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1.
Sensors (Basel) ; 24(19)2024 Sep 29.
Artículo en Inglés | MEDLINE | ID: mdl-39409357

RESUMEN

Satellite-borne electromagnetic pulse (EMP) detection technology plays an important role in military reconnaissance, space environment monitoring, and early warning of natural disasters. However, the complex ionosphere greatly distorts the waveform during propagation and poses a challenge to EMP detection. Therefore, it is necessary to conduct theoretical research on EMP propagation in the ionosphere. Conventional second-order pseudo-spectral time-domain (PSTD-2) algorithm has difficulties in keeping the stability and accuracy of waveforms in calculations over hundreds of kilometers of propagation. To overcome the difficulties, a fourth-order PSTD algorithm incorporating the moving window technique (MWPSTD-4) is proposed. In the numerical examples, the performance of MWPSTD-4 is compared with PSTD-4 and PSTD-2 in the long-distance propagation of EMP. The results show that the MWPSTD-4 improves efficiency while guaranteeing accuracy and is suitable for large-scale electromagnetic field simulation. The proposed method provides a basic algorithm to eliminate the numerical dispersion interference for calculating the long-distance propagation of EMP in complex spaces and is helpful for the design and calibration of satellite-borne EMP detectors.

2.
Sensors (Basel) ; 24(19)2024 Oct 02.
Artículo en Inglés | MEDLINE | ID: mdl-39409446

RESUMEN

The Spaceborne Global Lightning Location Network (SGLLN) serves the purpose of identifying transient lightning events occurring beneath the ionosphere, playing a significant role in detecting and warning of disaster weather events. To ensure the effective functioning of the wideband electromagnetic pulse detector, which is a crucial component of the SGLLN, it must be tested and verified with specific signals. However, the inherent randomness and unpredictability of lightning occurrences pose challenges to this requirement. Consequently, a high-power electromagnetic pulse radiation system with a 20 m aperture reflector is designed. This system is capable of emitting nanosecond electromagnetic pulse signals under pre-set spatial and temporal conditions, providing a controlled environment for assessing the detection capabilities of SGLLN. In the design phase, an exponentially TEM feed antenna has been designed firstly based on the principle of high-gain radiation. The feed antenna adopts a pulser-integrated design to mitigate insulation risks, and it is equipped with an asymmetric protective loading to reduce reflected energy by 85.7%. Moreover, an innovative assessment method for gain loss, based on the principle of Love's equivalence, is proposed to quantify the impact of feed antenna on the radiation field. During the experimental phase, a specialized E-field sensor is used in the far-field experiment at a distance of 400 m. The measurements indicate that at this distance, the signal has a peak field strength of 2.2 kV/m, a rise time of 1.9 ns, and a pulse half-width of 2.5 ns. Additionally, the beamwidth in the time domain is less than 10°. At an altitude of 500 km, the spaceborne detector records a signal with a peak field strength of approximately 10 mV/m. Particularly, this signal transformed into a nonlinear frequency-modulated signal in the microsecond range across its frequency spectrum, which is consistent with the law of radio wave propagation in the ionosphere. This study offers a stable and robust radiation source for verifying spaceborne detectors and establishes an empirical foundation for investigating the impact of the ionosphere on signal propagation characteristics.

3.
Materials (Basel) ; 17(15)2024 Aug 04.
Artículo en Inglés | MEDLINE | ID: mdl-39124527

RESUMEN

Collision welding is a promising approach for joining conventional materials in identical or dissimilar combinations without heat-related strength loss, thereby opening up new lightweight potential. Widespread application of this technology is still limited by an insufficient state of knowledge with respect to the underlying joining mechanisms. This paper applies collision welding to a material combination of DC04 steel and EN AW 6016 aluminium alloy. Firstly, the welding process window for the combination is determined by varying the collision speed and the collision angle, the two main influencing variables in collision welding, using a special model test rig. The process window area with the highest shear tensile strength of the welded joint is then determined using shear tensile tests and SEM images of the weld zone. The SEM investigations reveal four distinct metallographic structures in the weld zones, the area fractions of which are determined and correlated with collision angle and shear tensile strength.

4.
Materials (Basel) ; 17(12)2024 Jun 12.
Artículo en Inglés | MEDLINE | ID: mdl-38930232

RESUMEN

The term electromagnetic pulse (EMP) generally refers to high-power electromagnetic waves and can be classified into EMPs caused by nuclear weapons, non-nuclear EMPs, and EMPs caused by natural phenomena. EMPs can cause catastrophic damage to any electronic device consisting of electromagnetic components, including communications devices and transportation. In this study, the shielding effectiveness of paint was evaluated depending on the type and content of carbon material and binder. To analyze the compatibility and dispersibility improvement of the raw materials used in paint manufacturing, experiments were conducted in two stages, using 27 mixtures. The shielding effectiveness was evaluated for the optimal mixture developed through mixture experiments. The results of this study confirmed that the developed EMP shielding paint can improve the shielding effectiveness of concrete by 25-40 dB. Additionally, the adhesion strength and moisture resistance evaluation of the EMP shielding paint were evaluated. The average adhesive strength of the EMP shielding paint was 1.26 MPa. In moisture-resistance testing at a temperature of 50 ± 3 °C and a relative humidity of 95% or higher for more than 120 h, no cracks or peeling were observed on the painted surface.

5.
Bioelectromagnetics ; 45(3): 130-138, 2024 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-38105659

RESUMEN

The blood-brain barrier (BBB) is the main obstacle to hydrophilic and large molecules to enter the brain, maintaining the stability of the central nervous system (CNS). But many environmental factors may affect the permeability and structure of the BBB. Electromagnetic pulses (EMP) irradiation has been proven to enhance the permeability of the BBB, but the specific mechanism is still unclear. To explore the potential mechanism of EMP-induced BBB opening, this study investigated the permeability, fine structure and the proteins expression of the tight junction (TJ) of the BBB in the rats exposed to EMP. Using the leakage of fluorescein isothiocyanate-labeled dextran with different molecular mass under different field intensity of EMP exposure, we found that the tracer passing through the BBB is size-dependent in the rat exposed to EMP as field intensity increased. Transmission electron microscopy showed TJ of the endothelial cells in the EMP-exposed group was open, compared with the sham-irradiated group. But the levels of TJ proteins including ZO-1, claudin-5, or occludin were not changed as indicated by western blot. These data suggest that EMP induce BBB opening in a field intensity-dependent manner and probably through dysfunction of TJ proteins instead of their expression. Our findings increase the understanding of the mechanism for EMP working on the brain and are helpful for CNS protection against EMP.


Asunto(s)
Barrera Hematoencefálica , Uniones Estrechas , Ratas , Animales , Barrera Hematoencefálica/metabolismo , Ratas Sprague-Dawley , Uniones Estrechas/metabolismo , Células Endoteliales/metabolismo , Ocludina/metabolismo , Campos Electromagnéticos/efectos adversos
6.
Sensors (Basel) ; 23(17)2023 Aug 23.
Artículo en Inglés | MEDLINE | ID: mdl-37687812

RESUMEN

The transient surface current density reflects the external coupling of the electromagnetic pulse (EMP) to the tested device. In this paper, the generation mechanism and measurement principle of conductor surface current density are introduced, and the surface current density distribution irradiated by EMP on a typical aircraft structure is simulated and analyzed. The traditional surface current density is usually measured by B-dot antenna, but its output signal is the differential of the measured signal, so additional integrators or numerical integration of the measured data are required. In this paper, a self-integrating surface current sensor based on optical fiber transmission is designed based on the shielded loop antenna with gap structure. The output signal is the real signal waveform to be measured. Compared with coaxial cables, integrated optical fiber transmission improves the anti-interference ability of long-distance transmission signals. At the same time, the design process of the sensor is introduced in detail. The bandwidth of the sensor is 300 kHz~500 MHz, the sensitivity is calibrated at 1.23 (A·m-1)/mV, and the dynamic range is ±25~1400 A·m-1 (35 dB). The surface current of a metal plate is measured in a bounded wave electromagnetic pulse simulator using a detector developed in this paper. The test results show that the developed sensor has good engineering applicability.

7.
Environ Sci Pollut Res Int ; 30(35): 83717-83727, 2023 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-37349489

RESUMEN

Microwave (MW) and electromagnetic pulse (EMP) are considered environmental pollutants, both of which can induce learning and memory impairments. However, the bioeffects of combined exposure to MW and EMP have never been explored. This paper aimed to investigate the effects of combined exposure to MW and EMP on the learning and memory of rats as well as its association with ferroptosis in the hippocampus. In this study, rats were exposed to EMP, MW, or EMP and MW combined radiation. After exposure, impairment of learning and memory, alterations in brain electrophysiological activity, and damage to hippocampal neurons were observed in rats. Moreover, we also found alterations in ferroptosis hallmarks, including increased levels of iron, lipid peroxidation, and prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA, as well as downregulation of glutathione peroxidase 4 (GPX4) protein in the rat hippocampus after exposure. Our results suggested that either single or combined exposure to MW and EMP radiation could impair learning and memory and damage hippocampal neurons in rats. Moreover, the adverse effects caused by the combined exposure were more severe than the single exposures, which might be due to cumulative effects rather than synergistic effects. Furthermore, ferroptosis in the hippocampus might be a common underlying mechanism of learning and memory impairment induced by both single and combined MW and EMP exposure.


Asunto(s)
Ferroptosis , Ratas , Animales , Microondas/efectos adversos , Aprendizaje/efectos de la radiación , Hipocampo , Trastornos de la Memoria
8.
Int J Mol Sci ; 24(8)2023 Apr 14.
Artículo en Inglés | MEDLINE | ID: mdl-37108409

RESUMEN

The effect of nanosecond electromagnetic pulses on human health, and especially on forming free radicals in human cells, is the subject of continuous research and ongoing discussion. This work presents a preliminary study on the effect of a single high-energy electromagnetic pulse on morphology, viability, and free radical generation in human mesenchymal stem cells (hMSC). The cells were exposed to a single electromagnetic pulse with an electric field magnitude of ~1 MV/m and a pulse duration of ~120 ns generated from a 600 kV Marx generator. The cell viability and morphology at 2 h and 24 h after exposure were examined using confocal fluorescent microscopy and scanning electron microscopy (SEM), respectively. The number of free radicals was investigated with electron paramagnetic resonance (EPR). The microscopic observations and EPR measurements showed that the exposure to the high-energy electromagnetic pulse influenced neither the number of free radicals generated nor the morphology of hMSC in vitro compared to control samples.


Asunto(s)
Fenómenos Electromagnéticos , Células Madre Mesenquimatosas , Humanos , Radicales Libres , Factores Inmunológicos
9.
Mol Brain ; 16(1): 21, 2023 02 07.
Artículo en Inglés | MEDLINE | ID: mdl-36750928

RESUMEN

Electromagnetic pulse (EMP), a unique type of electromagnetic radiation, may induce diverse neuropsychiatric disorders, such as irritability, hyperkinesis, retardation of learning and memory. However, the underlying mechanism of EMP exposure on neuronal injury has not been elucidated. Here, we aimed to delineate the regulatory expression networks based on high-throughput sequencing data to explore the possible molecular mechanisms related to EMP-induced delirium-like neuropsychiatric disorder in rats. It's shown that EMP exposure induced anxiety, cognitive decline and short-term memory impairment. The expression profiles of the long noncoding RNAs (lncRNAs) and mRNAs, along with their biological function and regulatory network, were explored in rats after EMP exposure. We identified 41 differentially expressed lncRNAs (DELs) and 266 differentially expressed mRNAs (DEMs) between EMP and sham groups. Sixty-one co-expression relationships between 18 DELs and 56 DEMs were mostly associated with synapse- and metabolic-related pathways. We predicted 51 DEL-miRNA pairs and 290 miRNA-mRNA pairs using the miRanda database to constructed a DEL-miRNA-DEM network. LncRNA AABR07042999.1 and mRNA Tph2, Slc6a4, Dbh and Th were upregulated, and the contents of serotonin, dopamine and norepinephrine were increased in both PFC and HIP after EMP exposure. The current study provided a better understanding of the ceRNA network, which might reveal the pathological mechanism and provide more treatment options for the EMP-induced neurobehavioral disorder.


Asunto(s)
Delirio , MicroARNs , ARN Largo no Codificante , Ratas , Animales , ARN Largo no Codificante/genética , Redes Reguladoras de Genes , MicroARNs/genética , Fenómenos Electromagnéticos , ARN Mensajero/genética , Biología Computacional
10.
Materials (Basel) ; 16(4)2023 Feb 06.
Artículo en Inglés | MEDLINE | ID: mdl-36837002

RESUMEN

The surface treatment of concrete enhances the bonding of its metal coatings. Therefore, in the present study, on the concrete surface, prior to the deposit of an 85Zn-15Al coating via an arc thermal spraying process, different surface treatments were considered for the effective electromagnetic pulse (EMP) shielding properties of the concrete. However, the direct coating on a concrete surface possesses lower bond adhesion, therefore it is of the utmost importance to treat the concrete surface prior to the deposition of the metal coating. Moreover, to obtain better bond adhesion and fill the defects of the coating, the concrete surface is treated by applying a surface hardener (SH), as well as a surface roughening agent (SRA) and a sealing agent (SA), respectively. The metal spraying efficiency, adhesion performance, and bonding strength under different concrete surface treatment conditions were evaluated. The EMP shielding effect was evaluated under the optimal surface treatment condition. The proposed method for EMP shielding exhibited over 60% of spraying efficiency on the treated surface and a bonding strength of up to 3.9 MPa for the SH-SRA-SA (combining surface roughening and pores/defects filling agents) specimen compared to the control one, i.e., 0.8 MPa. The EMP shielding values of the surface-treated concrete with surface hardener, surface roughening agent, and sealing agent, i.e., SH-SRA-SA specimens, exhibited 96.6 dB at 1000 MHz. This was about 12 times higher than without coated concrete.

11.
Front Public Health ; 11: 1103022, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36817910

RESUMEN

Background: Excessive doses of electromagnetic radiation pose a negative impact on the central nervous system and lead to mental disorders. Molecular hydrogen can scavenge intracellular hydroxyl radicals, acting as an antioxidant, anti-apoptotic and anti-inflammatory agent. We seek to assess the capability of molecular hydrogen to ameliorate brain damage induced by electromagnetic radiation. Methods: NEMP (nuclear electromagnetic pulse), a subset of electromagnetic pulse with high voltage value that could cause severe brain injury, was applied to this study. Male wild-type rats were divided into four groups: the control group, the H2 (Molecular hydrogen) group, the NEMP group and the NEMP+H2 group. Rats in the H2 group and the NEMP+H2 group were fed with saturated hydrogen-rich water from 3 days before NEMP exposure (electromagnetic field intensity 400 kV/m, rising edge 20 ns and pulse width 200 ns) to the day of sacrifice. One day after exposure, animal behavior experiments were performed, and samples for transcriptomics and metabolomics analysis were collected. Seven days after exposure, histopathological experiments were conducted. Results: The data from the elevated plus maze and the open field test showed that NEMP exposure elicited anxiety-like behavior in rats, which could be alleviated by H2 treatment. Histopathological results manifested that NEMP exposure-induced injuries of the neurons in the hippocampus and amygdala could be attenuated by H2 treatment. Transcriptomic results revealed that NEMP exposure had a profound effect on microtubule structure in the brain. And the combined analysis of transcriptomics and metabolomics showed that H2 has a significant impact on the neuroactive ligand-receptor interaction, synaptic vesicle cycle and synapse etc. Moreover, it was indicated that the glutathione metabolic pathway played a vital role in the NEMP exposure-induced damage and the protective activity of H2. Conclusions: H2 is identified as a potent agent against NEMP exposure-induced brain damage and has the potential to be a promising electromagnetic radiation protectant.


Asunto(s)
Lesiones Encefálicas , Transcriptoma , Ratas , Masculino , Animales , Estrés Oxidativo , Fenómenos Electromagnéticos , Hidrógeno/química , Hidrógeno/farmacología , Encéfalo
12.
Sensors (Basel) ; 22(21)2022 Nov 06.
Artículo en Inglés | MEDLINE | ID: mdl-36366236

RESUMEN

The measurement of the transient pulsed electromagnetic (EM) field is essential for analyzing electromagnetic compatibility. Due to their good performance, D-dot sensors, combined with numerical integration computation for signal recovery, are commonly used to measure electromagnetic pulses (EMPs). However, the integration approach is occasionally flawed due to a non-ideal frequency response or noise, causing distortions in the reconstructed signal. In order to better understand the dynamic performance of the sensor, a nonlinear Hammerstein model is employed in the system identification for the sensor with the calibration data collected in the laboratory environment. When identifying the linear component based on the ultra-wideband characteristics of the measured transient pulse, a two-step identification approach with two different pulse excitation modes, low frequency and high frequency, is utilized to conduct the modeling across the entire frequency range. Based on the reliable identification and modeling of the D-dot sensor, a compensation system that corresponds to the nonlinear Hammerstein model has been developed for the practical signal recovery of the incident E-field. After compensation, the dynamic characteristics of the sensor are significantly improved, and the system compensation approach outperforms the integration method in signal recovery for the incident E-field.

13.
Front Cell Neurosci ; 16: 898164, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35966202

RESUMEN

Electromagnetic pulse (EMP) is a high-energy pulse with an extremely rapid rise time and a broad bandwidth. The brain is a target organ sensitive to electromagnetic radiation (EMR), the biological effects and related mechanisms of EMPs on the brain remain unclear. The objectives of the study were to assess the effects of EMP exposure on mouse cognitions, and the neuronal calcium activities in vivo under different cases of real-time exposure and post exposure. EMP-treated animal model was established by exposing male adult C57BL/6N mice to 300 kV/m EMPs. First, the effects of EMPs on the cognitions, including the spatial learning and memory, avoidance learning and memory, novelty-seeking behavior, and anxiety, were assessed by multiple behavioral experiments. Then, the changes in the neuronal activities of the hippocampal CA1 area in vivo were detected by fiber photometry in both cases of during real-time EMP radiation and post-exposure. Finally, the structures of neurons in hippocampi were observed by optical microscope and transmission electron microscope. We found that EMPs under this condition caused a decline in the spatial learning and memory ability in mice, but no effects on the avoidance learning and memory, novelty-seeking behavior, and anxiety. The neuron activities of hippocampal CA1 were disturbed by EMP exposure, which were inhibited during EMP exposure, but activated immediately after exposure end. Additionally, the CA1 neuron activities, when mice entered the central area in an Open field (OF) test or explored the novelty in a Novel object exploration (NOE) test, were inhibited on day 1 and day 7 after radiation. Besides, damaged structures in hippocampal neurons were observed after EMP radiation. In conclusion, EMP radiation impaired the spatial learning and memory ability and disturbed the neuronal activities in hippocampal CA1 in mice.

14.
Int J Mol Sci ; 23(16)2022 Aug 17.
Artículo en Inglés | MEDLINE | ID: mdl-36012537

RESUMEN

Electromagnetic pulse (EMP) radiation was reported to be harmful to hippocampal neurons. However, the mechanism underlying EMP-induced neuronal damage remains unclear. In this paper, for the first time, we attempted to investigate the involvement of ferroptosis in EMP-induced neuronal damage and its underlying mechanism. In vivo studies were conducted with a rat model to examine the association of ferroptosis and EMP-induced hippocampal neuronal damage. Moreover, in vitro studies were conducted with HT22 neurons to investigate the underlying mechanism of EMP-induced neuronal ferroptosis. In vivo results showed that EMP could induce learning and memory impairment of rats, ferroptotic morphological damages to mitochondria, accumulation of malonaldehyde (MDA) and iron, overexpression of prostaglandin-endoperoxide synthase 2 (PTGS2) mRNA, and downregulation of GPX4 protein in rat hippocampus. In vitro results showed that EMP could induce neuronal death, MDA accumulation, iron overload, PTGS2 overexpression, and GPX4 downregulation in HT22 neurons. These adverse effects could be reversed by either lipid peroxides scavenger ferrostatin-1 or overexpression of GPX4. These results suggest that EMP radiation can induce ferroptosis in hippocampal neurons via a vicious cycle of lipid peroxides accumulation and GSH/GPX4 axis downregulation. Lipid peroxides and the GSH/GPX4 axis provide potential effective intervention targets to EMP-induced hippocampal neuronal damage.


Asunto(s)
Ferroptosis , Animales , Ciclooxigenasa 2/metabolismo , Fenómenos Electromagnéticos , Hipocampo/metabolismo , Peróxidos Lipídicos , Neuronas/metabolismo , Fosfolípido Hidroperóxido Glutatión Peroxidasa , Ratas
15.
Micromachines (Basel) ; 13(8)2022 Aug 11.
Artículo en Inglés | MEDLINE | ID: mdl-36014210

RESUMEN

Currently, severe electromagnetic circumstances pose a serious threat to electronic systems. In this paper, the damage effects of a high-power electromagnetic pulse (EMP) on the GaN high-electron-mobility transistor (HEMT) were investigated in detail. The mechanism is presented by analyzing the variation in the internal distribution of multiple physical quantities in the device. The results reveal that the device damage was dominated by different thermal accumulation effects such as self-heating, avalanche breakdown and hot carrier emission during the action of the high-power EMP. Furthermore, a multi-scale protection design for the GaN HEMT against high-power electromagnetic interference (EMI) is presented and verified by a simulation study. The device structure optimization results demonstrate that the symmetrical structure, with the same distance from the gate to drain (Lgd) and gate to source (Lgs), possesses a higher damage threshold compared to the asymmetrical structure, and that a proper passivation layer, which enhances the breakdown characteristics, can improve the anti-EMI capability. The circuit optimization results present the influences of external components on the damage progress. The findings show that the resistive components which are in series at the source and gate will strengthen the capability of the device to withstand high-power EMP damage. All of the above conclusions are important for device reliability design using gallium nitride materials, especially when the device operates under severe electromagnetic circumstances.

16.
Sensors (Basel) ; 22(12)2022 Jun 20.
Artículo en Inglés | MEDLINE | ID: mdl-35746423

RESUMEN

An ultra-wideband electromagnetic pulse (UWB EMP) can be coupled to an FMCW system through metal wires, causing electronic equipment disturbance or damage. In this paper, a hybrid model is proposed to carry out the interference analysis of UWB EMP coupling responses on the wires to the FMCW radar. First, a field simulation model of the radar is constructed and the wire coupling responses are calculated. Then, the responses are injected into an FMCW circuit model via data format modification. Finally, we use the FFT transform to identify the spectral peak of the intermediate frequency (IF) output signal, which corresponds to the radar's detection range. The simulation results show that the type of metal wire has the greatest influence on the amplitude of coupling responses. The spectral peak of the IF output changes to the wrong frequency with the increase of injection power. Applying interference at the end of the circuit can more effectively interfere with the detection of the radar. The investigation provides a theoretical basis for the electromagnetic protection design of the radar.

17.
Materials (Basel) ; 14(3)2021 Jan 30.
Artículo en Inglés | MEDLINE | ID: mdl-33573144

RESUMEN

Polymer-composite materials have the characteristics of light weight, high load, corrosion resistance, heat resistance, and high oil resistance. In particular, graphene composite has better electrical conductivity and mechanical performance. However, the raw materials of graphene composite are processed into semi-finished products, directly affecting their performance and service life. The electromagnetic pulse compaction was initially studied to get the product Graphene/PEKK composite powder. Simultaneously, spark plasma sintering was used to get the bars to determine the electrical conductivity of Graphene/PEKK composite. On the basis of this result, conducting Graphene/PEKK composite powder can be processed by electromagnetic pulse compaction. Finite element numerical analysis was used to obtain process parameters during the electromagnetic pulse compaction. The results show that discharge voltage and discharge capacitance influence on the magnetic force, which is a main moulding factor affecting stress, strain and density distribution on the specimen during electromagnetic pulse compaction in a few microseconds.

18.
Ann Palliat Med ; 9(5): 3418-3427, 2020 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-33065792

RESUMEN

BACKGROUND: The effects of electromagnetic pulse (EMP) radiation on cognitive impairment have attracted much attention, but the mechanism is still unclear. Regulation of brain-derived neurotrophic factor (BDNF) gene expression has been found to promote memory formation and neuronal survival. Isoflurane preconditioning (IP) was reported to have a neuroprotective effect. In this study, we verified the protective effect of IP against brain injury induced by EMP exposure and examined the relation of this effect with BDNF gene regulation. METHODS: Twenty-four hours before EMP exposure, rats were pretreated with 2% inhaled isoflurane for 30 minutes. At 24 hours after EMP injury, the Morris water maze test was carried out. Meanwhile, the other rats were executed and their brain tissues were used for Nissl staining, qRT-PCR, western blot and chromatin immunoprecipitation. RESULTS: The Morris water maze results showed that 2% IP improved the spatial learning and memory ability of the rats. The Nissl staining results showed 2% of IP alleviated neuronal damage. Also, we detected the mRNA and protein expression of BDNF, and 2% IP significantly increased the expression of BDNF. We also found the expression level of histone deacetylase 2 (HDAC2) was increased and that EMP exposure significantly decreased H3 acetylation, while 2% IP reversed these phenomena, individually, BDNF transcription was activated, and neurogenesis after EMP exposure was alleviated. CONCLUSIONS: Our results suggested that 2% of IP alleviates cognitive impairment induced by EMP exposure in rats. Also, the sustained elevated level of BDNF gene transcription may be an essential mechanism for stimulating neurogenesis because of the increased level of HDAC2-dependent H3 acetylation.


Asunto(s)
Lesiones Encefálicas , Isoflurano , Animales , Encéfalo/metabolismo , Factor Neurotrófico Derivado del Encéfalo/genética , Factor Neurotrófico Derivado del Encéfalo/metabolismo , Fenómenos Electromagnéticos , Epigénesis Genética , Ratas , Transcripción Genética
19.
Materials (Basel) ; 13(4)2020 Feb 17.
Artículo en Inglés | MEDLINE | ID: mdl-32079313

RESUMEN

The electromagnetic pulse (EMP) is a destructive phenomenon which harms the building, telecommunication, and IT based infrastructure. Thus, it is required to reduce the effect of EMP using shielding materials. In the present study, we have used different thickness of concrete walls by incorporating 1 and 5 wt% of carbon black, as well as 100 µm thick Zn-Al coating using the arc thermal metal spraying method (ATMSM). The EMP was evaluated using waveguide measurement fixture for shielding performance of the concrete wall in the range of 0.85 to 1 GHz frequency. The results reveal that the maximum value, i.e., 41.60 dB is shown by the 5-300-N specimen before application of Zn-Al coating where the thickness of concrete wall was 300 mm and 5% carbon black. However, once the 100 µm thick Zn-Al coating was applied on concrete specimen, this value was increased up to 89.75 dB. The increase in shielding values around 48 dB after using the Zn-Al coating is attributed to the reflection loss of the metal thermal spray coating. Thus, the Zn-Al coating can be used for EMP application instead of metallic plate.

20.
Materials (Basel) ; 12(20)2019 Oct 15.
Artículo en Inglés | MEDLINE | ID: mdl-31618936

RESUMEN

The aim of this study was to identify and analyze the fatigue fracture characteristics of dissimilar Al 6061 to Cu (UNS C11000) lap joints made with ultrafast electromagnetic pulse welding (EMPW) via fractography, stress analysis and finite element simulation. It was observed that EMPW generated an annular (or ring-shaped) bonding area, with weld zones and a central non-weld zone when viewed from the cross section. Two types of failure modes occurred in relation to the cyclic loading levels: base metal fracture or transverse through-thickness (TTT) crack growth at a higher loading level, and joint interfacial failure at a lower loading level. In the interfacial failure, fatigue crack initiated from the outer edge of annular welding area, and propagated to form an approximate elliptical boundary. Fatigue crack propagation was characterized by fatigue striations existing in discrete areas on the fracture surface. This was attributed to a coupled role of shear and normal stresses present in a tensile lap shear sample due to the bending moment caused by the inherent misalignment. The final rapid fracture started from elliptical boundary with elongated shear dimples. Both theoretical stress analysis and finite element model revealed the maximum stress and stress concentration along the outer edge, where fatigue crack initiation occurred.

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