[Ocular involvement in Parry-Romberg syndrome]. / Porazhenie organa zreniya pri sindrome Parri­Romberga.

Parry-Romberg syndrome (PRS) is a rare degenerative disease of unknown etiology, characterized by slow progressive hemifacial atrophy of the soft tissues (subcutaneous fat, muscles), cartilage and bones. Beside hemifacial atrophy, various ophthalmic and periocular manifestations of PRS has been described. Progressive enophthalmos and eyelid changes are only some of many other symptoms, as the disease can affect all layers of the eyeball. This article reviews literature on ophthalmic manifestations of PRS and reports our own case and treatment approach for a patient with this pathology.

[Granulomatous inflammation of the orbit as a complication of stem cells injection (case study)]. / Granulematoznoe vospalenie orbity kak oslozhnenie intraorbital'noi in"ektsii stvolovykh kletok (klinicheskoe nablyudenie).

The article present a case report of orbital granulomatous inflammation after a retrobulbar injection of allogenous stem cells. Experimental treatment resulted in an orbital tumor that required surgical excision. Lymphogranulomatous inflammation with a secondary abscess was verified by morphological and immunohistochemical analyses. This case demonstrates the possible dangerous complications of the "off-label" therapy amid the rising popularity of stem cells treatment.

[Biointegration properties of eyelid weight implants made of various materials (experimental study)]. / Osobennosti biointegratsii pal'pebral'nykh implantatov, vypolnennykh iz razlichnykh materialov (eksperimental'noe issledovanie).

Palpebral eyelid weight implants are currently considered as the gold standard method for lagophthalmos correction. Manufactured from different precious metals, they have both benefits and drawbacks. The article presents the results of an experimental morphological study of biointegration of different eyelid weight implants used for correction of paralytic lagophthalmos. PURPOSE: To investigate biointegration properties of implants made of gold, platinum and platinum-gold alloy. MATERIAL AND METHODS: The study enrolled 4 Chinchilla rabbits (8 eyelids). Palpebral implants manufactured of gold, platinum and platinum-gold alloy were placed into the eyelids of the experimental animals. The morphological examination was performed 1 and 6 months after the implantation using paraffin sections. RESULTS: Light microscopy revealed that the implant beds were surrounded by pronounced fibrovascular capsule of uneven thickness over the whole follow-up. The capsule formed after the placement of an implant made of gold and platinum alloy was more loose. However, the emerging connective tissue bridges of the capsule contributed to its immobilization in the tissues and lower risk of extrusion. No signs of an inflammatory and/or allergic reaction were observed in any of the cases. CONCLUSION: The obtained results show that implants made of a 90/10% platinum-gold alloy and 999.9 fine platinum have similar biointegration in terms of morphological features during 6 months of the follow-up period.

[Ophthalmological complications after contour plastic]. / Glaznye oslozhneniya konturnoi plastiki.

Ophthalmological complications after filler injections for aesthetic improvement in various regions of human face are extremely rare. Among them, blindness is considered the most dangerous and almost irreversible. Over 100 cases of vision loss, described by specialists from different countries of Asia, Europe and North America, give evidence that real statistics may be significantly higher. While autologous fat is the most frequent cause of blindness, partial vision recovery was described after hyaluronic acid filler and calcium hydroxyapatite injections. This article attempts to summarize the data from available publications and inform the specialists about the potential risk areas, clinical manifestations, as well as preventive and treatment methods in case such complications do develop.

[Experimental study of hyaluronic acid gel fillers biodegradation in orbit]. / Eksperimental'noe issledovanie biodegradatsii fillerov na osnove gelya gialuronovoi kisloty v orbite.

INTRODUCTION: Recently, hyaluronic acid gel (HAG) fillers were proposed as an effective alternative treatment option for surgical orbital volume augmentation. Several authors reported about long-standing effect of the filler. PURPOSE: To assess the features of HAG biodegradation after intraorbital injection in experimental environment. MATERIAL AND METHODS: In the course of the experiment, 7 chinchilla rabbits (14 eyes) received a single 1ml intraorbital HAG injection (Restylane SubQ, Galderma, Sweden) using a cannula. The animals' orbits were examined by ultrasound scan after the injection and at 1, 3, 6, 9, 12 and 18 months. The animals were subsequently sacrificed for morphological study of orbital tissue containing the HAG filler. RESULTS: The HAG filler persisted in the orbit of experimental animals during the whole follow-up period. The volume of HAG depot and its density diminished gradually till the 18th month, after which the particles of HAG could still be detected with the morphological study and ultrasound. CONCLUSION: The HAG filler persisted in the orbit of experimental animals up to 18 months. Incomplete biodegradation explains the longstanding duration of the injection effect.

[Hyaluronic acid gel implants for correction of pathological conditions of the orbit and eyelids]. / Primenenie in''ektsionnykh implantatov na osnove gelia gialuronovoi kisloty pri patologii vek i orbity.

PURPOSE: To evaluate the effectiveness of injectable implants made of hyaluronic acid gel (HAG) in ophthalmoplastics. MATERIAL AND METHODS: The study included 57 patients (37 patients with lagophthalmos related to acute or chronic facial nerve palsy, endocrine ophthalmopathy; 20 patients with enophthalmos, anophthalmic syndrome). Depending on filler particle size, the patients received either intrapalpebral or intraorbital HAG injection. The biometric measures of palpebral fissure, the position of the eye/implant, and the condition of the cornea were evaluated during the follow-up period (12 months for eyelid and 18 for orbital injection). RESULTS: In the course of the follow-up, all patients showed reliable reduction of lagophthalmos; additionally, improvement of the condition of the cornea was observed in patients after intrapalpebral injection; patients after intraorbital injection exhibited reduction in enophthalmos, upper orbital palpebral fold retraction and upper eyelid excursion. No serious complications have occurred after the injection. CONCLUSION: As minimally invasive method of treating various pathologies of the orbit and eyelids, HAG fillers showed good clinical effectiveness and safety.

[Histopathological study of experimental intrapalpebral injection of hyaluronic acid gel].

UNLABELLED: Hyaluronic acid gel (HAG) fillers are successfully used in the treatment of many eyelid disorders. It is considered that the effect of HAG injection lasts for 6 months on average. However, in our experience volume augmentation persists longer, suggesting that the presence of the filler in the eyelid may be associated with certain tissue reactions. The objective of the study was to investigate morphological features of HAG biodegradation. MATERIAL AND METHODS: Seven adult Chinchilla rabbits (14 eyes) received a single 0.1 ml HAG (Restylane, Q-Med AB, Sweden) subcutaneous upper eyelid injection followed by contouring of the skin for 1.5 mm on average. Tissue samples containing HAG were collected for histopathological examination with morphometric analysis on day 0, week 2, months 1, 2, 4, 6, and 9. RESULTS: HAG persisted subcutaneously in the eyelid during the 9 months of the study in the form of a sponge-like structure with compartments of varying shape and size. Its total volume diminished gradually, nevertheless at the end of the study the filler could still be found in some compartments, mainly peripheral. In the central area of the depot residual HAG was surrounded by optically transparent spaces. CONCLUSION: After being injected subcutaneously into the eyelids of experimental animals HAG formed a sponge-like structure causing a significant increase in eyelids volume. Gradual biodegradation of HAG was accompanied by neocollagenogenesis and 9 months later the process was still ongoing.