Resistin and Plasma-reactive Oxygen Metabolite Levels in Obese and Non-obese Individuals with Chronic Periodontitis in Response to Non-surgical Periodontal Therapy.

AIM: To assess and compare the impact of non-surgical periodontal therapy on plasma reactive oxygen metabolites and resistin values in chronic periodontitis obese and non-obese patients. MATERIALS AND METHODS: Total 200 subjects were included in the present study and were broadly divided into two study groups with 100 patients in each group as follows: group A: Obese patients with chronic periodontitis, group B: Non-obese, normal weight patients with chronic periodontitis. Various following periodontal parameter were calculated at the baseline time and two months after the non-surgical periodontal therapy. Plasma reactive oxygen metabolite (RM) and serum and GCF resistin levelswere evaluated. Assessment of all the results was done by Statistical Package for Social Sciences (SPSS) software. RESULTS: Significant results were obtained while doing an inter-group comparison of clinical attachment levels between two study groups. Significant results were obtained while comparing the clinical attachment levels in both the study groups at different time intervals. Significant 9 reduction in the RM was seen in Group B subjects in comparison to Group A subjects 2 months after non-surgical periodontal therapy. CONCLUSION: In patients with chronic periodontitis, obesity can be considered as an important factor in the alteration of resistin levels. CLINICAL SIGNIFICANCE: Obese patients should be motivated for reducing weight so that periodontal therapy and other treatment modalities could be carried out more effectively.

Gutkha Addiction: Nicotine Dependence or a Conditioned Reflex?

BACKGROUND: A pre-packaged mixture of areca nut, tobacco, slaked lime, catechu, and flavoring agents is popularly known as Gutkha. Aim of study is to analyze the addiction biology of Gutkha chewing and to assess efficacy of a cessation program based on nicotine replacement therapy (NRT). MATERIALS AND METHODS: Patterns of addiction of 400 Gutkha chewers were analyzed with a questionnaire-based survey. Urine cotinine levels of 60 subjects undergoing NRT were periodically estimated using gas chromatography. RESULTS: Mean urine cotinine levels of relapse and relapse-free cases were 5800.38 µg/g of creatine and 5622.16 µg/g of creatine. The difference was not found to be statistically significant. A 83.3% of the subjects associated their chewing habit with day to day activities. Overall relapse rate was found to be 79%. The most common reported reason for relapse was unacceptable taste and form of nicotine chewing gums. CONCLUSION: Repetitive coexistence in time of an indifferent act and the act of chewing Gutkha where, the act of chewing is almost always preceded by the indifferent act sets in a conditioned reflex. Gutkha addiction can be considered as a form of conditioned reflex, rather than actual craving for nicotine.

Prevalence, treatment and recurrence of odontogenic keratocyst in central India.

OBJECTIVE: The present study aimed to evaluate the prevalence, sex predilection and treatment modalities of OKC in Central India. MATERIALS AND METHODS: Total 2900 patients were screened from various hospitals and centers. Age of patients and site of lesion was recorded. OKC was classified into initial, moderate and advanced depending on the radiological involvement and treatment modalities given with respect to the extent of the OKC. RESULT: Total 49 patients were diagnosed with the presence of OKC. It was found that mostly it is common in 3rd and 4th decades, with the mean age 28 years in males and 31 years in females. The most common site of occurrence was angle of mandible and the ramus region. The treatment of OKC, on the basis of the radiographic classification, gives excellent results with minimum recurrences. CONCLUSION: The most common age and site occurrence was relevant with that of previous studies (Browne, Br Dent J 128(5):225-231, 1970, Chen and Lin, Gaoxiong Yi Xue Ke Xue Za Zhi 2(9):601-607, 1986). This study concluded by considering multicentric incidence, prevalence of OKC in Central India, that the population should be screened for OKC. The screening should be done by clinical, radiological and histopathological. While screening all the parameters should be considered to diagnose and treat the patients for the prevention of morbidity.