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1.
PLoS One ; 19(7): e0307318, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38990840

RESUMEN

[This corrects the article DOI: 10.1371/journal.pone.0268175.].

2.
Otolaryngol Head Neck Surg ; 171(3): 841-848, 2024 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-38699944

RESUMEN

OBJECTIVE: This study aimed to assess the correlation between the spontaneous nystagmus (SN) and the subjective visual vertical/horizontal (SVV/SVH) among patients with vestibular neuritis (VN) at the different head positions. STUDY DESIGN: Case-control study. SETTING: Affiliated Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine. METHODS: This study evaluated the SVV/SVH in both healthy subjects and patients with VN. These evaluations were performed in 5 different head positions: upright, 45° tilt to the left, 90° tilt to the left, 45° tilt to the right, and 90° tilt to the right. Additionally, the intensity of SN, as measured by slow-phase velocity, was recorded. RESULTS: In patients with VN, a significant correlation was observed between SN and SVV/SVH in an upright position. The intensity of SN was higher when the head was tilted 90° toward the affected side compared to other positions. The SVV/SVH displayed an ipsiversive shift, when the head was tilted toward both the lesion and unaffected sides, exhibiting a contraversive direction. Furthermore, the changes in position-induced SN were consistent with the displacements of SVV and SVH caused by head tilt. CONCLUSION: The presence of SN in patients with VN was observed to vary across different head position. These variations could potentially be attributed to the diverse activation patterns of the mechanical properties of otolith organs that are induced by head tilts.


Asunto(s)
Nistagmo Patológico , Neuronitis Vestibular , Humanos , Neuronitis Vestibular/fisiopatología , Neuronitis Vestibular/complicaciones , Masculino , Femenino , Estudios de Casos y Controles , Nistagmo Patológico/fisiopatología , Adulto , Persona de Mediana Edad , Gravitación , Anciano
3.
Adv Sci (Weinh) ; 11(21): e2308477, 2024 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-38590138

RESUMEN

Developing non-precious-metal electrocatalysts that can operate with a low overpotential at a high current density for industrial application is challenging. Heterogeneous bimetallic phosphides have attracted much interest. Despite high hydrogen evolution reaction (HER) performance, the ordinary oxygen evolution reaction (OER) performance hinders their practical use. Herein, it is shown that Fe-doping reverses and enlarges the interfacial electrical field at the heterojunction, turning the H intermediate favorable binding sites for HER into O intermediate favorable sites for OER. Specifically, the self-supported heterojunction catalysts on nickel foam (CoP@Ni2P/NF and Fe-CoP@Fe-Ni2P/NF) are readily synthesized. They only require the overpotentials of 266 and 274 mV to drive a large current density of 1000 mA cm-2 (j1000) for HER and OER, respectively. Furthermore, a water splitting cell equipped with these electrodes only requires a voltage of 1.724 V to drive j1000 with excellent durability, demonstrating the potential of industrial application. This work offers new insights on interfacial engineering for heterojunction catalysts.

4.
Small ; 20(35): e2311895, 2024 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-38660823

RESUMEN

The conformation of molecules and materials is crucial in determining their properties and applications. Here, this work explores the reversible transformation between two distinct conformational isomers in metal nanoclusters. This work demonstrates the successful manipulation of a controllable and reversible isomerization of Au18SR14 within an aqueous solution through two distinct methods: ethanol addition and pH adjustment. The initial driver is the alteration of the solution environment, leading to the aggregation of Au18SR14 protected by ligands with smaller steric hindrance. At the atomic level, the folding mode of the unique Au4SR5 staple underpins the observed structural transformation. The reversal of staple conformation leads to color shifting between green and orange-red, and tailors a second emission peak at 725 nm originating from charge transfer from the thiolate to the Au9 core. This work not only deepens the understanding of the surface structure and dual-emission of metal nanoparticles, but also enhances the comprehension of their isomerization.

5.
Colloids Surf B Biointerfaces ; 236: 113795, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38428207

RESUMEN

Overexpression of epidermal growth factor receptor (EGFR) in cancer is a key cause of recurrence of cervical cancer (CC). Although the EGF-EGFR pathway has been studied for decades, preventing tumor growth and recurrence caused by peripheral EGF remains a great challenge. In this work, a strategy is proposed to reduce the stimulation of high concentration EGF on tumor growth by using a thermo-sensitive hydrogel. The hydrogel is a triblock copolymer composed of polyethylene glycol (PEG) and poly (lactide glycolide) (PLGA). Based on the excellent temperature sensitivity, carrier capacity, swelling property and biocompatibility, the hydrogel can absorb the liquid around the tumor by injection and release EGF continuously at low concentration. The inhibitory effect of hydrogel on tumor growth is fully confirmed by an implanted tumor mouse model with human cervical cancer cell lines (HeLa) using triple-immunodeficient NCG mice. Compared with free EGF, the EGF-loaded hydrogel can hardly induce surface plasmon resonance (SPR) response, which proves that hydrogel can effectively weaken cytoskeleton rearrangement and inhibit cell migration by continuously releasing low concentration EGF. In addition, the EGF-loaded hydrogel can reduce cell proliferation by delaying the progress of cell cycle progression. Taken together, the hydrogel can effectively protect tumor microenvironment from the stimulation of high concentration EGF, delay cancer cellular processes and tumor growth, and thus providing an approach for inhibiting tumor recurrence of CC.


Asunto(s)
Poliésteres , Neoplasias del Cuello Uterino , Femenino , Ratones , Humanos , Animales , Neoplasias del Cuello Uterino/tratamiento farmacológico , Factor de Crecimiento Epidérmico , Preparaciones de Acción Retardada , Polietilenglicoles , Hidrogeles/farmacología , Materiales Biocompatibles , Células HeLa , Receptores ErbB , Microambiente Tumoral
6.
Transl Neurosci ; 13(1): 224-235, 2022 Jan 01.
Artículo en Inglés | MEDLINE | ID: mdl-36045698

RESUMEN

Depression has become one of the most crucial public health issues, threatening the quality of life of over 300 million people throughout the world. Nevertheless, the clinical diagnosis of depression is now still hampered by behavioral diagnostic methods. Due to the lack of objective laboratory diagnostic criteria, accurate identification and diagnosis of depression remained elusive. With the rise of computational psychiatry, a growing number of studies have combined resting-state electroencephalography with machine learning (ML) to alleviate diagnosis of depression in recent years. Despite the exciting results, these were worrisome of these studies. As a result, ML prediction models should be continuously improved to better screen and diagnose depression. Finally, this technique would be used for the diagnosis of other psychiatric disorders in the future.

7.
PLoS One ; 17(6): e0268175, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35714153

RESUMEN

Xinjiang is the largest arid and saline agricultural region in China. The common irrigation methods in this area are traditional flood irrigation and drip irrigation. In this study, we investigated the effects of these two irrigation methods on the fungal diversity, community structures, and functions in alfalfa rhizosphere soil as well as the associated environmental factors in northern Tianshan Mountain (Xinjiang, China). Soil enzyme activities (urease and neutral phosphatase) were significantly higher in the drip-irrigated alfalfa rhizosphere soil than in the flood-irrigated alfalfa rhizosphere soil, whereas the fungal alpha diversity in the drip-irrigated alfalfa rhizosphere soil was significantly lower than that in the flood-irrigated alfalfa rhizosphere soil. Six dominant fungal phyla were identified (>0.1%), with Ascomycota being the most abundant in all soils, followed by Basidiomycota (5.47%), Mortierellomycota (1.07%), Glomeromycota (0.55%), Rozellomycota (0.27%), and Chytridiomycota (0.14%). Ascomycota and Glomeromycota species were significantly less abundant in drip-irrigated alfalfa rhizosphere soil than in flood-irrigated alfalfa rhizosphere soil. A LEFSe analysis identified Cladosporiaceae (20.8%) species as the most abundant marker fungi in drip-irrigated alfalfa rhizosphere soil. Of the 13 fungal functional groups identified on the basis of the functional annotation using the FUNGuild database, Ectomycorrhizal (22.29%) was the primary functional group. Compared with flood irrigation, drip irrigation significantly decreased the relative abundance of Ectomycorrhizal and Arbuscular_Mycorrhizal, while increasing the relative abundance of Plant_Pathogen, although not significantly (P = 0.19). Available potassium was revealed to be the main environmental factor influencing soil enzyme activities, fungal alpha diversity, fungal community structures, and fungal functions in response to the different irrigation methods. In conclusion, drip irrigation may be more appropriate than flood irrigation in the Tianshan dryland agricultural area for enhancing soil enzyme activities, but it may also increase the abundance of plant pathogenic fungi in the soil.


Asunto(s)
Ascomicetos , Micobioma , Medicago sativa , Rizosfera , Suelo/química , Microbiología del Suelo
8.
Front Microbiol ; 13: 1086058, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-36605506

RESUMEN

To contribute to the conservation of endangered animals, the utilization of model systems is critical to analyze the function of their gut microbiota. In this study, the results of a fecal microbial transplantation (FMT) experiment with germ-free (GF) mice receiving giant panda or horse fecal microbiota showed a clear clustering by donor microbial communities in GF mice, which was consistent with the results of blood metabolites from these mice. At the genus level, FMT re-established approximately 9% of the giant panda donor microbiota in GF mice compared to about 32% for the horse donor microbiota. In line with this, the difference between the panda donor microbiota and panda-mice microbiota on whole-community level was significantly larger than that between the horse donor microbiota and the horse-mice microbiota. These results were consistent with source tracking analysis that found a significantly higher retention rate of the horse donor microbiota (30.9%) than the giant panda donor microbiota (4.0%) in GF mice where the microbiota remained stable after FMT. Further analyzes indicated that the possible reason for the low retention rate of the panda donor microbiota in GF mice was a low relative abundance of Clostridiaceae in the panda donor microbiota. Our results indicate that the donor microbiota has a large effect on GF mice microbiota after FMT.

9.
Anticancer Drugs ; 33(1): e198-e206, 2022 01 01.
Artículo en Inglés | MEDLINE | ID: mdl-34387592

RESUMEN

Growing evidence has shown that aerobic glycolysis, as a hallmark of cancer cells, plays a crucial role in cervical cancer. The aim of the study is to uncover whether fructose-1,6-bisphosphatase 2 (FBP2) is involved in cervical cancer progression via the aerobic glycolysis pathway. FBP2 levels were determined by quantitative PCR (qPCR) and western blotting. Cell growth viability and apoptosis were tested by cell counting kit-8 (CCK-8) and flow cytometry assays. Immunoprecipitation assay was applied for the detection of the FBP2 effect on pyruvate kinase isozyme type M2 (PKM2) ubiquitination. FBP2 level was decreased in cervical cancer, which is closely linked to shorter overall survival. FBP2 decreased cell growth and aerobic glycolysis and increased cell apoptosis, as well as decreased PKM2 expression and increased its ubiquitination level. The above-mentioned roles of FBP2 were weakened followed by PKM2 overexpression. FBP2 inhibited cervical cancer cell growth via inhibiting aerobic glycolysis by inducing PKM2 ubiquitination.


Asunto(s)
Fructosa-Bifosfatasa/genética , Piruvato Quinasa/genética , Neoplasias del Cuello Uterino/genética , Neoplasias del Cuello Uterino/patología , Efecto Warburg en Oncología , Apoptosis/fisiología , Línea Celular Tumoral , Femenino , Regulación Neoplásica de la Expresión Génica/fisiología , Humanos , Estadificación de Neoplasias , Ubiquitinación/fisiología
10.
Altern Ther Health Med ; 28(2): 89-95, 2022 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-34936992

RESUMEN

OBJECTIVE: This study aimed to assess whether a 5-year follow-up education intervention changed the risk for fragility fractures and increased bone mineral density (BMD) in elderly women with osteoporosis. METHODS: This randomized controlled trial included 104 women who were hospitalized or visited a specialist for osteoporosis care at Sichuan Translational Medicine Research Hospital in China from October 2013 to June 2014. The patients were randomly assigned to either an education intervention group (n = 52) or a control group (n = 52). The intervention was conducted by an endocrinologist who provided the intervention group with personized recommendations. All participants were followed for 5 years. RESULTS: Compared with the control group, the patients in the intervention group had a lower risk for fragility fracture, lower pain score, higher BMD at the greater trochanter of the femur, total hip and the first lumbar vertebra, together with higher compliance with anti-osteoporosis drug regimens and higher intake of vitamin D supplements (all P <.05). After adjustment for history of fracture, calcium consumption, age and body mass index (BMI), the association of change in BMD and pain score and the medication possession ratio (MPR) of anti-osteoporosis drugs were both significantly different (P < .05, P < .001, respectively). In subgroup analysis by past fractures, patients who experienced post-fractures were more likely to experience refracture (P < .05). CONCLUSIONS: The personalized education intervention by endocrinologists can significantly increase the BMD of the greater trochanter of the femur and reduce pain scores in elderly women with osteoporosis, suggesting that this education intervention may serve as an important addition to standard anti-osteoporosis treatment.


Asunto(s)
Conservadores de la Densidad Ósea , Osteoporosis Posmenopáusica , Osteoporosis , Fracturas Osteoporóticas , Anciano , Densidad Ósea , Suplementos Dietéticos , Femenino , Humanos , Osteoporosis Posmenopáusica/tratamiento farmacológico , Fracturas Osteoporóticas/prevención & control
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