Deep learning versus manual morphology-based embryo selection in IVF: a randomized, double-blind noninferiority trial.

To assess the value of deep learning in selecting the optimal embryo for in vitro fertilization, a multicenter, randomized, double-blind, noninferiority parallel-group trial was conducted across 14 in vitro fertilization clinics in Australia and Europe. Women under 42 years of age with at least two early-stage blastocysts on day 5 were randomized to either the control arm, using standard morphological assessment, or the study arm, employing a deep learning algorithm, intelligent Data Analysis Score (iDAScore), for embryo selection. The primary endpoint was a clinical pregnancy rate with a noninferiority margin of 5%. The trial included 1,066 patients (533 in the iDAScore group and 533 in the morphology group). The iDAScore group exhibited a clinical pregnancy rate of 46.5% (248 of 533 patients), compared to 48.2% (257 of 533 patients) in the morphology arm (risk difference -1.7%; 95% confidence interval -7.7, 4.3; P = 0.62). This study was not able to demonstrate noninferiority of deep learning for clinical pregnancy rate when compared to standard morphology and a predefined prioritization scheme. Australian New Zealand Clinical Trials Registry (ANZCTR) registration: 379161 .

Parents who have received 'psycho-prophylaxis training' during pregnancy and their experience of childbirth - An interview study highlighting the experiences of both parents.

Background: The form of parental support during pregnancy is constantly changing due to developments in society. 'Psycho-prophylaxis training' is a form of parental support used in preparation for childbirth. Only a few studies describe the childbirth experience of both the parents.The aim was to interview parents receiving 'psycho-prophylaxis training' during pregnancy and to elucidate their experience of childbirth.Method: A total of 22 open interviews were conducted with 11 expectant mothers and their 11 partners. Analysis of the interviews was performed using the content analysis method.Results: Three categories emerged in the manifest phase. 'To gain security from knowledge and focus on breathing and relaxation', 'The couple's sense of proximity and the team collaboration with the maternity staff' and 'Meeting pain'. Two themes emerged during the latent analysis of which one was," Participation gave a sense of security" and the other was 'Manageability'.Conclusion: Knowledge about childbirth and the ability, by the mother, to use various breathing techniques seemed to help both parents, as it made both of them feel that they were themselves involved in the process.