RESUMEN
Mycosis fungoides (MF) is the most prevalent subtype of primary cutaneous T-cell lymphomas (CTCLs). Sézary syndrome (SS) is another entity defined by leukaemic involvement, lymphadenopathy and erythroderma. Pegylated liposomal doxorubicin (PEG-DOXO) is an anthracycline used in the management of advanced primary CTCL, particularly in induction strategies. However, there are limited data on its effectiveness and tolerability in real-life patients. We report 36 patients who received PEG-DOXO for MF or SS in our centre, describing the patients' characteristics, response rates and tolerance to the treatment. The best overall responses were observed for the skin, with lower response rates for nodal involvement and moderate responses for blood disease. The treatment was mainly well tolerated, without severe adverse events, and no cardiotoxicity was observed on cardiac function monitoring.
Asunto(s)
Linfoma Cutáneo de Células T , Micosis Fungoide , Síndrome de Sézary , Neoplasias Cutáneas , Doxorrubicina/efectos adversos , Doxorrubicina/análogos & derivados , Humanos , Linfoma Cutáneo de Células T/patología , Micosis Fungoide/tratamiento farmacológico , Micosis Fungoide/patología , Polietilenglicoles , Síndrome de Sézary/tratamiento farmacológico , Síndrome de Sézary/patología , Neoplasias Cutáneas/patologíaAsunto(s)
Acné Vulgar , Hiperostosis , Osteítis , Sinovitis , Acné Vulgar/diagnóstico , Acné Vulgar/tratamiento farmacológico , Humanos , SíndromeAsunto(s)
Enfermedad Relacionada con Inmunoglobulina G4/complicaciones , Enfermedad Relacionada con Inmunoglobulina G4/diagnóstico , Enfermedades Pulmonares/etiología , Enfermedades de las Glándulas Salivales/diagnóstico , Enfermedades de las Glándulas Salivales/etiología , Glándula Submandibular , Adulto , Humanos , Enfermedades Pulmonares/diagnóstico , MasculinoRESUMEN
The first vaccine that shows significant potential in providing broad coverage against serogroup B meningococcal disease has recently been approved. Because of its newness, potential adverse events need to be reported. Here we report a case of urticarial vasculitis, a rare disease in children, in probable relationship with the novel vaccine.
Asunto(s)
Infecciones Meningocócicas/prevención & control , Vacunas Meningococicas/efectos adversos , Neisseria meningitidis Serogrupo B/inmunología , Vasculitis Leucocitoclástica Cutánea/diagnóstico , Niño , Femenino , Antagonistas de los Receptores Histamínicos/uso terapéutico , Humanos , Piel/patología , Vasculitis Leucocitoclástica Cutánea/etiologíaRESUMEN
Tinea imbricata (TI) is a geographically restricted dermatophytosis with distinctive clinical and immunologic features. We present a case of TI occurring in a native Brazilian child with previously undiagnosed human immunodeficiency virus infection. Physicians should bear in mind that diagnosis of TI may be a clinical clue to potentially serious underlying immunodeficiency.
Asunto(s)
Infecciones por VIH/diagnóstico , Tiña/diagnóstico , Trichophyton/aislamiento & purificación , Administración Oral , Antifúngicos/uso terapéutico , Preescolar , Frente , Griseofulvina/uso terapéutico , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/microbiología , Humanos , Masculino , Tiña/tratamiento farmacológico , Tiña/microbiologíaRESUMEN
We report the first case of multisystemic Langerhans cell histiocytes mimicking diffuse neonatal hemangiomatosis clinically. This has been described in patients with congenital self-healing reticulohistiocytosis but not in patients with acute, disseminated, and multisystemic disease. In our experience, dermoscopic findings did not help to diagnose the condition.