RESUMEN
PURPOSE: The objectives were to transplant a venous valve into the popliteal vein of a canine insufficiency model that would maintain long-term function and then to measure the hemodynamic benefit of such a valve. METHODS: Indexes of venous valvular function, including venous filling time, 90% of venous refilling time, and simulated ambulatory venous pressure, were measured in 11 greyhounds before intervention (Control) and after hind limb venous valvulotomy, which produces chronic venous insufficiency. Three weeks later a valve-containing segment of external jugular vein was transplanted to the popliteal vein with (n = 6) or without (n = 5) a distal arteriovenous fistula. The fistula was ligated in 4 to 6 weeks. Repeat venous indexes were obtained an average of 2 weeks after the last operative intervention. Gross anatomic inspection +/- duplex scanning performed before the animals were killed were used to distinguished normal from damaged valves. RESULTS: Four of five simple valve transplants demonstrated scarring and/or thrombosis and the average venous filling time, ambulatory venous pressure, and 90% of venous refilling time were consistent with chronic venous insufficiency and/or obstruction. One fistula failed in the six valve distal arteriovenous fistula transplants, and that valve was incompetent. Analysis of the remaining five functional valves demonstrated venous filling time consistent with chronic venous insufficiency, normalization of ambulatory venous pressure, and 90% of venous refilling time between normal, and chronic venous insufficiency. These valves appeared normal. CONCLUSIONS: Popliteal vein valve transplant anatomy is preserved by an adjunctive distal arteriovenous fistula, and a competent valve transplant improves postexercise venous hemodynamics to approach those of a normal limb.
Asunto(s)
Derivación Arteriovenosa Quirúrgica , Venas Yugulares/trasplante , Vena Poplítea/cirugía , Insuficiencia Venosa/cirugía , Análisis de Varianza , Animales , Enfermedad Crónica , Perros , Estudios de Seguimiento , Oclusión de Injerto Vascular/epidemiología , Ligadura , Modelos Biológicos , Vena Poplítea/fisiopatología , Flujo Sanguíneo Regional , Factores de Tiempo , Resultado del Tratamiento , Insuficiencia Venosa/fisiopatología , Presión VenosaRESUMEN
Continued study of a chronic deep venous insufficiency (CDVI) model allows optimal comparison with the human condition. This study evaluates the model's long-term stability, its lack of observed clinical effect, and a simulated exercise study as a physiologic estimate of normal hindlimb walking. The time to maximal ankle venous pressure after standing (VFT), and to 90% of the venous refilling time after electrical stimulation, quadripedal, or hindlimb walking (VRT90), and the minimal pressure after exercise (AVP) were measured up to 10 months after CDVI model creation. The animals' intravenous resting pressure was obtained after standing stationary on all four limbs. Analysis of variance was used to determine statistical significance where indicated. VFT, AVP, and VRT90 measurements demonstrated values consistent with CDVI in animals studied up to 10 months after model creation and were statistically different from control limb values (p < or = .002, n = 8). Animals studied during quadripedal walking showed no difference in resting pressure, AVP, and VRT90 between model and control limbs (n = 5). There was no statistical difference in AVP or VRT90 measured under conditions of stimulated exercise or bipedal walking; and both conditions produced hemodynamic changes consistent with CDVI (n = 5). This animal model is a reliable long-term CDVI hemodynamic model. The normal venous hemodynamics recorded during quadripedic walking may explain the lack of clinical sequelae observed in this model. Lastly, the method of simulated exercise used in this study is a reliable test that reflects physiologic measurements obtained during bipedal walking.
Asunto(s)
Modelos Animales de Enfermedad , Insuficiencia Venosa/fisiopatología , Animales , Enfermedad Crónica , Perros , Estimulación Eléctrica , Condicionamiento Físico Animal/fisiología , Insuficiencia Venosa/terapia , Caminata/fisiologíaRESUMEN
A total of 149 consecutive unselected patients (221 limbs) who presented with signs and symptoms of chronic venous problems (varicose veins with or without ankle oedema, skin changes and leg ulcers) have been studied by clinical examination, ascending deep to superficial venography, Doppler ultrasound and ambulatory venous pressure measurements. Of the limbs, 180 (82 per cent) had varicose veins without obstruction in the deep veins or reflux in the popliteal or femoral veins while 41 (18 per cent) had deep venous disease. Of the 180 limbs with 'primary' varicose veins 110 (60 per cent) did not have incompetent calf perforating veins (group A) while 70 (40 per cent) did (group B). On the basis of the ambulatory venous pressure after calf muscle exercise and the refilling time, the incompetent calf perforating veins of limbs in group B belonged to three subgroups of different haemodynamic significance. In 20 limbs (30 per cent) they were found to be of no haemodynamic significance, in 25 (35 per cent) of moderate haemodynamic significance and in 25 (35 per cent) of major haemodynamic significance. The last were, on clinical examination, indistinguishable from limbs with deep venous disease although they had patent deep veins with competent popliteal valves.
Asunto(s)
Pierna/irrigación sanguínea , Várices/fisiopatología , Insuficiencia Venosa/fisiopatología , Humanos , Flebografía , Vena Poplítea/diagnóstico por imagen , Vena Safena/diagnóstico por imagen , Ultrasonografía , Várices/complicaciones , Várices/diagnóstico por imagen , Insuficiencia Venosa/complicaciones , Insuficiencia Venosa/diagnóstico por imagen , Presión VenosaRESUMEN
The management of asymptomatic carotid stenosis remains controversial. From December 1983 to December 1987, 188 symptom-free patients were found to have severe (greater than 75%) stenosis by duplex imaging (performed as screening examination). Patients with non-hemispheric symptoms or contralateral symptomatic lesions (within 7 years) were excluded from the study. Follow-up data were available for 141 patients (range 3 to 36 months; mean 21 months). Sixty-two patients received nonoperative therapy. The remaining 79 patients underwent 100 carotid endarterectomies (CAE) (21 staged bilateral repairs and 58 unilateral repairs). There were no statistically significant differences in sex, age, or risk factors (i.e., hypertension, diabetes, or smoking) or in the incidence of bilateral disease. Significant differences were found in the incidence of ischemic attacks (0 vs 21%; p less than 0.001) and stroke (2.5% vs 18%; p less than 0.01) in the operative vs nonoperative group. None of the 11 strokes in the nonoperative group were preceded by neurologic events. The operative group had an overall stroke rate of 2.5% (2/79), a perioperative mortality rate of 1.3% (1/79), and a restenosis (greater than 50%) rate of 3.8% (3/79). Thus favorable results can be achieved with prophylactic CAE. These data support the use of prophylactic CAE in any patient with greater than 75% stenosis identified by duplex image, regardless of sex, age, risk factors, or bilateral disease.
Asunto(s)
Arteriopatías Oclusivas/terapia , Enfermedades de las Arterias Carótidas/terapia , Anciano , Arteriopatías Oclusivas/diagnóstico , Arteriopatías Oclusivas/cirugía , Enfermedades de las Arterias Carótidas/diagnóstico , Enfermedades de las Arterias Carótidas/cirugía , Trastornos Cerebrovasculares/etiología , Endarterectomía , Femenino , Estudios de Seguimiento , Humanos , Ataque Isquémico Transitorio/etiología , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , UltrasonografíaAsunto(s)
Presión Venosa , Femenino , Humanos , Pierna/irrigación sanguínea , Masculino , Vena Poplítea/fisiologíaRESUMEN
A noninvasive method to evaluate deep venous incompetence by duplex scanning is presented. For this test, it was decided to have the patient standing so as to make the test less dependent on the need for patient cooperation and to allow gravity to produce reflux. Results were validated against ambulatory venous pressure measurements. The method described had a sensitivity of 84% and specificity of 88%. Duplex scanning is a useful screening test for detecting the presence and site of incompetence in patients with deep venous disease.
Asunto(s)
Ultrasonografía/métodos , Insuficiencia Venosa/diagnóstico , Humanos , Pierna/irrigación sanguínea , Flebografía , Esfuerzo Físico , Pletismografía , Flujo Sanguíneo Regional , Insuficiencia Venosa/fisiopatología , Presión VenosaRESUMEN
The purpose of the study was to determine the association between cerebral infarction seen on CT scan and macroscopic ulceration of atheromatous carotid plaques in patients undergoing carotid endarterectomy. Following carotid endarterectomy in 65 patients, specimens were examined for the presence of ulceration without knowing the result of the preoperative CT brain scan. The 65 patients thus investigated underwent 68 carotid endarterectomies: 36 for a history of transient ischemic attacks (TIAs), 13 for amaurosis fugax, and six for prior strokes; 13 asymptomatic patients had prophylactic carotid endarterectomy prior to coronary bypass. A macroscopic ulcer was present in 42 specimens. Twenty-six (62%) of the patients with ulceration had one or more ipsilateral cerebral infarcts on CT scan. Only two (8%) of the 26 patients without an ulcer had cerebral infarcts. Of the 36 patients who presented with TIAs, 26 (72%) had carotid plaque ulcers and 23 (88%) of these had cerebral infarcts on CT scan also. In contrast, only three of 13 asymptomatic patients had plaque ulcers and only one of these had a cerebral infarct. There is a high incidence of cerebral infarction seen on CT scan in patients presenting with TIAs. These infarcts occur predominantly in patients with ulcerated atheromatous carotid lesions.