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1.
Orthop J Sports Med ; 11(10): 23259671231205240, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-37900867

RESUMEN

Background: The biomechanical properties of the 1.2-mm suture tape have outperformed conventional sutures in previous studies. Purpose: To compare the loop and knot security of 2 tape-type and 1 cord-type sutures using different arthroscopic knot techniques. Study Design: Controlled laboratory study. Methods: The biomechanical characteristics of the 1.2-mm tape, 2.0-mm tape, and 0.5-mm No. 2 suture were compared using 4 different knot types: 2 sliding knots (Samsung Medical Center [SMC] and Tennessee) and 2 nonsliding knots (2-throw surgeon's and 2-throw square) with 2 and 3 additional reverse half-hitches on alternating posts (RHAPs) in a closed-loop system on a materials testing device. Each configuration was tested for loop security (maximal load applied between 0 and 3 mm of displacement), knot security (ultimate failure load), and failure mode with cyclical loading (30 N load for 20 cycles at 1 cycle per sec until failure). Loop and knot security among the configurations were compared using an analysis of variance. Results: With 2 RHAPs, the 2.0-mm tape showed significantly greater loop security than the 1.2-mm tape and suture (P = .001). With 3 RHAPs, the loop security of the suture was significantly superior compared with the 1.2-mm tape (P = .010). Regarding knot security, with 2 RHAPs, the 2.0-mm tape was significantly better than the 1.2-mm tape and suture (P < .001), while with 3 RHAPs, the suture was significantly superior to the 1.2-mm tape (P = .012). Using a square knot with 2 RHAPs, the 2.0-mm tape had significantly greater loop security (P = .001) and better knot security (P = .001) to the 1.2-mm tape and suture. Using the Tennessee knot with 2 RHAPs, the 1.2-mm tape had less loop security (P = .011) and knot security (P = .005) than the suture. Using the SMC knot with 3 RHAPs, the 2.0-mm tape and suture were significantly superior in loop security (P = .001) and knot security (P < .001) to the 1.2-mm tape. There was no significant difference in the failure mode between tapes and sutures with 2 and 3 RHAPs. Conclusion: With 2 RHAPs, the 2.0-mm tape demonstrated greater resistance to suture loop displacement and better knot security compared with the 1.2-mm tape and suture. However, with 3 RHAPs, the 1.2-mm tape manifested weaker loop and knot security compared with the suture.

2.
Gland Surg ; 12(9): 1191-1202, 2023 Sep 25.
Artículo en Inglés | MEDLINE | ID: mdl-37842523

RESUMEN

Background: The transoral endoscopic thyroidectomy vestibular approach (TOETVA) is the most recently developed minimally invasive technique with no skin incision. For tissue dissection and bleeding control, the use of proper energy devices is very important in endoscopic thyroid surgery. To date, there have been no clinical studies reported regarding which energy device is better in TOETVA, ultrasonic shears or advanced bipolar device. The aim of our study is to determine which energy device is more useful for TOETVA. Methods: This study was designed as an open-label, prospective randomized controlled trial in a single university hospital. Patients were randomly assigned to the ultrasonic group or advanced bipolar group before the surgery. From June 2020 to May 2022, 40 patients were enrolled (20 patients were assigned to the ultrasonic group, and 20 patients were assigned to the advanced bipolar group). Primary endpoints were operation time for lobectomy, number of camera cleanings, and blood loss during the lobectomy. Secondary endpoints were pain score, postoperative drainage, and blood chemistry. A single endocrine surgeon had performed all surgeries. Results: There were no significant differences between the two groups in age, sex, body mass index (BMI), tumor location, preoperative cytology, or surgical extent. The time for lobectomy was significantly shorter in the advanced bipolar group (33.8±6.4 vs. 41.9±9.0 minutes, P=0.002). The number of camera cleanings was significantly lower in the advanced bipolar group (2.9±1.6 vs. 5.8±2.5 times, P<0.001). Estimated blood loss was also significantly less in the advanced bipolar group (11.5±17.3 vs. 81.8±99.5 mL, P=0.004). Postoperative hospital stays, drainage, pain score, laboratory findings, and complications were not significantly different between the two groups. Conclusions: According to this study, advanced bipolar device showed better performance, with a shorter operation time, less camera cleaning, and less blood loss. We suggest that advanced bipolar device can be a better choice in TOETVA. Trial Registration: ClinicalTrials.gov identifier: NCT04320901.

3.
Clin Shoulder Elb ; 26(3): 302-305, 2023 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-35545243

RESUMEN

The authors present a case of transient postoperative inferior subluxation of the shoulder after arthroscopic surgical stabilization for recurrent anterior dislocation. The patient was a 61-year-old woman with myasthenia gravis (MG). The first anterior shoulder dislocation occurred because of a fall to the ground. Despite a successful closed reduction, two more dislocations occurred in 3 weeks. Magnetic resonance imaging revealed an anterior labroligamentous periosteal sleeve avulsion (ALPSA) lesion, an engaging Hill-Sachs lesion, and large tears of the supraspinatus and infraspinatus tendons. The patient underwent arthroscopic rotator cuff repair and ALPSA repair with a remplissage procedure. Intraoperatively, no tendency for instability was found; however, a widened glenohumeral joint space and inferior subluxation of the humeral head without functional compromise was observed on the day after surgery and disappeared spontaneously on radiographs 2 weeks later. To the authors' knowledge, this is the first report documenting the occurrence of transient postoperative inferior subluxation of the shoulder in a patient with MG.

4.
Clin Orthop Surg ; 14(3): 426-433, 2022 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-36061853

RESUMEN

Background: The purpose of this study was to compare the initial fixation strength between four different suture methods for the long head of the biceps. Methods: Forty-eight fresh frozen porcine flexor hallucis longus tendons (mean width at suture site, 8.5 ± 0.9 mm) and phalanx bones were randomly assigned to one of the four arthroscopic biceps tenodesis techniques: simple stitch (SS), mattress suture (MS), lasso-loop (LL), and two simple stitches (2SS). A biceps tenodesis was performed according to the four techniques using all-suture type suture anchors (1.9-mm SUTUREFIX anchor with No. 1 ULTRABRAID sutures). Biomechanical evaluations were performed to test load to failure (N), stiffness (N/mm), stress (N/m2), and mode of failure. Results: As for the SS, MS, LL, and 2SS, the mean load to failure was 50.9 ± 14.61 N, 82.3 ± 24.8 N, 116.2 ± 26.7 N, and 130.8 ± 22.5 N (p < 0.001), respectively; mean stiffness was 6.1 ± 1.3 N/mm, 6.7 ± 2.6 N/mm, 7.8 ± 1.4 N/mm, and 8.1 ± 4.2 N/mm, respectively (p = 0.258); and mean stress was 0.7 ± 0.3 N/m2, 1.4 ± 0.8 N/m2, 2.9 ± 0.7 N/m2, and 2.7 ± 0.8 N/m2, respectively (p < 0.001). All the failures happened by the suture cutting through the tendon along its longitudinal fibers. Conclusions: Neither the SS nor the MS method was enough to securely fix the biceps tendon with a significantly lower mechanical strength; however, the 2SS method showed similar initial fixation strength as the LL technique.


Asunto(s)
Tenodesis , Animales , Brazo , Fenómenos Biomecánicos , Humanos , Anclas para Sutura , Técnicas de Sutura , Porcinos , Tenodesis/métodos
5.
J Orthop Sci ; 27(4): 881-886, 2022 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-34154884

RESUMEN

INTRODUCTION: Certain type of injury of the triangular fibrocartilage complex associated with distal radius fracture can result in distal radioulnar joint instability (DRUJ). Untreated DRUJ instability may lead to poor result in the treatment of acute distal radius fractures. The aim of this study was to evaluate DRUJ instability in distal radius fractures through dorsal stress radiography comparing the affected and unaffected wrists intraoperatively. MATERIALS AND METHODS: 49 patients with a distal radius fracture who were operatively treated with a volar locking plate were included. Dorsal stress radiography was used to evaluate both affected and unaffected wrists peri-operatively to detect DRUJ instability. Under general anesthesia, a dorsal stress test was performed on the unaffected wrist. Additionally, after fixation of the affected wrist, a dorsal stress test was performed. The ulnar translation ratio (UTR) was measured through the dorsal stress radiograph. Arthroscopic examination was performed on all affected wrists according to Palmer's and Atzei classification. RESULTS: The UTR of the affected wrist and the TFCC injury Palmer-type IB tendency were positively correlated (odds ratio: 1.18, p-value: 0.002). Additionally, as the UTR difference between the affected and unaffected wrists enlarged, it revealed a significant DRUJ instability tendency due to Palmer-type IB TFCC injury (p-value: 0.000006, Wilcoxon rank-sum test). CONCLUSIONS: Dorsal stress radiography is a reliable, simple procedure to evaluate DRUJ instability intraoperatively. UTR value from dorsal stress radiography could be useful for evaluating DRUJ instability associated with distal radius fracture.


Asunto(s)
Inestabilidad de la Articulación , Fracturas del Radio , Fibrocartílago Triangular , Placas Óseas , Humanos , Inestabilidad de la Articulación/diagnóstico por imagen , Inestabilidad de la Articulación/etiología , Inestabilidad de la Articulación/cirugía , Radiografía , Radio (Anatomía) , Fracturas del Radio/complicaciones , Fracturas del Radio/diagnóstico por imagen , Fracturas del Radio/cirugía , Fibrocartílago Triangular/lesiones , Articulación de la Muñeca/diagnóstico por imagen , Articulación de la Muñeca/cirugía
6.
Am J Sports Med ; 50(14): 3987-3997, 2022 12.
Artículo en Inglés | MEDLINE | ID: mdl-34591715

RESUMEN

BACKGROUND: Superior labral anterior and posterior (SLAP) lesions are common injuries in overhead athletes. As a surgical treatment for SLAP lesions, SLAP repair has been traditionally performed. Recently, biceps tenodesis has been performed as an alternative treatment option; however, there is no review for outcome comparisons between these 2 procedures in overhead athletes. PURPOSE: The aim of this study was to compare the outcomes of SLAP repair versus biceps tenodesis, especially in overhead athletes with SLAP lesions. STUDY DESIGN: Systematic review and meta-analysis; Level of evidence, 4. METHODS: An electronic literature search was performed in Medline, Embase, Scopus, and the Cochrane Library. The studies were appraised using the Methodological Index for Non-randomized Studies (MINORS) tool. Studies that had a minimum follow-up of 2 years, included only patients with SLAP lesions without other major shoulder pathologies, and included only patients who engaged in overhead sports were included. The functional outcomes of the American Shoulder and Elbow Surgeons (ASES) score, rate of return to sport, rate of return to preinjury level of sport, and complication rate were subjected to meta-analysis. RESULTS: A total of 332 articles were identified, and 13 were included in the systematic review. Even though the postoperative ASES scores were slightly higher in the biceps tenodesis group than in the SLAP repair group, no statistically significant differences were found between the groups (biceps tenodesis, 95% CI = 91.71-96.75, I2 = 0.00; SLAP repair, 95% CI = 85.47-94.46, I2 = 16.3; P = .085) The rate of return to sport and the return to preinjury level of sport were slightly higher in the biceps tenodesis group than in the SLAP repair group; however, in meta-analysis these factors did not reach statistical significance (return to sport: biceps tenodesis, 95% CI = 0.66-0.91, I2 = 0.00; SLAP repair, 95% CI = 0.68-0.93, I2 = 70.23; P = .94) (return to preinjury level of sport: biceps tenodesis, 95% CI = 0.61-0.89, I2 = 17.78; SLAP repair, 95% CI = 0.53-0.82, I2 = 58.07; P = .37). The biceps tenodesis group showed a lower complication rate compared with the SLAP repair group without statistical significance (biceps tenodesis, 95% CI = 0.013-0.145, I2 = 0.00; SLAP repair, 95% CI = 0.049-0.143, I2 = 0.00; P = .25). CONCLUSION: The results of biceps tenodesis, compared with SLAP repair, were not inferior in the surgical treatment of overhead athletes with SLAP lesions with regard to the ASES score, rate of return to sport, rate of return to preinjury level of sport, and complication rate. Further high-level, randomized controlled studies are needed to confirm this result.


Asunto(s)
Traumatismos del Brazo , Deportes , Tenodesis , Humanos , Traumatismos del Brazo/cirugía
7.
Orthop J Sports Med ; 9(9): 23259671211022241, 2021 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-34527751

RESUMEN

BACKGROUND: Interposition grafting (IG), also called bridging grafting, and superior capsular reconstruction (SCR) are the most commonly used joint-preserving surgical methods for irreparable rotator cuff tears (RCTs). PURPOSE: To compare the effectiveness of IG versus SCR to treat patients with irreparable RCTs. STUDY DESIGN: Systematic review; Level of evidence, 4. METHODS: A literature search was performed in MEDLINE, Embase, and Scopus. Included in this review were clinical studies evaluating the effect of IG or SCR in patients with irreparable RCTs with a minimum follow-up of 1 year. Various clinical results from the studies were extracted and compared between IG and SCR, and among them, the results of the American Shoulder and Elbow Surgeons score, graft retear rate, and complication rate were included in the meta-analysis. RESULTS: Of 1638 identified articles, 17 (10 studies of IG involving 321 patients and 7 studies of SCR involving 357 patients) were selected. Both surgical methods showed significantly improved clinical outcomes in all but 1 study; however, the IG group had lower pain visual analog scale score, higher Constant score, and bigger active forward flexion and internal rotation compared with the SCR group (all P < .001). The meta-analysis showed no difference in the American Shoulder and Elbow Surgeons score between groups (P = .44), but showed a significantly lower complication rate in the IG group compared with the SCR group (1.12% vs 8.37%, respectively; P < .001). The graft retear rate was not significantly different between groups (IG = 10.64% vs SCR = 12.67%; P = .79). The meta-analysis of graft type indicated no difference between groups in retear rate (autograft: 95% CI, 0.045-0.601; I 2 = 93.28 [IG], 91.27 [SCR]; P = .22; allograft: 95% CI, 0.041-0.216; I 2 = 80.39 [IG], 69.12 [SCR]; P = .64) or complication rate (autograft: 95% CI, 0.009-0.150; I 2 = 0 [IG], 65.89 [SCR]; P = .25; allograft: 95% CI, 0.012-0.081; I 2 = 0 [IG], 30.62 [SCR]; P = .09). CONCLUSION: Both IG and SCR techniques resulted in improvement in patients with irreparable RCTs. Meta-analysis showed a lower complication rate in the IG group; however, the lack of randomized studies limited our conclusions.

8.
Clin Shoulder Elb ; 24(2): 110-113, 2021 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-34078020

RESUMEN

We present an unusual case of bone metastases from renal cell carcinoma around orthopedic implants in a 78-year-old female with osteolytic, expansile, highly vascularized, malignant infiltration around suture anchors in the proximal humerus. The patient had undergone arthroscopic rotator cuff repair using suture anchor implants 6 years previously. After diagnosis of bone metastasis, she was successfully treated with metastasectomy and internal fixation using a plate and screws, with cement augmentation. This report is the first to document metastases around a suture anchor in a bone and suggests the vulnerability of suture anchor implants to tumor metastasis.

9.
Am J Sports Med ; 44(11): 2975-2983, 2016 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-27480980

RESUMEN

BACKGROUND: The modified Broström procedure for chronic lateral ankle instability (CLAI) has presented outstanding clinical results. However, after the procedure, some patients with generalized ligamentous laxity have experienced a recurrence of ankle instability. PURPOSE: To understand the effect of generalized ligamentous laxity on prognosis and risk of recurrence in a cohort of patients with CLAI after the modified Broström procedure. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: A total of 199 ankles from 188 patients underwent the modified Broström procedure for CLAI with a mean follow-up of 60.1 months (range, 48-108 months). Generalized ligamentous laxity was assessed in all patients. The Karlsson-Peterson ankle score (Karlsson score), talar tilt angle, and anterior displacement of the talus were used to evaluate clinical and radiological outcomes. Risk factors associated with clinical outcomes were evaluated using bivariate analysis and logistic regression analysis. Survival outcomes were compared using Kaplan-Meier analysis. RESULTS: Generalized ligamentous laxity was evident in 42 cases (21.1%). The average Karlsson score improved from 54.6 ± 7.1 preoperatively to 87.9 ± 7.2 at last follow-up (P < .001). The presence of generalized ligamentous laxity was significantly associated with poor clinical and radiological outcomes. The rates of clinical failure were 10.8% and 45.2% in the nonlaxity group and the laxity group, respectively (P < .001). According to bivariate analysis, generalized ligamentous laxity, syndesmosis widening, osteochondral lesion of the talus, high preoperative talar tilt angle (>15°), and high preoperative anterior displacement of the talus (>10 mm) were significantly associated with clinical failure. Multivariate logistic regression analysis revealed that generalized ligamentous laxity was the most important independent predictor of clinical failure after the modified Broström procedure. The cumulative success rates for the nonlaxity group were significantly superior to those for the laxity group in Kaplan-Meier curves (P < .001). CONCLUSION: Generalized ligamentous laxity is an independent predictor of poor outcomes and a risk factor of recurrent instability following the modified Broström procedure for CLAI.


Asunto(s)
Articulación del Tobillo/cirugía , Artroplastia/métodos , Inestabilidad de la Articulación/cirugía , Ligamentos Articulares/cirugía , Enfermedades Musculares/etiología , Procedimientos Ortopédicos/métodos , Adolescente , Adulto , Estudios de Cohortes , Femenino , Humanos , Inestabilidad de la Articulación/epidemiología , Masculino , Recurrencia , Estudios Retrospectivos , Factores de Riesgo , Insuficiencia del Tratamiento , Adulto Joven
10.
Arch Oral Biol ; 55(7): 535-40, 2010 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-20444441

RESUMEN

OBJECTIVES: Prevalence and distribution of dental caries in medieval Korean society were evaluated. MATERIALS AND METHODS: Two thousand and nine hundred teeth samples of 126 individuals collected from 16th to 18th century Korean tombs. RESULTS: Preservation status of sample was good. The prevalence of ante- and postmortem tooth loss was 4.4% and 14.2%, respectively. The total caries prevalence was 3.9%. The tooth surface most frequently affected by dental caries was occlusal (4.5%), followed by approximal (2.1%), buccal (1.5%), and lingual (1.1%) surfaces. DISCUSSION: The prevalence of dental caries in Joseon Dynasty skeleton collection was lower than have been found in other collections of similar chronology. The low consumption of refined sugar in medieval Korean society might be a possible explanation, though the technical limitations inherent in such comparison studies preclude definitive conclusions.


Asunto(s)
Caries Dental/historia , Adulto , Factores de Edad , Anciano , Historia Medieval , Humanos , Persona de Mediana Edad , República de Corea , Pérdida de Diente/historia , Adulto Joven
11.
Ann Anat ; 191(3): 309-20, 2009 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-19345566

RESUMEN

Recently, we examined one of the most perfectly preserved mummies of the Joseon Dynasty (1392-1910) ever found in Korea. The individual was an elderly man and a high-ranking general who had lived sometime during the 16th or 17th century in Korea. When computerized tomography (CT) radiographs were taken, a fracture line was observed on the left side of the mandible. A post-factum dissection also provided crucial clues to the cause of death. First of all, blood clots were still evident at the fracture site, indicating that the mandibular fracture had occurred just before death. Second, we also found feces exclusively in the sigmoid colon or rectum, but not in the stomach, small intestine or colon. This told us that our subject had not eaten anything during his final 2 days (even though there was no indication that he would have had any difficulty eating during that time). Therefore, we presume that this case might not be one of chronic or wasting disease, but rather a case of sudden death. By virtue of the varied specialties of the researchers involved in this study, we were able to piece together a partly very clear and partly very plausible story for our 17th century mummy subject. Considering the high level of preservation of remains and artifacts found in lime soil mixture barrier (LSMB) tombs, not to mention the rich supplementary information available from historical documents, similarly successful studies are promised in forthcoming days and years.


Asunto(s)
Momias/patología , Causas de Muerte , Muerte Súbita/patología , Disección , Femenino , Historia del Siglo XVII , Humanos , Corea (Geográfico) , Masculino , Microscopía Electrónica de Rastreo , Personal Militar/historia , Linaje , Piel/patología , Piel/ultraestructura , Tomografía Computarizada por Rayos X
12.
J Parasitol ; 94(2): 467-72, 2008 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-18564747

RESUMEN

It was previously reported that paleoparasitological clues for parasites infecting humans could be found in the feces of mummies of the Joseon Dynasty (1392-1910) in the Republic of Korea. Here, we report the presence of trematode eggs, including Clonorchis sinensis, Metagonimus yokogawai, and Gymnophalloides seoi (a human parasite known in Korea since 1993) in the feces of a recently excavated female mummy in Hadong, Republic of Korea. This is the first report of the discovery of a G. seoi infection in a human mummy. Since Hadong is currently not an endemic area for G. seoi, we speculate that the parasite might have occurred frequently along coastal areas of the Korean peninsula several hundred years ago and that the endemic areas contracted to, more or less, restricted regions since that time.


Asunto(s)
Momias/parasitología , Infecciones por Trematodos/historia , Animales , Heces/parasitología , Historia del Siglo XVII , Humanos , Corea (Geográfico) , Ostreidae/parasitología , Trematodos/aislamiento & purificación , Infecciones por Trematodos/parasitología
13.
J Parasitol ; 93(3): 589-92, 2007 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-17626351

RESUMEN

Previous studies have successfully shown evidence for parasitic infections in human remains from various archaeological sites. However, in the case of Korea, since there have been very few paleoparasitological reports published, pre-20th century parasitic infection patterns remain obscure. Therefore, in order to partly fill this gap, we are reporting on a case of paleoparasitic infection from the feces of a 15th century child mummy from Yangju, Korea. In the course of the present study, we found the eggs of Clonorchis sinensis, Ascaris lumbricoides, and Trichuris trichiura in the feces of the mummy. Trichuris trichiura eggs were found in far greater numbers than other parasite eggs; in fact, intact bipolar plugs were clearly observed and even the larvae were still visible in some eggs. The eggs of C. sinensis and A. lumbricoides were also well preserved, though not in as great a number. Since we could find a number of well-preserved larvae-containing eggs, we are encouraged that successful extraction, amplification, and sequence determination of ancient DNA from the paleoparasite eggs might be possible in future studies. With additional paleoparasitological investigation using feces from Korean mummies, we hope that a history of parasite infection in Korea will be reconstructed.


Asunto(s)
Helmintiasis/historia , Momias/parasitología , Animales , Ascariasis/historia , Ascaris lumbricoides/aislamiento & purificación , Clonorquiasis/historia , Clonorchis sinensis/aislamiento & purificación , Heces/parasitología , Historia del Siglo XV , Humanos , Tricuriasis/historia , Trichuris/aislamiento & purificación
14.
J Anat ; 209(5): 681-8, 2006 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-17062024

RESUMEN

Our previous reports on medieval mummies in Korea have provided information on their preservation status. Because invasive techniques cannot easily be applied when investigating such mummies, the need for non-invasive techniques incurring minimal damage has increased among researchers. Therefore, we wished to confirm whether endoscopy, which has been used in non-invasive and minimally invasive studies of mummies around the world, is an effective tool for study of Korean mummies as well. In conducting an endoscopic investigation on a 15th-century child mummy, we found that well-preserved internal organs remained within the thoracic, abdominal and cranial cavities. The internal organs - including the brain, spinal cord, lung, muscles, liver, heart, intestine, diaphragm and mesentery - were easily investigated by endoscopy. Even the stool of the mummy, which accidentally leaked into the abdominal cavity during an endoscopic biopsy, was clearly observed. In addition, unusual nodules were found on the surface of the intestines and liver. Our current study therefore showed that endoscopic observation could provide an invaluable tool for the palaeo-pathological study of Korean mummies. This technique will continue to be used in the study of medieval mummy cases in the future.


Asunto(s)
Momias/patología , Vísceras/patología , Entierro , Niño , Endoscopía , Heces , Tecnología de Fibra Óptica , Humanos , Intestinos/patología , Corea (Geográfico) , Hígado/patología
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