Anthropological measurements of the skeleton and parathyroid glands growth during fetal development.

The article presents the investigation of histomorphological differentiation and growth of parathyroid glands in human fetus from the second to the ninth lunar month. The longer and the shorter diameter of these glands were measured. The obtained values are compared with the development and the growth intensity of the skeleton (biparietal head diameter and femoral length of a fetus from lunar months 3 to 9) and with the role of the placenta in the mentioned processes. The results of our investigation show the concordance of the skeletal growth with the development and histomorphological differentiation of these glands. The factors involved in these processes point out the complex relationship between the mother and fetus during osteogenesis, expressed on the hormonal level, in mineral metabolism and placental activity.

[The usefulness of the chorionic villi technic in prenatal diagnosis]. / Korisnost korion frondozum tehnike u prenatalnoj dijagnozi.

The chorion frondosum technique was performed, after a pilot study, in 33 early pregnancies (1986-1988). The procedure was carried out between the 8th and the 12th week of pregnancy, and the indications were the gravida's age, chromosomal abnormality in parents and in the child previously born in the family, and sex-linked disease. Out of 33 cultures examined after transcervical CF biopsy, 11 were confirmed also by the findings of early amniocentesis. The method of Siloni et al. was applied to chorion frondosum cells, both by direct and indirect cultivation: 28 of the total of 33 cultures were successful, while 5 failed. Three fetuses, one with balanced translocation and two normal ones, were spontaneously aborted in the first two weeks following the procedure. Three fetuses were aborted due to medical indication, two translocation forms of DS with the mother carrier of t 21/21 and one translocation form of Sy. Patau with the mother having mixoploidy 46; XX/45,XX,t(13q;13q). So far nine children of the predicted kariotype and sex have been born and their development is normal. The course of the remaining pregnancies is also normal, except for one with the spontaneous abortion in the 24th week.