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1.
Rehabilitation (Stuttg) ; 56(1): 47-54, 2017 Feb.
Artículo en Alemán | MEDLINE | ID: mdl-28219100

RESUMEN

To ascertain the current development of the rehabilitation-related medical teaching in the interdisciplinary subject Rehabilitation, Physical Medicine, Naturopathic Treatment (Q12) regarding its execution, content, exams and evaluation of teaching at the Medical Faculties the German Society of Rehabilitation Science conducted another faculty survey in 2015. Representatives of all degree courses of human medicine in German Universities (n=41) received a pseudonymised standardised questionnaire in summer 2015. The response rate was 76% (n=31). Half of the faculties (48%) stated that they had a teaching and research unit for at least 1 of the 3 subjects of the interdisciplinary Q12. The Q12-teaching of faculties including these units partially differed from the other faculties. Model medical education programmes provide on average 2 semesters more for Q12-teaching in comparison to the traditional programmes. More than 3 quarters of the traditional programmes and all other courses include other medical professionals besides physicians as lecturers. Multiple choice questions still constitute the most common examination type (94%). Nearly all Medical Faculties evaluate the rehabilitation-related teaching but only half of all them have implemented a financial gratification based on the evaluation results. Even 10 years after the implementation of Q12, major variations were demonstrated regarding the execution, content and methods of medical education in rehabilitation. In the future the influence of the National Competence Based Catalogues of Learning Objectives for Undergraduate Medical Education on the Q12-development and the Q12-teaching in medical university education in Germany with foreign qualification will be of particular interest.


Asunto(s)
Terapias Complementarias/educación , Curriculum/estadística & datos numéricos , Educación Médica/estadística & datos numéricos , Docentes/estadística & datos numéricos , Medicina Física y Rehabilitación/educación , Rehabilitación/educación , Centros Médicos Académicos/estadística & datos numéricos , Actitud del Personal de Salud , Evaluación Educacional , Alemania , Naturopatía , Grupo de Atención al Paciente/estadística & datos numéricos , Encuestas y Cuestionarios , Enseñanza/estadística & datos numéricos
2.
Unfallchirurg ; 113(6): 462-8, 2010 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-20552323

RESUMEN

The number of elderly and old patients with fractures is steadily increasing. Identification of relevant functional deficits and comorbidities is crucial for an efficient treatment strategy and outcome assessment in this patient group. For this reason the integration of a geriatric assessment in every orthopedic traumatology practice seems recommendable. Assessing the outcome of frequent fragility fractures (hip, radius) requires instruments oriented to the International Classification of Functioning, Disability and Health (ICF) which allow analysis of bodily function and structure as well as activity and participation. A combination of disease and body region-specific scores with generic scores seems to be reasonable. It can also be sensible to include instruments for health economic analyses.


Asunto(s)
Evaluación de la Discapacidad , Evaluación Geriátrica/métodos , Clasificación Internacional de Enfermedades , Evaluación de Resultado en la Atención de Salud/métodos , Calidad de Vida , Recuperación de la Función , Heridas y Lesiones/diagnóstico , Heridas y Lesiones/terapia , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Organización Mundial de la Salud , Heridas y Lesiones/clasificación
3.
Unfallchirurg ; 113(6): 448-55, 2010 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-20502853

RESUMEN

Multiple trauma and injuries are the main causes for mortality and long term disability in the younger population under 50 years old. Monitoring patient-relevant long term consequences after an acute event is therefore of high importance. However, there is no systematic overview on the assessment instruments and their concepts used to monitor long term outcome of multiple trauma. The International Classification of Functioning, Disability and Health (ICF) is a framework to standardize and compare assessment instruments. We conducted a systematic search of the electronic databases Medline and Embase covering the years 2000 to 2006 and data on utilized instruments were extracted from the retrieved studies. The corresponding concepts were identified and coded using the ICF. A total of 117 studies with 112 instruments were included and 1,032 different concepts were extracted of which 93% could be coded. This review confirms the heterogeneity and complexity of the problems encountered after multiple trauma. A homogeneous concept for assessment of long term outcome is warranted.


Asunto(s)
Evaluación de la Discapacidad , Indicadores de Salud , Evaluación de Resultado en la Atención de Salud/métodos , Calidad de Vida , Recuperación de la Función , Heridas y Lesiones/clasificación , Heridas y Lesiones/diagnóstico , Humanos , Clasificación Internacional de Enfermedades
4.
Unfallchirurg ; 113(6): 441-7, 2010 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-20502854

RESUMEN

The International Classification of Functioning, Disability and Health (ICF) provides a comprehensive and structured treatment management and outcome evaluation in trauma care based on specific ICF core sets and the ICF-based Rehab-CYCLE. The Rehab-CYCLE allows the problem-based assessment of functioning in a multi-professional team under physician-guidance and the definition of long-term, intervention and cycle goals. Defined intervention goals are assigned to the appropriate intervention principles and techniques as well as the specific evaluation instruments. Together with the patient additional intervention goals are identified, intervention principals adapted and the further treatment setting planned based on a multi-professional outcome evaluation. The standardized documentation is reported multi-professionally on the ICF assessment sheet which reflects the patient perspective with all their problems and needs as well as the perspective of the treatment team.


Asunto(s)
Evaluación de la Discapacidad , Clasificación Internacional de Enfermedades , Evaluación de Resultado en la Atención de Salud/métodos , Calidad de Vida , Recuperación de la Función , Heridas y Lesiones/diagnóstico , Heridas y Lesiones/terapia , Humanos , Organización Mundial de la Salud , Heridas y Lesiones/clasificación
5.
Unfallchirurg ; 113(6): 436-40, 2010 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-20505922

RESUMEN

The WHO International Classification of Functioning, Disability and Health (ICF) allows a standardized description of functioning and disability based on individual and contextual factors. The ICF adopts a biopsychosocial model of disability and functioning and is complementary to the ICD-10 (International Classification of Diseases). For its implementation in clinical practice ICF-based instruments, such as the ICF core sets were developed in a standardized scientific process. These consist of the ICF categories which are most relevant for patients with specific diseases or in specific health care situations. In trauma care the ICF and ICF core sets can be applied in defined health problems and treatment situations for documentation of functioning, structured planning and implementation of interventions as well as outcome assessment.


Asunto(s)
Evaluación de la Discapacidad , Clasificación Internacional de Enfermedades , Evaluación de Resultado en la Atención de Salud/métodos , Calidad de Vida , Recuperación de la Función , Heridas y Lesiones/clasificación , Heridas y Lesiones/diagnóstico , Humanos , Organización Mundial de la Salud
8.
Z Rheumatol ; 67(7): 565-74, 2008 Nov.
Artículo en Alemán | MEDLINE | ID: mdl-18825392

RESUMEN

The International Classification of Functioning, Disability, and Health (ICF) created by the World Health Organization provides both a framework and a classification comprehensively covering domains of function and disability in rheumatologic patients. The ICF can be used as a universal language understood by medical doctors, health professionals, researchers, patients, and other groups. It is based on an integrative biopsychosocial model of functioning. For its implementation in rheumatology and medicine in general, practical ICF-based tools such as the ICF Core Sets are necessary. These Sets, which were developed in a standardized scientific process, consist of the ICF categories that are most relevant for a specific group of patients, e.g. chronic patients with rheumatoid arthritis. In rheumatologic rehabilitation, patient problems, medical findings, treatment goals, and treatment concepts can be structured by applying the ICF, ICF Core Sets, and an ICF assessment sheet to patients. In outcomes research, ICF Core Sets can support the selection of relevant outcome domains.


Asunto(s)
Evaluación de la Discapacidad , Clasificación Internacional de Enfermedades , Evaluación de Resultado en la Atención de Salud/métodos , Garantía de la Calidad de Atención de Salud/métodos , Enfermedades Reumáticas/diagnóstico , Enfermedades Reumáticas/rehabilitación , Femenino , Alemania , Humanos , Masculino , Enfermedades Reumáticas/clasificación , Resultado del Tratamiento
9.
Clin Rheumatol ; 27(11): 1355-61, 2008 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-18521651

RESUMEN

The objective of the study was to identify commonalities among the International Classification of Functioning, Disability and Health (ICF) Core Sets of osteoarthritis (OA), osteoporosis (OP), low back pain (LBP), rheumatoid arthritis (RA) and chronic widespread pain (CWP). The aim is to identify relevant categories for the development of a tentative ICF Core Set for musculoskeletal and pain conditions. The ICF categories common to the five musculoskeletal and pain conditions in the Brief and Comprehensive ICF Core Sets were identified in three steps. In a first step, the commonalities across the Brief and Comprehensive ICF Core Sets for these conditions were examined. In a second and third step, we analysed the increase in commonalities when iteratively excluding one or two of the five conditions. In the first step, 29 common categories out of the total number of 120 categories were identified across the Comprehensive ICF Core Sets of all musculoskeletal and pain conditions, primarily in the component activities and participation. In the second and third step, we found that the exclusion of CWP across the Comprehensive ICF Core Sets increased the commonalities of the remaining four musculoskeletal conditions in a maximum of ten additional categories. The Brief ICF Core Sets of all musculoskeletal and pain conditions contain four common categories out of a total number of 62 categories. The iterative exclusion of a singular condition did not significantly increase the commonalities in the remaining. Based on our analysis, it seems possible to develop a tentative Comprehensive ICF Core Set across a number of musculoskeletal conditions including LBP, OA, OP and RA. However, the profile of functioning in people with CWP differs considerably and should not be further considered for a common ICF Core Set.


Asunto(s)
Evaluación de la Discapacidad , Dimensión del Dolor , Índice de Severidad de la Enfermedad , Encuestas y Cuestionarios , Artritis Reumatoide/diagnóstico , Humanos , Dolor de la Región Lumbar , Osteoartritis/diagnóstico , Osteoporosis/diagnóstico
10.
Rehabilitation (Stuttg) ; 47(1): 2-7, 2008 Feb.
Artículo en Alemán | MEDLINE | ID: mdl-18247265

RESUMEN

BACKGROUND: Rehabilitation, Physical Medicine, Naturopathic Treatment (Querschnittsbereich Q-12) was introduced as a compulsory interdisciplinary subject in the revised Federal Medical Licensing Regulations (Approbationsordnung für Arzte) in October 2003. This offered the opportunity to increase the students' interest in rehabilitation-related issues and to integrate current evidence of rehabilitation research. The implementation of the Q-12 in the German medical faculties was investigated by yearly questionnaires during a three-year-period. METHODS: In 2004, 2005, and 2006/07 anonymous postal questionnaires concerning the teaching in Q-12 were sent to the 36 medical faculties in Germany. Non-responders were reminded at least once by a repeat postal questionnaire. RESULTS: The response rates were 67% in 2004, 72% in 2005, 50% in 2006/07, respectively. Of the 36 faculties 34 responded at least once. Ten faculties responded to all questionnaires. In a considerable number of faculties, Q-12 is being coordinated by university institutions which are not denominated as one of the subjects designated in the Q-12 title. Major differences regarding the implementation of Q-12 were found between the faculties. Further development of Q-12 faces several limitations of resources. Almost all faculties provide curricula for teaching Q 12, some of which are still incomplete. During all three examinations lecturer-centered teaching methods (lectures, seminars, other presentations) were used most frequently. POL-cases and other structured patient oriented teaching were also reported less frequently. E-learning was very rarely offered to the students. Musculoskeletal and neurological disorders were the most frequent specific indications for practice-related integration of Q-12 issues. Compulsory election subjects (Wahlpflichtfächer) related to Q-12 issues before and during the final year of the medical students, are not being offered by all faculties. The vast majority of the faculties advocate an exchange of materials for teaching and examinations. CONCLUSIONS: During the three examinations, major differences concerning the implementation of Q-12 were found between the faculties. Therefore, it is recommended that all faculties verify whether they adequately cover the joint educational objectives recommended for Q-12 by two German scientific societies. Furthermore, the more frequent application of up-to-date practice-oriented teaching and examination methods, an intensified implementation of Q-12-related issues in teaching specific indications, the completion of curricula, enhanced offer of compulsory election subjects related to Q-12 issues, continued scientific investigations and symposia/workshops concerning the promotion of Q-12-related teaching as well as the generation and exchange of teaching and examination materials are recommended.


Asunto(s)
Curriculum/tendencias , Naturopatía , Grupo de Atención al Paciente , Medicina Física y Rehabilitación , Rehabilitación/educación , Facultades de Medicina/tendencias , Enseñanza/tendencias , Alemania
11.
Rehabilitation (Stuttg) ; 46(3): 164-74, 2007 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-17582557

RESUMEN

Through innovative teaching and learning methods relevant topics in rehabilitation can be conveyed effectively. Therefore, in this paper a papercase for problem-oriented learning (POL) is presented concerning rehabilitation in rheumatology, exemplified by a patient with ankylosing spondylitis. This papercase can be applied in the integrated course Rehabilitation, Physical Medicine and Naturopathic Treatment, the curricular part of teaching rehabilitation during the medical training according to the 9 (th) revision of the Federal Medical Licensing Regulations (Approbationsordnung). In addition the teaching material presented can be used in other courses, such as elective courses for non-medical professionals of the interdisciplinary rehabilitation team. First experiences gathered with the papercase in the Health and Nursing Sciences study programme of the Faculty of Medicine of Martin-Luther-University Halle-Wittenberg are reported.


Asunto(s)
Aprendizaje Basado en Problemas , Rehabilitación/educación , Espondilitis Anquilosante/rehabilitación , Curriculum , Educación Médica , Alemania , Objetivos , Humanos , Grupo de Atención al Paciente , Proyectos Piloto , Enfermería en Rehabilitación/educación , Espondilitis Anquilosante/diagnóstico
12.
Rehabilitation (Stuttg) ; 46(2): 64-73, 2007 Apr.
Artículo en Alemán | MEDLINE | ID: mdl-17464901

RESUMEN

With introduction of the new Federal Medical Licensing Regulations (Approbationsordnung) in Germany, integrated teaching in "Rehabilitation, Physical Medicine, Naturopathic Treatment" (Querschnittsbereich Q12) has become obligatory for the first time. Furthermore, the new Regulations require the medical faculties in Germany to realize an innovative didactic orientation in teaching. This paper provides an overview of recent applications of teaching techniques and examination methods in medical education with special consideration of the new integrated course Q12 and further teaching methods related to rehabilitative issues. Problem-oriented learning (POL), problem-based learning (PBL), bedside teaching, eLearning, and the examination methods Objective Structured Clinical Examination (OSCE) and Triple Jump are in the focus. This overview is intended as the basis for subsequent publications of the Commission for Undergraduate and Postgraduate Training of the German Society of Rehabilitation Science (DGRW), which will present examples of innovative teaching material.


Asunto(s)
Educación Médica/legislación & jurisprudencia , Licencia Médica/legislación & jurisprudencia , Rehabilitación/educación , Enseñanza/métodos , Competencia Clínica/legislación & jurisprudencia , Instrucción por Computador , Curriculum/normas , Educación de Postgrado en Medicina/legislación & jurisprudencia , Evaluación Educacional/métodos , Docentes Médicos/normas , Alemania , Humanos , Aprendizaje Basado en Problemas
13.
Radiologe ; 46(6): 520-6, 2006 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-16786389

RESUMEN

More than 80% of vertebrogenic lumbar pain is unspecific and can only be attributed to a specific anatomic structure with difficulty. The pain can emanate from the intervertebral discs, intervertebral and sacroiliac (SI) joints, musculature, and ligaments. In a maximum of 7% of cases, the pain is radicular (4% due to intervertebral discs and 3% caused by stenoses). In 7-15% of cases, the pain's origin is located in the region of the vertebral joints and in up to 15% in the region of the SI joint. Although the overwhelming majority of pain has no clear structural cause, infiltrations of medications and nerve blockades are frequently employed. The efficacy of these procedures has however not been verified in controlled studies with the exception of epidural injection of corticosteroids for radicular pain. Epidural and epiradicular application of corticosteroids appear to be effective for radicular pain, at least on a short-term basis, although controlled studies have yielded controversial results. The difficulty lies partly in the exact placement at the affected root for applying the medication. This is hardly possible with a caudal injection, while with a lumbar peridural injection and periradicular injections it is only possible under X-ray control or even better CT guidance.


Asunto(s)
Corticoesteroides/uso terapéutico , Dolor de Espalda/terapia , Desplazamiento del Disco Intervertebral/tratamiento farmacológico , Artropatías/terapia , Dolor de la Región Lumbar/terapia , Bloqueo Nervioso/métodos , Enfermedades de la Columna Vertebral/terapia , Dolor de Espalda/etiología , Humanos , Inyecciones Epidurales , Desplazamiento del Disco Intervertebral/complicaciones , Artropatías/complicaciones , Dolor de la Región Lumbar/epidemiología , Guías de Práctica Clínica como Asunto , Pautas de la Práctica en Medicina , Radiculopatía/complicaciones , Radiculopatía/terapia , Medición de Riesgo/métodos , Factores de Riesgo , Enfermedades de la Columna Vertebral/complicaciones , Resultado del Tratamiento
14.
Rehabilitation (Stuttg) ; 43(6): 337-47, 2004 Dec.
Artículo en Alemán | MEDLINE | ID: mdl-15565535

RESUMEN

In October 2003 the 9 (th) revision of the Federal Medical Training Regulations (Approbationsordnung) came into effect. The new compulsory interdisciplinary subject "Rehabilitation, Physical Medicine, Naturopathic Treatment" offers the opportunity to teach all students in comprehensive concepts of Rehabilitation such as the International Classification of Functioning, Disability and Health (ICF) of the WHO and the new book 9 of the German Social Code (SGB 9), as well as Physical Medicine and Naturopathic Treatment. Since the content of this new subject has not been defined up to date a joint task force of the German Society of Rehabilitation Science and the German Society of Physical Medicine and Rehabilitation was founded in order to recommend teaching standards. As part of these teaching standards educational objectives are introduced in this article. They should guide the persons in charge of teaching the subject in the medical faculties. In some areas the students should acquire profound abilities and skills in addition to knowledge. The medical faculties may focus on different educational targets according to their individual teaching profile.


Asunto(s)
Curriculum , Educación Médica/legislación & jurisprudencia , Educación Médica/normas , Licencia Médica/legislación & jurisprudencia , Licencia Médica/normas , Naturopatía , Medicina Física y Rehabilitación/educación , Rehabilitación/educación , Terapias Complementarias/educación , Terapias Complementarias/legislación & jurisprudencia , Alemania , Guías como Asunto , Medicina Física y Rehabilitación/legislación & jurisprudencia , Medicina Física y Rehabilitación/normas , Competencia Profesional/legislación & jurisprudencia , Competencia Profesional/normas , Rehabilitación/legislación & jurisprudencia , Rehabilitación/normas , Investigación/educación , Investigación/legislación & jurisprudencia , Proyectos de Investigación
16.
Orthopade ; 32(10): 865-8, 2003 Oct.
Artículo en Alemán | MEDLINE | ID: mdl-14579018

RESUMEN

Spinal stenosis mainly is a disease of the elderly. In most cases the lumbar spine is affected. The assessment is based on the typical constellation of symptoms (neurogenic claudication, subjective weakness) and physical findings (abnormal reflex status, loss of strength, sensory deficits, impairment in balance and coordination). The diagnosis is further supported by the radiologic proof of a stenosis of the spinal canal, the lateral recess, and the intervertebral foramina. The main targets of physical and rehabilitative medicine are the relief of pain and an improvement in the activities of daily living, which are especially impaired by reduced walking distance and difficulties in climbing stairs. These can be achieved by multimodal, conservative management: physiotherapy, occupational therapy, treatment of myofascial disorders, and oral medication/local injections. Physiotherapy aims at a stabilization of the lumbar spine in a flexed posture rather than in lumbar lordosis and at an increase of overall physical fitness. Oral analgetic and/or anti-inflammatory medical management is based on the three-step scheme of the World Health Organization, which also can be applied for low back pain. Local injections can help to control symptoms. Myofascial disorders are treated by techniques and procedures such as traditional massage.


Asunto(s)
Dolor de la Región Lumbar/rehabilitación , Síndromes del Dolor Miofascial/rehabilitación , Cuidados Paliativos/métodos , Modalidades de Fisioterapia/métodos , Estenosis Espinal/rehabilitación , Actividades Cotidianas , Analgésicos/uso terapéutico , Terapia Combinada/métodos , Humanos , Masaje , Síndromes del Dolor Miofascial/etiología , Pautas de la Práctica en Medicina , Recuperación de la Función , Estenosis Espinal/complicaciones , Estenosis Espinal/terapia , Resultado del Tratamiento
17.
Ther Umsch ; 58(8): 493-6, 2001 Aug.
Artículo en Alemán | MEDLINE | ID: mdl-11552356

RESUMEN

Spinal stenosis mainly is a disease of the elderly patient. Mostly the lumbar spine is affected. The assessment is based on the typical constellation of symptoms (neurogenic claudication, subjective weakness) and physical findings (abnormal reflex status, loss of strength, sensory deficits). It further is supported by the radiographic proof of stenosis of the spinal canal, the lateral recess and the intervertebral foramina. The targets of physical therapy are the relief of pain and an improvement concerning the activities of daily living, which are especially impaired by reduced walking distance and difficulties in climbing stairs as well. That can be achieved by physiotherapy treatment of myofascial disorders oral medication/local injection.


Asunto(s)
Modalidades de Fisioterapia/métodos , Estenosis Espinal/terapia , Factores de Edad , Antiinflamatorios no Esteroideos/uso terapéutico , Descompresión Quirúrgica , Diagnóstico Diferencial , Humanos , Incidencia , Región Lumbosacra , Polirradiculopatía/cirugía , Estenosis Espinal/diagnóstico , Estenosis Espinal/epidemiología , Estados Unidos/epidemiología
18.
Psychiatr Q ; 72(1): 63-77, 2001.
Artículo en Inglés | MEDLINE | ID: mdl-11293202

RESUMEN

Jails and prisons have become a final destination for persons with severe mental illness in America. Addiction, homelessness, and fragmentation of services have contributed to the problem, and have underscored the need for new models of service delivery. Project Link is a university-led consortium of five community agencies in Monroe County, New York that spans healthcare, social service and criminal justice systems. The program features a mobile treatment team with a forensic psychiatrist, a dual diagnosis treatment residence, and culturally competent staff. This paper discusses the importance of service integration in preventing jail and hospital recidivism, and describes steps that Project Link has taken towards integrating healthcare, criminal justice, and social services. Results from a preliminary evaluation suggest that Project Link may be effective in reducing recidivism and in improving community adjustment among severely mentally ill patients with histories of arrest and incarceration.


Asunto(s)
Prestación Integrada de Atención de Salud , Trastornos Mentales , Servicios de Salud Mental/organización & administración , Servicios Preventivos de Salud/organización & administración , Prisioneros/psicología , Prisioneros/estadística & datos numéricos , Prisiones , Adulto , Femenino , Humanos , Masculino , Trastornos Mentales/prevención & control , Trastornos Mentales/psicología , Trastornos Mentales/rehabilitación , Servicios de Salud Mental/tendencias , Modelos Organizacionales , Evaluación de Programas y Proyectos de Salud , Estados Unidos
19.
Int J Mol Med ; 5(3): 247-51, 2000 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-10677564

RESUMEN

The modification of ferritin in human skin cells in vitro and in vivo following infrared-A irradiation by immunohistochemical analysis and ELISA were evaluated. In addition, we observed that IR-A is not capable of inducing frank damage to DNA (pyrimidine dimers, p53), induction of oxidative stress proteins (heme oxygenase, nitric oxide, superoxide dismutase, heat shock proteins) or proteases (collagenase, stromelysin, gelatinase) involved in carcinogenesis and photoaging of the skin. in vivo, basal levels of ferritin were heterogeneous for all individuals tested but all showed ferritin to stain precisely in the basal layer of unirradiated epidermis. Following IR-A radiation, the ferritin increase was localized to epidermal tissue and showed an increase from 120 to 220%. Parallel to the in vivo analysis, dermal fibroblasts were cultured from six individuals. Quantitative analysis for ferritin in cultured fibroblasts was assessed by ELISA and increases were seen to be dose-dependent and up to 130% of basal levels of ferritin following infrared-A. Our findings indicate that the putative defense system of ferritin that exists in human skin in vivo can be induced by infrared-A radiation and that these wavelengths may prove to be beneficial for human skin. Importantly, following the same doses of IR-A that induced ferritin levels, there was no alteration seen for nuclear DNA type damage, oxidative stress proteins or proteases involved in the degradation of skin. The increased concentrations of this antioxidant in human skin following acute UV radiation could afford increased protection against subsequent oxidative stress.


Asunto(s)
Ferritinas/biosíntesis , Piel/efectos de la radiación , Rayos Ultravioleta , Adulto , Células Cultivadas , Colagenasas/biosíntesis , Daño del ADN , Femenino , Gelatinasas/biosíntesis , Proteínas HSP70 de Choque Térmico/biosíntesis , Hemo Oxigenasa (Desciclizante)/biosíntesis , Humanos , Masculino , Metaloproteinasa 3 de la Matriz/biosíntesis , Persona de Mediana Edad , Óxido Nítrico/biosíntesis , Estrés Oxidativo , Dímeros de Pirimidina/biosíntesis , Piel/citología , Piel/metabolismo , Proteína p53 Supresora de Tumor/biosíntesis
20.
Behav Neurosci ; 111(6): 1335-52, 1997 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-9438802

RESUMEN

Small increments in background noise were shown to increase the amplitude of a subsequently elicited acoustic startle reflex (ASR) in rats by as much as 100% under optimal conditions. Increment lead time (5-160 ms) and level (1.5-15 dB), initial noise level (30-70 dB), startle level (95-125 dB), number of test days (1-5), and drug condition (diazepam or saline ip) were varied in 6 experiments. Prepulse facilitation (PPF), measured by difference scores, was greatest for intermediate increments (3 dB) and lead times (20-40 ms) and was replaced by prepulse inhibition (PPI) for higher values, especially in the later test days. Diazepam reduced baseline ASR and diminished PPI, but it did not affect PPF. These data argue against hypotheses that attribute PPF of this sort to either temporal integration within the ASR pathways or to the elicitation of a nonspecific arousal reaction by the prepulse.


Asunto(s)
Estimulación Acústica , Conducción Nerviosa/fisiología , Inhibición Neural/fisiología , Ruido , Reflejo de Sobresalto/fisiología , Animales , Nivel de Alerta/efectos de los fármacos , Nivel de Alerta/fisiología , Diazepam/farmacología , Moduladores del GABA/farmacología , Hipnóticos y Sedantes/farmacología , Masculino , Conducción Nerviosa/efectos de los fármacos , Inhibición Neural/efectos de los fármacos , Psicoacústica , Ratas , Ratas Endogámicas , Reflejo de Sobresalto/efectos de los fármacos , Factores de Tiempo
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