RESUMEN
Nuclear factor-κB-inducing kinase (NIK) is a new regulator of nuclear factor-κB signaling, which plays an important role in tumorigenesis. This study aimed to examine the expression of NIK in gastric cancer and investigate its clinical significance.Tumor issues were collected from 80 gastric cancer patients who received surgery and the diagnosis was confirmed by postoperative pathological analysis. The expression of NIK in gastric cancer tissues and adjacent normal mucosa was detected by immunohistochemical analysis. The associations between NIK expression and clinicopathological features of the patients were further analyzed.NIK expression was significantly higher in gastric cancer tissues than in adjacent normal tissues (Pâ<â.05). Furthermore, NIK expression showed significant association with UICC stage, T status, and differentiation, but not with age and gender of gastric cancer patients.NIK is overexpressed in gastric cancer and is a potential diagnostic marker of gastric cancer.
Asunto(s)
Proteínas Serina-Treonina Quinasas/metabolismo , Neoplasias Gástricas/enzimología , Anciano , Biomarcadores de Tumor/metabolismo , Femenino , Humanos , Técnicas para Inmunoenzimas , Masculino , Persona de Mediana Edad , Estadificación de Neoplasias , Neoplasias Gástricas/patología , Neoplasias Gástricas/cirugía , Quinasa de Factor Nuclear kappa BRESUMEN
OBJECTIVE: Hepatitis E virus (HEV) infection is responsible for over 50% of acute viral hepatitis cases, and the blood transfusion route has emerged as a possible means of sporadic HEV infection. The aim of this study was to determine the seroprevalence of HEV among blood donors in East China. METHODS: Blood samples were collected consecutively between January and June 2011 from 486 blood donors living in Jiangsu Province, East China. Anti-HEV IgG was tested by ELISA. RESULTS: One hundred and thirteen blood donors developed HEV IgG antibody, indicating the prevalence of HEV IgG seropositivity to be 23.3%. HEV IgG seropositivity was 25.3% (90/356) in the male group, significantly higher than that in the female group (17.7%, 23/130) (p<0.05). The donors who had donated more than 10 times had significantly higher HEV IgG seropositivity than the other groups (p<0.05). Furthermore, donors aged 50-55 years had significantly higher HEV IgG seropositivity than the other age groups (p<0.05). CONCLUSIONS: We investigated HEV seroprevalence among blood donors in East China. Our data will help identify the risk factors for HEV infection and provide guidance on controlling the safety of blood transfusions in the clinical setting.