RESUMEN
Improving the load adjustment rate of coal-fired power plants in China is very important because of grid load fluctuations and the construction of new large-scale power plants connected to the country's power grid. In this paper, a new application of condensate throttling system for rapid load adjustment is proposed on the basis of the characteristics of turbine-stored energy. To ensure effective and safe operation of the condensate throttling system, a non-linear control model is derived through reasonable simplifications of fundamental physical laws, and the model parameters are identified using experimental data from a 660 MW supercritical coal-fired power plant. The model outputs are compared with actual measured data for different unit loads. Results show that the established model's responses strongly correlate with the actual unit's responses and can be used for controller design.
RESUMEN
Type 1 diabetes mellitus (T1DM) is associated with a series of bone complications, which are still a great challenge in the clinic. Bone marrow stromal cells (BMSCs) are crucial to bone remodeling and are attractive candidates for tissue engineering. Hence, we aimed to investigate whether impaired functions of BMSCs play a role in the pathogenesis of bone complications associated with T1DM. BMSCs were isolated from normal and streptozotocin-induced diabetic rats, and their proliferation and osteogenic differentiation ability were analyzed. Diabetic BMSCs demonstrated reduced proliferation ability, osteoblast gene expression, alkaline phosphatase activity and mineralization. Nude mice transplanted with diabetic BMSCs in a calcium phosphate cement scaffold exhibited reduced new bone formation, as detected by hematoxylin and eosin staining and immunohistochemistry. These changes may be partially related to impaired insulin and insulin-like growth factor 1 (IGF-1) signaling. Weak gene expression of insulin receptor (IR), IGF-1, insulin-like growth factor 1 receptor (IGF-1R), and insulin receptor substrate-1 (IRS-1) was observed in the diabetic BMSCs compared with normal BMSCs, together with decreased protein level of IGF-1, IGF-1R, IRS-1 and phosphorylated extracellular signal-regulated kinase. Therefore, impaired proliferation and osteogenic potential of BMSCs may be responsible for bone complications related to T1DM, mediated partially by impaired insulin and IGF-1 signaling. These findings may provide a new target with which to devise strategies for therapy.