Detalles de la búsqueda
1.
Discovery of a novel BTK inhibitor S-016 and identification of a new strategy for the treatment of lymphomas including BTK inhibitor-resistant lymphomas.
Acta Pharmacol Sin;
2024 Jun 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-38834683
2.
Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3'-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury.
J Med Chem;
67(8): 6268-6291, 2024 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38619191
3.
Discovery of a Highly Potent Oxysterol Receptor GPR183 Antagonist Bearing the Benzo[d]thiazole Structural Motif for the Treatment of Inflammatory Bowel Disease (IBD).
J Med Chem;
67(5): 3520-3541, 2024 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-38417036
4.
Design, Synthesis, and Pharmacological Evaluation of Isoindoline Analogues as New HPK1 Inhibitors.
J Med Chem;
66(23): 16201-16221, 2023 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-37990878
5.
Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors.
J Med Chem;
66(2): 1634-1651, 2023 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36642961
6.
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance.
EMBO Mol Med;
15(3): e16235, 2023 03 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36652375
7.
Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists.
Eur J Med Chem;
241: 114627, 2022 Nov 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-35963129
8.
Synthesis of aryldifluoromethyl aryl ethers via nickel-catalyzed suzuki cross-coupling between aryloxydifluoromethyl bromides and boronic acids.
Commun Chem;
5(1): 78, 2022 Jul 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36697792
9.
Design, Synthesis, and Pharmacological Evaluation of Biaryl-Containing PD-1/PD-L1 Interaction Inhibitors Bearing a Unique Difluoromethyleneoxy Linkage.
J Med Chem;
64(22): 16687-16702, 2021 11 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-34761679
10.
Synthesis and pharmacological evaluation of choroquine derivatives bearing long aminated side chains as antivirus and anti-inflammatory agents.
Bioorg Chem;
116: 105346, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34536929
11.
Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists.
J Med Chem;
64(3): 1649-1669, 2021 02 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-33470814
12.
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis.
Acta Pharmacol Sin;
42(10): 1653-1664, 2021 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-33441995
13.
Design, synthesis and pharmacological evaluation of bicyclic and tetracyclic pyridopyrimidinone analogues as new KRASG12C inhibitors.
Eur J Med Chem;
213: 113082, 2021 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33309163
14.
Small molecules targeting the innate immune cGASâSTINGâTBK1 signaling pathway.
Acta Pharm Sin B;
10(12): 2272-2298, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-33354501
15.
Corrigendum to "Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core" [Bioorg. Med. Chem. Lett. 26 (2016) 5399-5402].
Bioorg Med Chem Lett;
30(4): 126931, 2020 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31902709
16.
Small-Molecule Immuno-Oncology Therapy: Advances, Challenges and New Directions.
Curr Top Med Chem;
19(3): 180-185, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30854972
17.
Discovery of a potent tyrosine kinase AXL inhibitor bearing the 3-((2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)amino)pyrazine core.
Bioorg Med Chem Lett;
29(6): 836-838, 2019 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30685094
18.
Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors.
Eur J Med Chem;
154: 9-28, 2018 Jun 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29775937
19.
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors.
J Med Chem;
61(10): 4608-4627, 2018 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-29715023
20.
Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs.
Eur J Med Chem;
152: 76-86, 2018 May 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-29698859