Arthroscopic and Radiographic Features Distinguish Femoral Head Deformity from Idiopathic Cam, Slipped Capital Femoral Epiphysis, and Recurrent Cam After Slipped Epiphysis.

Introduction: Hip impingement from slipped epiphysis and idiopathic cam is well known but not fully differentiated. Idiopathic cam can be a result of an undiagnosed slip. The mechanism of remodeling of slipped epiphysis deformity has also been controversial. The causes of recurrent femoral head deformity and new impingement beyond progression of the slip have not been studied. Materials and Methods: A consecutive series of hips treated by arthroscopic femoral neck osteoplasty for impingement from slipped epiphysis were compared with a series of hips treated for idiopathic cam impingement. Demographics and clinical, radiographic, and arthroscopic features were retrospectively retrieved. The same parameters were studied in another consecutive series of hips treated for slipped epiphysis and developed recurrent pain from impingement. The deformity was analyzed to understand the causes of recurrence in these hips. The medial most point where the femoral head sphericity ended was called the Alpha point and the tissue covering the bone at the Alpha point was identified. Results: Children with idiopathic cam were older, had less pain and limp, and less clinical deformity compared to those with slipped epiphysis. The damage pattern was chondrolabral separation and acetabular cartilage debonding from the subchondral bone by an articular cartilage covered bump in idiopathic cam impingement, while it was labral crushing and labral and cartilage abrasion by metaphyseal bone in slip impingement. Recurrent cam deformities after initial slips were from epiphyseal extension similar to the idiopathic cam deformity in 7 out of 9 hips. Discussion: Slipped epiphysis and idiopathic cam seem to be distinct entities at the time of presentation. They were different in all findings except for having pain with flexion and internal rotation in both groups. Remodeling of slip deformity seems to occur by wear of the metaphyseal prominence on the acetabulum. Recurrence or worsening of cam deformity in slips occurred by growth of the epiphysis on to the neck anteriorly which can appear as a decrease in the posterior slip. The relationship of the Alpha point to the physeal scar and the tissue covering the femoral head at the Alpha point help differentiate between epiphyseal and metaphyseal cam deformities. Level of Evidence: Level 3 retrospective comparative study.

Cost-effectiveness analysis of cabozantinib compared with everolimus, axitinib, and nivolumab in subsequent line advanced renal cell carcinoma in Japan.

AIMS: The treatment landscape of renal cell carcinoma has changed with the introduction of targeted therapies. While the clinical benefit of cabozantinib is well-established for Japanese patients who have received prior treatment, the economic benefit remains unclear. The objective of this study was to assess the cost-effectiveness of cabozantinib compared with everolimus, axitinib, and nivolumab in patients with advanced renal cell carcinoma who have failed at least one prior therapy in Japan. METHODS: A cost-effectiveness model was developed using a partitioned survival approach and a public healthcare payer's perspective. Over a lifetime horizon, clinical and economic implications were estimated according to a three-health-state structure: progression-free, post-progression, and death. Key clinical inputs and utilities were derived from the METEOR trial, and a de novo network meta-analysis and cost data were obtained from publicly available Japanese data sources. Costs, quality-adjusted life-years, and incremental cost-effectiveness ratios were estimated. Costs and health benefits were discounted annually at 2%. RESULTS: Cabozantinib was more costly and effective compared with everolimus and axitinib, with deterministic incremental cost-effectiveness ratios of ¥5,375,559 and ¥2,223,138, respectively. Compared to nivolumab, cabozantinib was predicted to be less costly and more effective. Sensitivity and scenario analyses demonstrated that the key drivers of cost-effectiveness results were the estimation of overall survival and treatment duration, relative efficacy, drug costs, and subsequent treatment costs. LIMITATIONS: METEOR was an international trial but did not enroll any patients from Japan. Efficacy and safety data from METEOR were used as a proxy for the Japanese population following validation by clinical experts, and alternative assumptions specific to clinical practice in Japan were evaluated in scenario analyses. CONCLUSIONS: In Japan, cabozantinib is a cost-effective alternative to everolimus, axitinib, and nivolumab for the treatment of patients with advanced renal cell carcinoma who have received at least one prior line of therapy.

Open Non-conjoint Bicondylar Hoffa Fracture with Ipsilateral Tibial Spine Avulsion and Disruption of Patellar Tendon - A Rare Case.

Introduction: Hoffa's fracture is rare high velocity injuries. Bicondylar Hoffa is a rare fracture entity with only few reported cases. Case Report: We report a case of open Type 3b non-conjoint bicondylar Hoffa fracture accompanied with ipsilateral anterior tibial spine avulsion and disruption of the patellar tendon. Staged procedure was done, first procedure included wound debridement with external fixator. Second procedure involved definitive fixation of Hoffa fracture, anterior tibial spine, and patellar tendon avulsion. In our case, we have discussed the possible mechanism of injury, operative approaches, and early functional outcome. Conclusion: We report such a case with its possible etiological causation, surgical management, clinical outcome, and prognostic outcome.

Monostotic Paget Disease of the Lumbar Vertebrae: A Pathological Mimicker.

Paget disease is a metabolic disorder involving abnormal bone turnover that consists of 3 phases: the initial lytic phase, the intermediate mixed phase, and the chronic sclerotic phase. Paget disease mostly presents as polyostotic or monostotic lesions of the spine, and is rare on the Indian subcontinent. We present a case of isolated Paget disease of the lumbar third vertebra, which was confirmed only at biopsy. The patient presented with chronic low backache with a developing neurological deficit. We managed the patient with posterior spinal stabilisation, using pedicular screws and vertebroplasty of the collapsed vertebrae to regain the height. Upon the diagnosis of Paget disease, the patient was treated with calcitonin and bisphosphonates for 3 months, along with regular monitoring of alkaline phosphatase levels. Through this case, we hope to emphasize that Paget disease should be considered in the differential diagnosis of lytic lesions. Additionally, the alkaline phosphatase level in this patient was high-normal, which was an aspect of the role of Paget disease as a mimicker. Confirmatory biopsy is mandatory in all lesions.

Unclassified tibial hemimelia.

Tibial hemimelia (congenital longitudinal deficiency of the tibia) is rare (1 in 1 000 000). There are several classifications in the literature. We report an unclassified case of tibial hemimelia. A 6-year-old girl presented with shortening of the right lower limb, with a small rudimentary foot (presence of all toes) and hyper lax ankle. Quadriceps function was excellent. Radiograph showed a partial tibia and fibula in synostosis. The Jones and Kalamachi type 2 classifications both mention similar tibial anomalies; however, the fibula is normal in both varieties. The present variety can be considered as a variant of type 2 tibial hemimelia.

Posttraumatic Static Volar Intercalated Segment Instability - Iatrogenic or Missed Injury.

INTRODUCTION: Carpal instability is broad category consisting of various patterns of injury, with dissociative type more common. CASE REPORT: A 13 -year -old boy presented at 6 months following a fall with restriction of wrist movements. Patient had sustained a closed distal one -third both bones fracture forearm fixed with K -wire, and volar lunate instability was found during sequential follow -up. CONCLUSION: Posttraumatic carpal instability should be identified at the earliest to avoid poor hand function and morbidity associated with it.