1.
ACS Med Chem Lett
; 8(1): 128-132, 2017 Jan 12.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28105288
RESUMEN
Herein we report the discovery and hit-to-lead optimization of a series of spirocyclic piperidine aldosterone synthase (CYP11B2) inhibitors. Compounds from this series display potent CYP11B2 inhibition, good selectivity versus related CYP enzymes, and lead-like physical and pharmacokinetic properties.