RESUMEN
Indications for TF-TAVI (transfemoral transcatheter aortic valve implantation) are rapidly changing according to increasing evidence from randomized controlled trials. Present trials document the non-inferiority or even superiority of TF-TAVI in intermediate-risk patients (STS-Score 4-8%) as well as in low-risk patients (STS-Score < 4%). However, risk scores exhibit limitations and, as a single criterion, are unable to establish an appropriate indication of TF-TAVI vs transapical TAVI vs SAVR (surgical aortic valve replacement). The ESC (European Society of Cardiology)/EACTS (European Association for Cardio-Thoracic Surgery) guidelines 2017 and the German DGK (Deutsche Gesellschaft für Kardiologie)/DGTHG (Deutsche Gesellschaft für Thorax-, Herz- und Gefäßchirurgie) commentary 2018 offer a framework for the selection of the best therapeutic method, but the individual decision is left to the discretion of the heart teams. An interdisciplinary TAVI consensus group of interventional cardiologists of the ALKK (Arbeitsgemeinschaft Leitende Kardiologische Krankenhausärzte e.V.) and cardiac surgeons has developed a detailed consensus on the indications for TF-TAVI to provide an up-to-date, evidence-based, comprehensive decision matrix for daily practice. The matrix of indication criteria includes age, risk scores, contraindications against SAVR (e.g., porcelain aorta), cardiovascular criteria pro TAVI, additional criteria pro TAVI (e.g., frailty, comorbidities, organ dysfunction), contraindications against TAVI (e.g., endocarditis) and cardiovascular criteria pro SAVR (e.g., bicuspid valve anatomy). This interdisciplinary consensus may provide orientation to heart teams for individual TAVI-indication decisions. Future adaptations according to evolving medical evidence are to be expected. Interdisciplinary consensus on indications for transfemoral transcatheter aortic valve implantation (TF-TAVI).
Asunto(s)
Estenosis de la Válvula Aórtica/cirugía , Reemplazo de la Válvula Aórtica Transcatéter/métodos , Consenso , Arteria Femoral , Humanos , Selección de Paciente , Ensayos Clínicos Controlados Aleatorios como AsuntoRESUMEN
Arterial hypertension represents one of the most frequent chronic diseases that can lead to complications, such as stroke, dementia, heart attack, heart failure and renal failure. By 2025 the number of hypertensive patients will increase to approximately 1.6 billion people worldwide. The new guidelines of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH) on the management of arterial hypertension replace the guidelines of the ESC/ESH from 2013. The 2018 guidelines of the ESC/ESH were adopted by the German Cardiac Society and the German Hypertension League. In these comments national characteristics are worked out and the essential new aspects of the guidelines are critically discussed. These include, for example, the definition of hypertension, the importance of out of office blood pressure measurements, revised blood pressure targets, the modified algorithm for drug treatment and the relevance of device-based hypertension treatments. Important aspects for the management of hypertensive emergencies are also presented.
Asunto(s)
Cardiología , Hipertensión , Antihipertensivos , Presión Sanguínea , Determinación de la Presión Sanguínea , HumanosRESUMEN
Increasing complexity and new highly differentiated therapeutic procedures in cardiology result in a need for additional training beyond cardiology board certification. The German Cardiac Society therefore developed a variety of certifications of educational curricula and definition of specialized centers. Standardization and structuring in education and patient treatment, as defined by certifications may be helpful; however, introduction of certification can have serious consequences for hospital structure, the side effects of which may impair quality of treatment for individual patients. The current article discusses these issues against the background of the following questions: how is quality defined? How do certifications interfere with patient care on a nationwide level, how do they influence responsibilities and teamwork? Are there conflicts of interests by designing certifications and how good are the organizational structures? Finally, suggestions are made on what has to be considered when designing certifications. Certifications should acknowledge all cardiologists, irrespective of their position in the level of care. There should be a coherent unified concept synchronizing all certifications and administration needs to be transparent and well structured.
Asunto(s)
Cardiología , Certificación , Cardiología/normas , HumanosRESUMEN
Although pacemakers and implantable defibrillators have become the standard treatment of bradycardic and tachycardic arrhythmias, long-term complications caused by the transvenously inserted pacing and defibrillation leads, such as electrode fracture, lead infection and tricuspid valve insufficiency are not uncommonly observed. Therefore, leadless pacemakers and purely subcutaneously implantable cardioverter defibrillators (S-ICDs) have been developed in recent years, which are implanted without transvenous electrodes with the aim to reduce long-term complications with these devices; however, currently available leadless pacemakers are limited to single chamber stimulation and SICDs are limited to pure defibrillation without antibradycardic, antitachycardic pacing or cardiac resynchronization capabilities. Thus, these devices cannot yet be used as multichamber pacemakers or defibrillators even though in these circumstances a higher complication rate is to be expected due to the multiple number of transvenous leads. This article summarizes the current state of knowledge on leadless pacemakers and ICDs, discusses the limitations of these devices and provides an outlook into their future development.
Asunto(s)
Estimulación Cardíaca Artificial , Terapia de Resincronización Cardíaca/métodos , Desfibriladores Implantables , Marcapaso Artificial , Arritmias Cardíacas/terapia , Diseño de Equipo , Humanos , TaquicardiaRESUMEN
This article aims to give an overview over important articles in the field of implantable cardioverter defibrillator (ICD) therapy in 2012. Important publications concern analyses on therapy efficacy and safety of the subcutaneous ICD, gender-specific differences in the complication rate and prognosis after ICD implantation, the necessity of intraoperative testing of the defibrillation threshold and the impact of preventive measures to reduce ICD therapies on prognosis after device implantation. The relevance of the study findings for daily clinical practice is briefly discussed.
Asunto(s)
Arritmias Cardíacas/diagnóstico , Arritmias Cardíacas/prevención & control , Desfibriladores Implantables , Medicina Basada en la Evidencia , Selección de Paciente , Humanos , Resultado del TratamientoAsunto(s)
Terapia de Resincronización Cardíaca , Disfunción Ventricular Izquierda/terapia , Gasto Cardíaco Bajo/diagnóstico , Gasto Cardíaco Bajo/mortalidad , Gasto Cardíaco Bajo/fisiopatología , Gasto Cardíaco Bajo/terapia , Ensayos Clínicos como Asunto , Diseño de Equipo , Humanos , Guías de Práctica Clínica como Asunto , Tasa de Supervivencia , Disfunción Ventricular Izquierda/diagnóstico , Disfunción Ventricular Izquierda/mortalidad , Disfunción Ventricular Izquierda/fisiopatologíaRESUMEN
AIMS: Little is known about the incidence of paroxysmal atrial tachycardias (PAT) in patients with heart failure (HF). The availability of cardiac resynchronization therapy (CRT) devices with extended diagnostics for AT enables continuous monitoring of PAT episodes. The aim of the study was to assess the incidence over time of PAT in HF patients treated with CRT. METHODS AND RESULTS: Consecutive patients in NYHA functional class III or IV despite optimal drug therapy, QRS duration > or = 130 ms, left ventricular ejection fraction < or = 35%, and left ventricular end-diastolic dimension > or = 55 mm were eligible for enrolment. Patients with permanent or persistent atrial fibrillation (AF) were not included in the study. The first follow-up examination was performed 2 weeks after implantation, to optimize atrial sensing and CRT. Subsequent follow-up examinations were carried out 15 and 28 weeks after implantation, to collect the telemetric data. A total of 173 patients (67 +/- 11 years, M 116) were enrolled. Complete arrhythmia monitoring data were available from 120 patients over a mean follow-up of 183 +/- 23 days. Atrial tachycardia episodes were detected through telemetry in 25 of 120 patients (21%) during at least one follow-up examination. Atrial tachycardia episodes were recorded in 29 and 17% (P = NS) of patients with and without previous history of AF, respectively. CONCLUSION: More than 20% of the overall HF patient population treated with CRT suffer PAT episodes. Paroxysmal atrial tachycardia may interfere with response to CRT. Therefore, telemetric data may be relevant to drive the appropriate therapy in each patient.
Asunto(s)
Fibrilación Atrial/epidemiología , Fibrilación Atrial/prevención & control , Estimulación Cardíaca Artificial/estadística & datos numéricos , Electrocardiografía Ambulatoria/estadística & datos numéricos , Insuficiencia Cardíaca/epidemiología , Insuficiencia Cardíaca/prevención & control , Anciano , Fibrilación Atrial/diagnóstico , Comorbilidad , Europa (Continente)/epidemiología , Femenino , Insuficiencia Cardíaca/diagnóstico , Humanos , Incidencia , Masculino , Medición de Riesgo/métodos , Factores de Riesgo , Resultado del TratamientoRESUMEN
Since the first studies on cardiac resynchronization therapy (CRT), the evidence for the benefit of this electrical therapy in heart failure has continuously grown. Thus, CRT has been firmly implemented in current therapy guidelines for heart failure. However, there are distinct differences between the different guidelines published. In addition, indications for CRT are still evolving in certain patient groups. This article aims to give an overview of the current guidelines for CRT and also discusses some of the differences between the different guidelines. It also provides an outlook for potential candidates for CRT in the future where current guidelines do not yet define a clear indication for implantation of such a device.
Asunto(s)
Terapia de Resincronización Cardíaca/normas , Cardiología/normas , Insuficiencia Cardíaca/complicaciones , Insuficiencia Cardíaca/prevención & control , Guías de Práctica Clínica como Asunto , Disfunción Ventricular Izquierda/etiología , Disfunción Ventricular Izquierda/prevención & control , Alemania , HumanosRESUMEN
Cardiac resynchroinsation therapy (CRT) aims to correct the mechanical dyssynchrony in patients with heart failure and broad QRS complex. Until now, indication for CRT is based mainly on clinical and electrocardiographic criteria. Because QRS width is only weakly correlated to mechanical dyssynchrony, imaging techniques such as echocardiography and magnetic resonance tomography (MRT) seem suitable for analysis of dyssynchrony. Echocardiography has been studied in several studies for identification of suitable CRT candidates. Apart from conventional methods such as M mode-, 2 D-, and Doppler echocardiography other techniques which will be discussed in this article, including tissue Doppler echocardiography, have been used. Despite many positive results in individual studies no single echocardiographic parameter was able to predict positive CRT response in a prospective multicenter trial. Thus, QRS width remains the "gold standard" for CRT patient identification at present. In borderline cases, a combination of several echocardiographic measures of dyssynchrony may prove helpful. The results of studies with new techniques such as 2-dimensional strain analysis or 3D-echocardiography remain to be awaited. In the future, MRT may play a bigger role in this setting.
Asunto(s)
Estimulación Cardíaca Artificial/métodos , Ecocardiografía/métodos , Insuficiencia Cardíaca/terapia , Imagen por Resonancia Magnética/métodos , Selección de Paciente , Estimulación Cardíaca Artificial/normas , Ecocardiografía Doppler/métodos , Ecocardiografía Tridimensional/métodos , Humanos , Índice de Severidad de la EnfermedadRESUMEN
Intracardiac conduction disturbances, mostly manifested as a left bundle branch block (LBBB), are common findings in cardiac failure and associated with a poor prognosis. LBBB is a marker of disease progression and also leads to worsened cardiac hemodynamics by dyssynchronous contraction that can accelerate progression of the underlying disease. Cardiac resynchronization therapy (CRT) can reduce the negative effects of these disturbances leading to improvement in hemodynamics and long-term improvement in cardiopulmonary exercise tolerance, reduction of left ventricular volumes and functional mitral regurgitation. Prospective multicenter studies, such as the CARE-HF and COMPANION trials have demonstrated reduced mortality with CRT or combined treatment with defibrillator capability (CRT-D). Thus, CRT has been adopted in the current guidelines of cardiology societies. Nevertheless, there are a number of open issues with CRT, such as the high number of non-responders or the value of CRT in patients with atrial fibrillation, narrow QRS complex and mild cardiac failure or asymptomatic left ventricular dysfunction. In addition, the question whether every CRT patient needs a device with defibrillating capabilities is not fully resolved, at least for patients with dilative cardiomyopathy.
Asunto(s)
Bloqueo de Rama/complicaciones , Bloqueo de Rama/terapia , Estimulación Cardíaca Artificial/métodos , Cardioversión Eléctrica/métodos , Insuficiencia Cardíaca/complicaciones , Insuficiencia Cardíaca/terapia , HumanosRESUMEN
BACKGROUND: Relatively few reports on the clinical impact of atrial fibrillation (AF) in hypertrophic obstructive cardiomyopathy (HOCM) are available. The aims of our study are to report the effect of transcoronary ablation of septal hypertrophy (TASH) on clinical outcome in HOCM associated with AF and to evaluate the influence of AF on symptoms and quality of life in HOCM. PATIENT AND METHODS: In 80 consecutive patients (38 f, mean age 56 +/- 17 years) with severely symptomatic HOCM referred for interventional treatment, we analyzed the prevalence of AF based on 240 Holter ECG recordings and patients' history, retrospectively. Symptoms, quality of life, number of hospital admissions and hemodynamic performance were obtained in all patients before and after TASH. Mortality was additionally investigated by letter and telephone contact. RESULTS: The overall prevalence of AF was 29%. Paroxysmal AF was detected in 17 pts (21.3%), persistent AF in 5 pts (6.3%). Only 1 pt (1.3%) suffered from permanent AF. Symptoms due to AF were present in 52.6% of the AF patients. Quality of life score was markedly improved after TASH (15.9 +/- 3.8 vs. 20.7 +/- 3.8, p < 0.001) with no difference between sinus rhythm and atrial fibrillation. However, hospital admissions were more frequent in the AF group (0.85 +/- 1.84 vs. 0.28 +/- 0.81, p = 0.03) in 32 +/- 13 months. AF patients suffered more often from syncope before TASH (30 +/- 70% vs. 10 +/- 30%, p = 0.008). Two patients with sinus rhythm at baseline died after 32 +/- 13 months from cardiovascular cause. CONCLUSIONS: Atrial fibrillation is the major cardiac arrhythmia in severe HOCM. The majority of AF patients demonstrate AF specific symptoms. The paroxysmal type of atrial fibrillation dominates by far. Both patients with and without atrial fibrillation showed similar quality of life with marked improvement after TASH.
Asunto(s)
Fibrilación Atrial/epidemiología , Fibrilación Atrial/prevención & control , Cardiomiopatía Hipertrófica/epidemiología , Cardiomiopatía Hipertrófica/terapia , Etanol/uso terapéutico , Calidad de Vida , Fibrilación Atrial/diagnóstico , Cardiomiopatía Hipertrófica/diagnóstico , Femenino , Alemania/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Prevalencia , Medición de Riesgo/métodos , Factores de Riesgo , Resultado del TratamientoRESUMEN
In the past decade molecular genetic analysis has greatly expanded our knowledge about inherited arrhythmogenic syndromes. The congenital long QT syndrome (LQTS) and the recently described short QT syndrome (SQTS), with the defining characteristic of abnormal prolongation or shortening of the QTc interval on the surface electrocardiogram, are caused by cardiac ion channel dysfunctions. These "channelopathies" show a high degree of genetic heterogeneity of the molecular pathways in terms of the relationships between genetic defects and phenotypic expression. In this brief review we summarize the current understanding of the molecular basis of long and short QT syndrome with focus on the impact of molecular genetics on the clinical management of these diseases.
Asunto(s)
Canalopatías/genética , Electrocardiografía , Síndrome de QT Prolongado/genética , Taquicardia Supraventricular/genética , Mapeo Cromosómico , Muerte Súbita Cardíaca/etiología , Muerte Súbita Cardíaca/prevención & control , Tamización de Portadores Genéticos , Predisposición Genética a la Enfermedad/genética , Pruebas Genéticas , Genotipo , Humanos , FenotipoRESUMEN
Due to the increasing number of patients and complexity of modern tachycardia devices, efficient therapy surveillance as offered by Home Monitoring (HM) is of increasing importance. We report of an ICD patient with incessant ventricular tachycardia, in whom immediate arrhythmia transmission by HM permitted hospitalization and change of medication without time delay.
Asunto(s)
Cardioversión Eléctrica/métodos , Electrocardiografía Ambulatoria/métodos , Servicios de Atención de Salud a Domicilio , Taquicardia Ventricular/diagnóstico , Taquicardia Ventricular/prevención & control , Telemedicina/métodos , Terapia Asistida por Computador/métodos , Anciano , Desfibriladores Implantables , Diagnóstico por Computador/métodos , Humanos , Masculino , Prevención Secundaria , Resultado del TratamientoRESUMEN
Brain natriuretic peptide (BNP) release is a marker of increased myocardial wall tension, which is elevated in patients with disturbed left ventricular function. As it is increasingly being used as a reliable marker for diagnosis, optimization of pharmacological treatment, and risk stratification, BNP measurement might be also relevant for patients undergoing cardiac surgery. Measured BNP levels can be used to predict postoperative complications and the risk of further cardiac events. Preoperative BNP levels support the decision for the timing of aortic valve replacement in asymptomatic severe aortic stenosis. An increase in BNP levels early predicts allograft rejection after cardiac transplantation or ineffective cardiac resynchronization therapy. Moreover, BNP levels can be used to differentiate between cardiac and non-cardiac reasons for acute dyspnea in the management of surgical patients. Finally, the application of recombinant human BNP seems to improve recovery after cardiac surgical procedures. Thus, BNP can be a helpful tool for monitoring and treating patients before, during, and after cardiac surgery to predict and improve the effectiveness of therapy and reduce hospitalization and costs.
Asunto(s)
Procedimientos Quirúrgicos Cardíacos , Péptido Natriurético Encefálico/sangre , Puente de Arteria Coronaria , Rechazo de Injerto/sangre , Insuficiencia Cardíaca/sangre , Trasplante de Corazón/fisiología , Humanos , Natriuréticos/uso terapéutico , Péptido Natriurético Encefálico/metabolismo , Péptido Natriurético Encefálico/fisiología , Péptido Natriurético Encefálico/uso terapéutico , Pronóstico , Sensibilidad y Especificidad , Disfunción Ventricular Izquierda/sangreAsunto(s)
Arritmias Cardíacas/etiología , Arritmias Cardíacas/prevención & control , Estimulación Cardíaca Artificial/métodos , Estimulación Cardíaca Artificial/tendencias , Insuficiencia Cardíaca/terapia , Disfunción Ventricular Izquierda/prevención & control , Insuficiencia Cardíaca/complicaciones , Humanos , Disfunción Ventricular Izquierda/etiologíaRESUMEN
Tachyarrhythmias represent a frequent problem in intensive care medicine. However, considerable uncertainty prevails among physicians regarding optimal pharmacotherapy, due also to numerous negative study results on chronic antiarrhythmic therapy. Moreover, in an emergency situation, the physician faces the dilemma of treating a potentially life-threatening arrhythmia as quickly as possible while simultaneously ensuring adequate diagnostic work-up, which will be decisive for long-term therapy once the patient has survived the crisis. The differential diagnosis between supraventricular and ventricular tachycardias is primarily facilitated by knowledge of a few salient points from the patient's history and 12-lead electrocardiography. This overview presents the most important principles for treating these arrhythmias. Interventional therapy principles (overstimulation, ablation) play an increasing role in these considerations. New insights on the pathogenesis of "malignant" arrhythmias and implementation of new concepts such as defibrillation by lay responders with the automatic external defibrillator will substantially influence emergency treatment of tachyarrhythmias in the coming years.
Asunto(s)
Fibrilación Atrial/terapia , Taquicardia Ventricular/terapia , Antiarrítmicos/administración & dosificación , Fibrilación Atrial/etiología , Fibrilación Atrial/mortalidad , Ablación por Catéter , Terapia Combinada , Unidades de Cuidados Coronarios , Desfibriladores , Cardioversión Eléctrica , Electrocardiografía , Mortalidad Hospitalaria , Humanos , Pronóstico , Taquicardia Ventricular/etiología , Taquicardia Ventricular/mortalidadAsunto(s)
Bloqueo de Rama/terapia , Desfibriladores Implantables , Marcapaso Artificial , Taquicardia Ventricular/terapia , Bloqueo de Rama/etiología , Bloqueo de Rama/fisiopatología , Electrocardiografía , Electrodos Implantados , Insuficiencia Cardíaca/fisiopatología , Insuficiencia Cardíaca/terapia , Humanos , Evaluación de Procesos y Resultados en Atención de Salud , Ensayos Clínicos Controlados Aleatorios como Asunto , Taquicardia Ventricular/etiología , Taquicardia Ventricular/fisiopatologíaRESUMEN
A clinical study investigates the use of Home Monitoring (HM) in pacemaker therapy. For 3 months patients are supervised by daily automatic HM messages. Endpoints are the technical feasibility and the clinical benefit of HM. Ninety three patients have currently been included and followed for 72 +/- 30 days. Three patients were excluded due to insufficient mobile net coverage at their living sites. For the other patients, 5311 of 5911 messages were successfully registered. Interrupts in the sequence of messages occurred 331 times. Two hundred ten of these (63%) lasted just 1 day, 14 interrupts (4%) lasted 5 or more days. Two patients did not show any interrupts, 34 patients (38%) had interrupts of 3 and more days. The clinical benefit of Home Monitoring was found in the remote detection of arrhythmia and lead dislocation.