Detalles de la búsqueda
1.
Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK.
ACS Med Chem Lett;
11(11): 2195-2203, 2020 Nov 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33214829
2.
Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
J Med Chem;
62(7): 3228-3250, 2019 04 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30893553
3.
Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care.
PLoS One;
12(7): e0181782, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28742141
4.
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
J Med Chem;
60(12): 5193-5208, 2017 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28541707
5.
Discovery of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett;
27(4): 855-861, 2017 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28108251
6.
Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers.
J Med Chem;
59(19): 9173-9200, 2016 10 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27583770
7.
Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).
J Med Chem;
59(17): 7915-35, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27531604
8.
Discovery and SAR of pyrrolo[2,1-f][1,2,4]triazin-4-amines as potent and selective PI3Kδ inhibitors.
Bioorg Med Chem Lett;
26(17): 4256-60, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27476421
9.
Dual Inhibition of Interleukin-23 and Interleukin-17 Offers Superior Efficacy in Mouse Models of Autoimmunity.
J Pharmacol Exp Ther;
354(2): 152-65, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26015463
10.
Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
J Med Chem;
53(9): 3814-30, 2010 May 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-20405922
11.
An LFA-1 (alphaLbeta2) small-molecule antagonist reduces inflammation and joint destruction in murine models of arthritis.
J Immunol;
184(7): 3917-26, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20190141
12.
Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.
J Med Chem;
49(24): 6946-9, 2006 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-17125246
13.
De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.
Bioorg Med Chem Lett;
15(4): 1161-4, 2005 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15686933
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