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1.
Quantification of surrogate monoclonal antibodies in mouse serum using LC-MS/MS.
Bioanalysis;
13(3): 147-159, 2021 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33543654
2.
A peptide immunoaffinity LC-MS/MS strategy for quantifying the GPCR protein, S1PR1 in human colon biopsies.
Bioanalysis;
12(18): 1311-1324, 2020 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-32945691
3.
Immunoaffinity microflow liquid chromatography/tandem mass spectrometry for the quantitation of PD1 and PD-L1 in human tumor tissues.
Rapid Commun Mass Spectrom;
34(20): e8896, 2020 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32666620
4.
LC/MS/MS-based quantitation of pig and human S100A1 protein in cardiac tissues: Application to gene therapy.
Anal Biochem;
602: 113766, 2020 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32389692
5.
Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11ß-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J Med Chem;
60(12): 4932-4948, 2017 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28537398
6.
Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase δ (PI3Kδ) Inhibitor for the Treatment of Immunological Disorders.
J Med Chem;
60(12): 5193-5208, 2017 06 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-28541707
7.
Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS.
Bioanalysis;
8(15): 1611-1622, 2016 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-27397670
8.
Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.
ACS Med Chem Lett;
6(8): 850-5, 2015 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-26288683
9.
Quantification of human mAbs in mouse tissues using generic affinity enrichment procedures and LC-MS detection.
Bioanalysis;
6(13): 1795-811, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25157486
10.
Synthesis and structure-activity relationship of 2-adamantylmethyl tetrazoles as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1).
Bioorg Med Chem Lett;
24(2): 654-60, 2014 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24360604
11.
Pellet digestion: a simple and efficient sample preparation technique for LC-MS/MS quantification of large therapeutic proteins in plasma.
Bioanalysis;
4(1): 17-28, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22191591
12.
Quantitation of therapeutic proteins following direct trypsin digestion of dried blood spot samples and detection by LC-MS-based bioanalytical methods in drug discovery.
Bioanalysis;
4(1): 29-40, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22191592
13.
Design, synthesis, and SAR studies of novel polycyclic acids as potent and selective inhibitors of human 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1).
Bioorg Med Chem Lett;
21(22): 6699-704, 2011 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21983439
14.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).
Bioorg Med Chem Lett;
21(22): 6693-8, 2011 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21983444
15.
Development of a canine model to enable the preclinical assessment of pH-dependent absorption of test compounds.
J Pharm Sci;
100(7): 2979-88, 2011 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-21254068
16.
Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2.
J Pharm Sci;
99(8): 3579-93, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20166197
17.
Prediction of in vivo enantiomeric compositions by modeling in vitro metabolic profiles.
J Pharm Sci;
99(7): 3234-45, 2010 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-20112434
18.
5-((4-Aminopiperidin-1-yl)methyl)pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Bioorg Med Chem Lett;
17(17): 4947-54, 2007 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17606372
19.
Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta lowering activity in a transgenic mouse model of Alzheimer's disease.
Bioorg Med Chem Lett;
17(14): 4006-11, 2007 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17502137
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