Comparison Between Combination of Resonant Voice Therapy and Vocal Hygiene Education and Vocal Hygiene Education Only for Female Elementary School Teachers.

OBJECTIVE: The study compares the rehabilitation outcome of two voice intervention methods for female elementary school teachers with self-reported voice disorders. METHODS: A total of 34 female teachers from two primary schools volunteered in the study. Participants from one school were assigned to the experimental group (16 teachers), who received the combination of vocal hygiene education and resonant voice therapy. Participants from the other school were assigned to the control group (18 teachers), who received vocal hygiene education only. Pre- and post-treatment data were compared. RESULT: The total score of the Voice Handicap Index (VHI) decreased significantly from 12.19 ± 8.58 to 8.63 ± 7.27 (P < 0.05); the functional score of VHI significantly decreased from 5.38 ± 3.9 to 3.81 ± 3.62 (P < 0.05). No statistical significance was found in physiological and emotional scores of VHI. No statistical significance was found in the control group. In the experimental group, the maximum phonation time was increased from 14.34 ± 6.80s to 17.21 ± 6.06s (P < 0.05), Jitter decreased from 0.45% ± 0.13% to 0.26% ± 0.05% (P < 0.05), and Shimmer decreased from 0.21 ± 0.10. to 0.12 ± 0.03 (P < 0.05). Furthermore, the harmonic to noise ratio increased from 23.06 ± 2.99 to 25.23 ± 1.92 (P < 0.05), Spectrum Convergence Ratio increased from 0.53 ± 0.12 to 0.60 ± 0.11 (P < 0.05), yet no statistical significance was found in Nonlinear Energy Difference Ratio data for the experimental group. No statistical significance was found in the control group. In the auditory perception assessment (GRBAS), the G score decreased from 1.19 ± 0.54 to 0.81 ± 0.40 (P < 0.05), and the R score decreased from 1.19 ± 0.54 to 0.75 ± 0.45 (P < 0.05) in the experimental group. No statistical significance was found in the B, A, and S scores in the experimental group; moreover, none of the GRBAS scores in the control group demonstrated statistical significance. In the voice type component profile (VTC), the proportion of VTC1 of the experimental group increased significantly, while the proportions of VTC3 and VTC4 decreased significantly, indicating the improvement of voice quality was obvious after the intervention. The proportions of VTC of the control group did not demonstrate significant change. CONCLUSION: The results of this study show that a combination of vocal hygiene education and resonant voice therapy can significantly improve the voice function of professional voice users and effectively improve their voice quality. In this study, the professional voice users receiving vocal hygiene education only did not show significant improvement of their voice quality.

Evaluating the Voice Type Component Distributions of Excised Larynx Phonations at Three Subglottal Pressures.

Purpose The excised canine larynx provides an advantageous experimental framework in the study of voice physiology. In recent years, signal processing methods have been applied to analyze phonations in excised canine larynx experiments. However, phonations have a highly complex and nonstationary nature corresponding to different proportions of regular and chaotic signal elements. Current nonlinear dynamic methods that are used to assess the degree of irregularity in the voice fail to recognize the distribution of voice type components (VTCs). Method Based on measures of intrinsic dimension, this article presents a method to analyze the VTC distribution of phonations in excised canine larynx experiments. Thirty-nine phonation samples from 13 excised canine larynges at three different subglottal pressures were analyzed. Results Phonation produced with subglottal pressures above phonation instability pressure (PIP) and below phonation threshold pressure (PTP) resulted in high proportions of Voice Types 3 and 4, characterized by chaotic and noisy signals. Phonation produced with pressure between PTP and PIP contained mostly Type 1 voice, characterized by a regular and nearly periodic signal. Mean proportions of all VTCs varied significantly in comparisons of phonations produced with Sub-PTP and PTP as well as in comparisons of phonations produced with PTP and PIP. Conclusions Across all VTCs, the VTC profiles of normal and abnormal phonation differ significantly. Normal phonation is strongly associated with VTC1 (Voice Type Component 1), whereas abnormal phonation exhibits increased VTC4 (Voice Type Component 4). The study further demonstrates the ability of intrinsic dimension to successfully detect multiple voice types in an acoustic signal and highlights the need for expanded use of intrinsic dimension in human voice. Supplemental Material https://doi.org/10.23641/asha.14417585.

A multipurpose brachytherapy catheter to enable intratumoral injection.

PURPOSE: To create and test a multipurpose brachytherapy catheter prototype enabling intratumoral injection and brachytherapy after a single catheter insertion. METHODS AND MATERIALS: The design of the prototype consists of an outer tube and an inner syringe tube that can be filled with injectable agent. The outer sheath and inner syringe tube were constructed using polytetrafluoroethylene tubing, and the other components were 3D printed using dental resin and polylactic acid material. To demonstrate functionality, we injected in vitro phantoms with dyed saline. For proof of concept, we demonstrated the potential for the prototype to deliver cell therapy, enhance tumor delineation, deliver tattoo ink for pathology marking, avoid toxicity through local delivery of chemotherapy, and facilitate combination brachytherapy and immunotherapy. RESULTS: The prototype enables accurate injection in vitro and in vivo without altering dosimetry. To illustrate the potential for delivery of cell therapies, we injected luciferase-expressing splenocytes and confirmed their delivery with bioluminescence imaging. To demonstrate feasibility of radiographically visualizing injected material, we delivered iohexol contrast intratumorally and confirmed tumor retention using Faxitron x-ray imaging. In addition, we show the potential of intratumoral administration to reduce toxicity associated with cyclophosphamide compared with systemic administration. To demonstrate feasibility, we treated tumor-bearing mice with brachytherapy (192Ir source, 2 Gy to 5 mm) in combination with intratumoral injection of 375,000 U of interleukin 2 and observed no increased toxicity. CONCLUSIONS: These results demonstrate that a prototype multipurpose brachytherapy catheter enables accurate intratumoral injection and support the feasibility of combining intratumoral injection with brachytherapy.

Effects of Varying Lengths and Diameters During Straw Phonation on an Excised Canine Model.

OBJECTIVE/BACKGROUND: Straw phonation, a well-established method of vocal exercise, started over 100 years ago. However, some of the most basic questions about best practices remain including the ideal extension length and the ideal restriction (semiocclusion) diameter. This study aims to help answer these questions by looking at both separately, with all other variables controlled. METHODS: Four (4) straws with lengths of 5, 25, 50, and 75 centimeters and 4 restrictions with diameters of 3, 9, 15, and 21 mm were tested, separately. They were attached to the end of a simulated vocal tract which was then affixed to an excised canine larynx. Airflow was increased until the larynges achieved self-sustained phonation then aerodynamic, acoustic, and electroglottographic data were collected. RESULTS: There was a significant decrease in the phonation threshold pressure using the 5 and 25 cm straw lengths and the 9 and 15 mm restrictions. The phonation threshold flow and contact quotient saw insignificant changes, except in the case of the 3 mm restriction. DISCUSSION: It is theorized that the increased inertive reactance helps to decrease phonation threshold pressure. By controlling for all other variables, the effects of the length or diameter of the straw can be analyzed in isolation. These results narrow the significant range of lengths and diameters used in straw phonation.

Quantification of Voice Type Components Present in Human Phonation Using a Modified Diffusive Chaos Technique.

PURPOSE: Signal typing has been used to categorize healthy and disordered voices; however, human voices are likely comprised of differing proportions of periodic type 1 elements, type 2 elements that are periodic with modulations, aperiodic type 3 elements, and stochastic type 4 elements. A novel diffusive chaos method is presented to detect the distribution of voice types within a signal with the goal of providing an objective and clinically useful tool for evaluating the voice. It was predicted that continuous calculation of the diffusive chaos parameter throughout the voice sample would allow for construction of comprehensive voice type component profiles (VTCP). METHODS: One hundred thirty-five voice samples of sustained /a/ vowels were randomly selected from the Disordered Voice Database Model 4337. All samples were classified according to the voice type paradigm using spectrogram analysis, yielding 34 type 1, 35 type 2, 42 type 3, and 24 type 4 voice samples. All samples were then analyzed using the diffusive chaos method, and VTCPs were generated to show the distribution of the 4 voice type components (VTC). RESULTS: The proportions of VTC1 varied significantly between the majority of the traditional voice types (P < .001). Three of the 4 VTCs of type 3 voices were significantly different from the VTCs of type 4 voices (P < .001). These results were compared to calculations of spectrum convergence ratio, which did not vary significantly between voice types 1 and 2 or 2 and 3. CONCLUSION: The diffusive chaos method demonstrates proficiency in generating comprehensive VTCPs for disordered voices with varying severity. In contrast to acoustic parameters that provide a single measure of disorder, VTCPs can be used to detect subtler changes by observing variations in each VTC over time. This method also provides the advantage of quantifying stochastic noise components that are due to breathiness in the voice.