Prevalence of and risk factors for depressive symptoms in non-tuberculous mycobacterial pulmonary disease.

BACKGROUND: The presence of depressive symptoms in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD) is an important research topic; however, the prevalence of depressive symptoms and the factors that influence their development are unclear.OBJECTIVE: To analyse the association between CES-D (Center for Epidemiological Studies Depression Scale) scores and clinical parameters such as age, disease duration, pulmonary function, imaging findings, blood data, physical functions, sleep disturbances, respiratory symptoms and health-related quality of life (HRQOL).METHODS: We conducted a cross-sectional retrospective study of 114 patients with NTM-PD at a single centre from March 2016 to January 2021 to evaluate the relationship between CES-D scores and clinical parameters.RESULTS: Participants had a median age of 64 years; 32.5% of them had depressive symptoms. Disease duration, albumin, C-reactive protein, pulmonary function, dyspnoea, exercise capacity, respiratory symptoms, cough-related HRQOL and sleep disturbances were associated with depressive symptoms. Binomial logistic regression analyses indicated that the CES-D score was significantly associated with cough-related HRQOL and sleep disturbances.CONCLUSION: A high percentage of NTM-PD patients in this study experienced depressive symptoms, and these patients had abnormalities of various clinical parameters. Cough-related HRQOL and sleep disturbance had a strong influence on the development of depressive symptoms.

Health-related quality of life associates with clinical parameters in patients with NTM pulmonary disease.

BACKGROUND: Previous studies have shown a reduction in health-related quality of life (HRQoL) in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD). However, the causes of this decline and the factors that contribute to it are unknown. This study was conducted to analyse the association between the St George´s Respiratory Questionnaire (SGRQ) and clinical parameters, including age, disease duration, body composition, pulmonary function, chest X-ray findings, blood data and physical function.METHODS: We performed a single-centre, cross-sectional, retrospective study of 101 patients with NTM-PD from December 2016 to October 2019. The relationship between the SGRQ scores and clinical parameters was evaluated.RESULTS: The median patient age was 67.0 years. Pulmonary function, radiological score, albumin levels, C-reactive protein levels and incremental shuttle walk test distance (ISWD) were significantly correlated with the total and component scores on the SGRQ. Multiple regression analysis showed that the SGRQ score was significantly associated with radiological score, pulmonary function and ISWD.CONCLUSION: This study was the first to assess the effect of clinical parameters on the SGRQ in patients with NTM-PD. HRQoL as determined using the SGRQ was associated with the radiological score, pulmonary function and ISWD in patients with NTM-PD.

Do the kinetics of peripheral muscle oxygenation reflect systemic oxygen intake?

To examine whether the kinetics of local muscle oxygenation reflect systemic oxygen intake, we measured the kinetics of local muscle oxygenation and systemic oxygen consumption (VO2). This study included 16 healthy males who performed an exercise tolerance test on a bicycle ergometer. During the exercise test, expiratory gas analysis was performed with an expiratory gas analyzer, and the kinetics of vastus lateralis muscle oxygenation were determined by near-infrared spectroscopy (NIRS). Oxygenated hemoglobin (OxyHb) and tissue blood oxygen saturation (StO2) gradually decreased during the exercise test, while deoxygenated hemoglobin (DeoxyHb) gradually increased. We examined correlations between the mean values of these parameters, which were calculated by time-integrating the values obtained using NIRS and dividing them by the integral time, and VO2. There was a marked positive correlation between DeoxyHb and VO2 (r = 0.893-0.986), and a marked negative correlation between StO2 and VO2 (r = 0.859-0.995). There was a negative correlation between VO2 and OxyHb (r = 0.726-0.978), and no correlation between TotalHb and VO2. These results suggest that the kinetics of peripheral muscle oxygenation reflect systemic VO2.