-pregnancy nutritional status, maternal weight gain, prenatal care, and adverse perinatal outcomes among adolescent mothers

OBJETIVO: Identificar associação entre estado nutricional pré-gestacional, ganho ponderal materno e condições do pré-natal com os desfechos prematuridade e baixo peso ao nascer (BPN) em filhos de mães adolescentes. MÉTODOS: Estudo transversal com 542 pares de puérperas adolescentes e conceptos atendidos em uma maternidade pública do município do Rio de Janeiro (RJ). Os dados foram coletados em prontuários. Para verificar a associação entre as variáveis independentes e os desfechos estudados, foram estimados a odds ratio (OR) e o intervalo de confiança (IC) de 95 por cento. RESULTADOS: Quanto ao estado nutricional pré-gestacional das adolescentes, 87 por cento apresentavam eutrofia, 1 por cento baixo peso, 10 por cento sobrepeso e 2 por cento obesidade. A inadequação do ganho de peso gestacional total (72 por cento) superou a adequação (28 por cento). O peso ao nascer foi favorecido com maior ganho de peso gestacional e reduzido com início tardio do pré-natal (PN). A comparação entre os grupos de conceptos com baixo peso e com peso adequado ao nascer revelou diferenças significativas entre as médias das variáveis: intervalo entre a última gestação e a atual (p = 0,022); peso pré-gestacional (p = 0,018); índice de massa corporal pré-gestacional (p < 0,001) e ganho de peso gestacional total (p = 0,047). As chances de BPN (OR 2,70; IC 95 por cento 1,45 - 5,06) e de prematuridade (OR 5,82; IC 95 por cento 3,10 - 10,92) reduziram quando a adolescente recebeu 6 ou mais consultas de PN. CONCLUSÃO: O peso ao nascer foi relacionado ao intervalo intergestacional, ao peso pré-gestacional e ao índice de massa corporal pré-gestacional. A frequência mínima de 6 consultas de assistência pré-natal constituiu-se em fator de proteção contra o BPN e a prematuridade.

OBJECTIVE: To identify the association between pre-gestational nutritional status, maternal weight gain, and prenatal care with low birth weight (LBW) and prematurity outcomes in infants of adolescent mothers. METHODS: Cross-sectional study with 542 pairs of adolescent mothers and their children attending a public maternity hospital in Rio de Janeiro. Data were collected from medical records. To determine the association between independent variables and the outcomes studied, odds ratio (OR) and a 95 percent confidence interval (CI) were estimated RESULTS: With respect to pre-pregnancy nutritional status of adolescents, 87 percent had normal weight, 1 percent were underweight, 10 percent were overweight, and 2 percent obese. Inadequate total gestational weight gain (72 percent) exceeded adequacy (28 percent). Birth weight was favored with greater gestational weight gain, and reduced with late onset of prenatal care. The comparison between the low birth weight and normal birth weight groups revealed significant differences between variable means: interval between the past pregnancy and current pregnancy (p = 0.022), pre-gestational weight (p = 0.018); pre-gestational body mass index (p < 0.001), and total gestational weight gain (p = 0.047). The odds of LBW (OR 2.70, 95 percent CI 1.45 to 5.06) and prematurity (OR 5.82, 95 percent CI 3.10 to 10.92) fell when the adolescent received six or more prenatal visits. CONCLUSION: Birth weight was associated with inter-gestational interval, pre-pregnancy weight and body mass index before pregnancy. The minimum frequency of six prenatal care visits was a protective factor against LBW and prematurity.

[Culture and health services: studying the participation of cultural traits of Brazilian society in the work process of primary healthcare services]. / Cultura e instituições de saúde: estudando a participação de traços culturais da sociedade brasileira no processo de trabalho de serviços de atenção básica.

The analysis of institutions is a widely researched area of health. The culture of organizations is understood as a symbolic possibility contained in a larger dimension, called "national culture". This premise justifies the incorporation of the social anthropological approach to the study of organizational culture. This study sought to establish the perceptions of employees of two primary healthcare services in Niterói, State of Rio de Janeiro, regarding commonly used social navigation strategies from the theory developed by Roberto DaMatta. The results showed the relational character associated with the stereotype of the Brazilian people manifested by conflicts arising from the existence of values based on the `individual' and the `person'. Among them are the distortions observed between discourse and practice, and the mobilization strategies of social navigation like "making do" - to establish a mediation between the person and the impersonal law. The organization of the services of the Niterói Family Medical Program apparently sets its employees the concrete challenge of balancing the egalitarian principle that underpins the Unified Health System (SSU) with the set of values upon which personal relations are based in Brazilian society.

Cultura e instituições de saúde: estudando a participação de traços culturais da sociedade brasileira no processo de trabalho de serviços de atenção básica / Culture and health serviçes: studying the participation of cultural traits of Brazilian society in the work process of primary healthcare services

A análise de instituições é assunto amplamente pesquisado na área da saúde. A cultura das organizações é entendida como uma possibilidade simbólica contida em uma dimensão maior, denominada "cultura nacional". Essa premissa justifica a incorporação da abordagem sócio antropológica aos estudos de cultura organizacional. O presente estudo propôs-se a conhecer as percepções de funcionários de dois serviços de atenção básica do município de Niterói/RJ sobre estratégias de navegação social comumente utilizadas a partir da teoria desenvolvida por Roberto DaMatta. Os resultados evidenciaram o caráter relacional associado ao estereótipo do brasileiro que se manifesta mediante conflitos decorrentes da coexistência de valores baseados no `indivíduo' e na `pessoa'. Entre eles destacam-se as distorções observadas entre discurso e prática e a mobilização de estratégias de navegação social como o "jeitinho" visando estabelecer uma mediação entre a lei impessoal e a pessoa. A forma de organização dos serviços do Programa Médico de Família de Niterói aparentemente impõe a seus funcionários o desafio concreto de equacionar o princípio igualitário que fundamenta o SUS com o conjunto de valores nos quais se baseiam as relações pessoais na sociedade brasileira.

The analysis of institutions is a widely researched area of health. The culture of organizations is understood as a symbolic possibility contained in a larger dimension, called "national culture". This premise justifies the incorporation of the social anthropological approach to the study of organizational culture. This study sought to establish the perceptions of employees of two primary healthcare services in Niterói, State of Rio de Janeiro, regarding commonly used social navigation strategies from the theory developed by Roberto DaMatta. The results showed the relational character associated with the stereotype of the Brazilian people manifested by conflicts arising from the existence of values based on the `individual' and the `person'. Among them are the distortions observed between discourse and practice, and the mobilization strategies of social navigation like "making do" - to establish a mediation between the person and the impersonal law. The organization of the services of the Niterói Family Medical Program apparently sets its employees the concrete challenge of balancing the egalitarian principle that underpins the Unified Health System (SSU) with the set of values upon which personal relations are based in Brazilian society.