Detalles de la búsqueda
1.
Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid.
Drug Metab Dispos;
50(8): 1077-1086, 2022 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-35636769
2.
Azatricyclic Inverse Agonists of RORγt That Demonstrate Efficacy in Models of Rheumatoid Arthritis and Psoriasis.
ACS Med Chem Lett;
12(5): 827-835, 2021 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-34055233
3.
Quantification of surrogate monoclonal antibodies in mouse serum using LC-MS/MS.
Bioanalysis;
13(3): 147-159, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33543654
4.
Tricyclic-Carbocyclic RORγt Inverse Agonists-Discovery of BMS-986313.
J Med Chem;
64(5): 2714-2724, 2021 03 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33591748
5.
Novel Tricyclic Pyroglutamide Derivatives as Potent RORγt Inverse Agonists Identified using a Virtual Screening Approach.
ACS Med Chem Lett;
11(12): 2510-2518, 2020 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33335675
6.
Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches.
J Med Chem;
63(23): 15050-15071, 2020 12 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33261314
7.
Tricyclic sulfones as potent, selective and efficacious RORγt inverse agonists - Exploring C6 and C8 SAR using late-stage functionalization.
Bioorg Med Chem Lett;
30(23): 127521, 2020 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32882417
8.
Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.
J Pharmacol Exp Ther;
375(1): 139-151, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32719071
9.
Rationally Designed, Conformationally Constrained Inverse Agonists of RORγt-Identification of a Potent, Selective Series with Biologic-Like in Vivo Efficacy.
J Med Chem;
62(21): 9931-9946, 2019 11 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31638797
10.
Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists.
ACS Med Chem Lett;
10(3): 367-373, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891142
11.
Identification of Tricyclic Agonists of Sphingosine-1-phosphate Receptor 1 (S1P1) Employing Ligand-Based Drug Design.
J Med Chem;
59(21): 9837-9854, 2016 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27726358
12.
Identification and synthesis of potent and selective pyridyl-isoxazole based agonists of sphingosine-1-phosphate 1 (S1P1).
Bioorg Med Chem Lett;
26(10): 2470-2474, 2016 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27055941
13.
Potent and Selective Agonists of Sphingosine 1-Phosphate 1 (S1P1): Discovery and SAR of a Novel Isoxazole Based Series.
J Med Chem;
59(6): 2820-40, 2016 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26924461
14.
Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor.
J Med Chem;
58(19): 7775-84, 2015 Oct 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26359680
15.
Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
J Pharmacol Exp Ther;
354(2): 152-65, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26015463
16.
Quantification of human mAbs in mouse tissues using generic affinity enrichment procedures and LC-MS detection.
Bioanalysis;
6(13): 1795-811, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25157486
17.
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett;
21(15): 4633-7, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21705217
18.
Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
J Med Chem;
53(18): 6629-39, 2010 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-20804198
19.
An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
J Immunol;
184(7): 3917-26, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20190141
20.
The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Bioorg Med Chem Lett;
18(6): 1762-7, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18313298