RESUMEN
CONTEXT: To find the potential value of Ca3N2 in the field of optoelectronics, the physical properties of Ca3N2 will be analyzed. It can be concluded from the electronic properties that the Ca-N bonds of α-Ca3N2 are more stable than those of δ-Ca3N2 and ε-Ca3N2. The dielectric function, reflectivity function, and absorption function of three types of Ca3N2 were accurately calculated, and it was concluded that α-Ca3N2, δ-Ca3N2, and ε-Ca3N2 have greater transmittance for visible light and exhibit optical transparency in the near-infrared frequency domain. Combined with the high hardness, strong bonding, high melting point, and wear resistance of Ca3N2, Ca3N2 can be used as a new generation of window heat-resistant materials. The α-Ca3N2, δ-Ca3N2, and ε-Ca3N2 are indirect, direct, and indirect narrow bandgap compounds, respectively, that is, δ-Ca3N2 is more suitable for luminescent materials than α-Ca3N2 and ε-Ca3N2. α-Ca3N2 and δ-Ca3N2 have high reflective properties in the ultraviolet region and can be used as UV protective coatings. All three Ca3N2 materials can be used industrially to synthesize photovoltaic devices that operate in the ultraviolet region. METHODS: Based on the first-principles of density functional theory calculations, the structures, electronic properties, and optical properties of α-Ca3N2, δ-Ca3N2, and ε-Ca3N2 were calculated. The calculation results show that although the α-Ca3N2, δ-Ca3N2, and ε-Ca3N2 have similar electronic structures, some phases have better properties in some aspects.
RESUMEN
Spirocyclic hexadienones with multiple stereogenic centers are frequently found in natural products but remain challenging targets to synthesize. Herein, we report the enantioselective desymmetrization of bisphenol derivatives via Ir-catalyzed allylic dearomatization reactions, affording spirocyclic hexadienone derivatives with up to three contiguous stereogenic centers in good yields (up to 90%) and excellent enantioselectivity (up to 99% ee). The high efficiency of this reaction is exemplified by the short reaction time (30 min), low catalyst loading (down to 0.2 mol %), and ability to perform the reaction on a gram-scale. The total syntheses of (+)-tatanan B and (+)-tatanan C were also realized using this Ir-catalyzed allylic dearomatization reaction as a key step.
RESUMEN
The LAH4 family of amphipathic peptides exhibits pronounced antimicrobial, cell penetrating and nucleic acid transfection activities. Furthermore, variants were designed with potent lentiviral transduction enhancement. When viewed along a helical wheel the four histidines are arranged to form an amphipathic structure. In order to optimize some of these biological activities the number of leucine and alanine residues exposed to the hydrophilic surface was systematically varied which resulted in the design of vectofusin a peptide with strong lentiviral transduction enhancement activities. Here the series of peptides with varying numbers of alanine or leucine residues, respectively, framed by the histidines was tested for their calcein release activity. Interestingly, the membrane pore formation and DNA transfection activities show a clear correlation with the hydrophilic angle. In contrast the membrane partitioning and the propensity to adopt helical conformations was hardly affected as long as the hydrophilic angle did not exceed a limiting value of 150°.
Asunto(s)
Péptidos Catiónicos Antimicrobianos/farmacología , ADN/genética , Histidina/genética , Membranas/efectos de los fármacos , Alanina/genética , Péptidos Catiónicos Antimicrobianos/química , Péptidos Catiónicos Antimicrobianos/genética , Línea Celular Tumoral , Péptidos de Penetración Celular/química , Péptidos de Penetración Celular/genética , Péptidos de Penetración Celular/farmacología , ADN/efectos de los fármacos , Humanos , Interacciones Hidrofóbicas e Hidrofílicas/efectos de los fármacos , Lentivirus/genética , Leucina/genética , Membranas/metabolismo , Porosidad , TransfecciónRESUMEN
An enantioselective chemical synthesis of arene cis-dihydrodiols has been realized from 2-pyrones through sequential ytterbium-catalyzed asymmetric inverse-electron-demand Diels-Alder (IEDDA) reaction of 2-pyrones and retro-Diels-Alder extrusion of CO2 . By using this strategy, a series of substituted arene cis-dihydrodiols can be obtained efficiently with high enantioselectivity (>99 % ee in many cases). Based on this strategy, efficient and concise asymmetric total syntheses of (+)-MK7607 and 1-epi-(+)-MK7607 were accomplished.