[Effect of the intercellular adhesion molecule E-cadherin on the prognosis of non-small cell lung cancer].

The effect of E-cadherin on the prognosis of Stage I-II non-small cell lung cancer (NSCLC) was investigated. Tumor E-cadherin expression and its correlation with the clinical and morphological characteristics of a patient, as well as the prognostic role of this marker were studied. It was ascertained that the E-cadherin expression did not depend on patient gender and age, tumor histological pattern, location, grade, and pT category, but it was significantly related to the pN1 category (p < 0.0001). Univariate analysis revealed that the histological pattern of a tumor, nodal status, resection type (lobectomy/pulmonectomy), and E-cadherin expression level were significantly correlated with patient survival. Multivariate analysis showed that the important predictors were tumor histological pattern and resection type (p = 0.01 and p = 0.00004, respectively). A more complete study of the prognostic and predictive role of E-cadherin expression in patients with Stage I-II NSCLC will help identify a prognostically unfavorable group of patients who may be given additional treatment in the postoperative period.

[Surfactant replacement therapy increases life-span of patients with acute respiratory distress syndrome].

The aim of the study is the evaluation of the influence of surfactant replacement therapy on the life-span of patients with acute respiratory distress syndrome (ARDS) in fatal cases. It has been determined, that in patients, were died from ARDS, exogenous surfactant therapy increases life-span from the moment of establishing of diagnosis of syndrome to fatal outcome. The initial functional state of lungs does not influence on life-span of patients with ARDS, but administration of exogenous surfactant is the important predictor of its increase.

[The influence of microvessel density in the tumor on the prognosis in patients with stage I-II non-small cell lung cancer after surgical treatment].

A study of the prognostic role of microvessel density in tumors of patients with stage I-II non-small cell lung cancer (NSCLC) was performed from June 2008 to June 2011. Determination of microvessel density using the marker CD31 was conducted in 114 patients. Microvessel density was significantly correlated with tumor size: so at greater than 3 cm in diameter, the content of microvessels was 68.7 +/- 3.1, with a smaller tumor size--48.6 +/- 4.5. Independent prognostic markers in patients with stage I-II NSCLC after surgery are histological type (HR = 2.97), tumor size (HR = 4.5), and the number of microvessels in tumor (HR = 3.2).

[Clinico-morphological substantations of parenchyma-preserving operations performance in surgery of chronic pancreatitis].

There was presented a comparative analysis of the surgical treatment results of 86 patients, suffering chronic pancreatitis, in whom resection and parenchyma-preserving elaborated operations were done, aimed for pancreatic and biliary ducts hypertension elimination. According to histological and histochemical data obtained, there are uniform changes, localized in pancreatic head, corpus and tail: the extended periductal fibrosis with the immune-cell infiltration foci and periductal connective tissue sheath formation. According to the immunohistochemical data obtained, in a fibrous zone there was obtained a big quantity of activated alpha-SMA-positive collagen producing star-like cells and a significant expression of a type IV collagen. Indications for surgical treatment, using parenchyma-preserving procedures, were substantiated, taking into account morphological and clinical data present. The patients quality of life in a late follow-up period (5 years) after performance of a proposed operative procedure (the main group), according to all scales of international questionnaires MOS SF-36 applied, were trustworthy better (P < 0.05), than after resection procedures (control group).

[Pathologo-anatomical characteristics of hyperosmolar and other comatous conditions]. / Patologoanatomicheskaia kharakteristika giperosmoliarnykh i drugikh komatoznykh sostoianii.

Fifty-four cases of death from hyperosmolar comas were examined pathoanatomically together with the postmortem biochemical analysis of the CSF and blood. Brain of animals with disturbances of the blood and CSF osmolarity was studied electron cytochemically and autoradiographically. It was discovered that the hyperosmolar comas are manifested by excosis and brain collapse. The brain is reduced in volume due to deep cell-extracell dehydration and alteration of the hematoencephalic barrier with the irreversible depression of the neuronal and glial metabolism. In 7 patients dying with the purulent-necrotic changes of vessels resulting from the hyperosmolar effect of verografin used for the carotid angiography, numerous perivascular hemorrhages developed in the brain. Dysequilibrium syndrome in hemodialysis is manifested by an acute brain swelling or by a formation at a later period of symmetrical ischemic-hemorrhagic necrosis in the thalamus and occipital lobes of the large hemispheres.

[Postresuscitation encephalopathy]. / Postreanimatsionnaia éntsefalopatiia.

On the basis of morphological examination of brain from 250 deceased patients who after clinical death showed, during 1-63 days, symptoms of grave anoxic encephalopathy as well as retrospective analysis of clinical biochemical data, and biochemical post-mortem study of the blood and liquor, the main pathological forms of postresuscitation encephalopathy are distinguished. These are as follows: diffuse-focal anoxic lesions of the brain and spinal cord, partial (complete and incomplete) necroses, isolated total brain necrosis, subtotal necrosis of the brain stem and cerebellum. Morphogenesis as well as extra- and intracranial factors enhancing the development of these forms of encephalopathy are described. Developmental stages of necrotic alterations are singled out, attention is drawn to the processes of organization and reparative regeneration of the brain structural elements in the postresuscitation period. The influence of certain grave metabolic and circulatory disorders on the postresuscitation encephalopathy morphology is shown.