Human health risks associated to trace elements and metals in commercial fish from the Brazilian Amazon.

Fish constitutes the main protein source for the Amazonian population. However, the impact of different anthropogenic activities on trace element and metal accumulation in fish and their risks for human health at a regional scale remain largely unexplored. Here we assessed exposure levels of 10 trace elements and metals (Cr, Mn, Fe, Ni, Cu, Zn, As, Cd, Pb, and Hg) in 56 samples belonging to 11 different species of fish from the Brazilian Amazon. We studied the relationship between exposure levels, fish origin, and fish feeding habits, and assessed toxicological and carcinogenic risks for the Amazonian population. No significant correlation was found between sampling site and exposure levels to the studied elements, but a significant difference was found between the accumulation of some metals and the position of the fish species in the food chain. The concentrations of Cr and Hg in fish flesh were found to exceed the Brazilian limits for human consumption. This study shows that current fish consumption patterns can lead to estimated daily intakes of Hg, As and Cr that exceed the oral reference dose, thus posing a toxicological concern. Furthermore, carcinogenic risks may be expected due to the continued exposure to Cr and As. The results of this study show that the consumption of wild caught fish in the Amazon region should be controlled. Moreover, continued monitoring of trace element and metal contamination in fish and on the health of the Amazonian population is recommended, particularly for riverine and indigenous communities.

Consent in Limb Lengthening Surgery: Predicting the True Incidence of Material Risk.

Aim: The consent process involves supported decision-making between the surgeon and the patient. Both potential benefits and material risks of the procedure require explanation, with adequate time for reflection. The complexity of limb reconstruction surgery includes the potential for multiple types of complications. In an attempt to delineate the material risks in lower limb lengthening, a literature review was undertaken to ascertain the published rates of complications. Materials and methods: A review of articles from 2003 to 2023 via PubMed and Google Scholar, including keywords 'lengthening', 'tibia', 'lengthening nail' and 'external fixator' was undertaken. Studies with a minimum of 20 patients, undergoing lengthening of the femur, tibia, or both by an external fixator and/or an intramedullary lengthening nail were included for analysis. Complications were reported according to Paley's problems, obstacles, and complications. Results: Twenty-two papers met the inclusion criteria. The commonest complications listed following lengthening using an external fixator were pin site infections (52% in the femur and 18.8% in the tibia), delayed consolidation (8.3%), bone re-fracture (13%), and joint stiffness (18.8%). Following femoral lengthening using the intramedullary lengthening nails reported complication rates were lower, including implant issues (8%) and delayed consolidation (6%). Conclusion: Patients require a full understanding of both benefits and potential harms when undergoing any surgical intervention. Our study has identified the published rates of complications following lower limb lengthening. These figures can be used to guide the consultation and enable surgeons to audit their own surgical results against the published literature. How to cite this article: Makvana S, Robertson A, Britten S, et al. Consent in Limb Lengthening Surgery: Predicting the True Incidence of Material Risk. Strategies Trauma Limb Reconstr 2024;19(2):61-66.

Smartphone-Related Neck Pain: A Study Among Saudi Residents in the Eastern Province.

BACKGROUND: The pervasive use of mobile phones has raised concerns about their impact on musculoskeletal health, particularly neck pain. This issue is notably relevant in the Eastern Province of Saudi Arabia, where high mobile phone usage intersects with demographic diversity. While extensive phone use has been linked to neck pain and other musculoskeletal disorders globally, specific data on this issue in the Eastern Province are limited. This study addresses this gap by examining phone use patterns, neck positions, and associated symptoms in the region. METHODS: Using an online, self-administered survey, this cross-sectional study investigated the relationship between phone use and neck pain in the Eastern Province of Saudi Arabia. Participants aged 18 years and older were recruited via social media, community groups, and university networks. The survey collected data on demographics, phone use patterns, neck positions, awareness of health risks, and pain symptoms. It was pre-tested, administered through Google Forms (Google, Mountain View, CA), and available for four weeks. Data were analyzed using descriptive statistics and cross-tabulations with SPSS 26.0 (IBM Corp., Armonk, NY). RESULTS: The study included 400 participants, with 273 females (68.3%) and 127 males (31.8%). Most participants were single (245, 61.3%) and held a university degree (301, 75.3%). Daily phone use varied: 228 participants (57.0%) used their phones for less than five hours daily, while 43 (10.8%) used them for 10-15 hours or more. Neck positions ranged from 0° to 60°, with 168 participants (42.0%) maintaining a 30° angle. Awareness of health risks associated with phone use was high, with 364 participants (91.0%) aware of these risks. Neck pain was reported by 244 participants (61.0%), with additional symptoms including headache (22 participants, 5.5%) and upper back pain (five participants, 1.3%). CONCLUSION: This study found a significant link between prolonged phone use and neck pain in the Eastern Province of Saudi Arabia. Despite high awareness of the risks, many individuals report discomfort. These findings underscore the need for public health interventions and ergonomic education to improve phone use practices and musculoskeletal health.

Mobilization mechanisms and spatial distribution of arsenic in groundwater of western Bangladesh: Evaluating water quality and health risk using EWQI and Monte Carlo simulation.

Arsenic (As) contamination in groundwater is emerging as a significant global concern, posing serious risks to the safety of drinking water and public health. To understand the release mechanisms, mobilization processes, spatial distribution, and probabilistic health risks of As in western Bangladesh, forty-seven samples were collected and analyzed using an atomic absorption spectrometer (AAS). The As concentrations in groundwater ranged from 1.97 to 697.4 µg L⁻1 (mean: 229.9), significantly exceeding recommended levels. The dominant hydrochemistry of As-enriched groundwater was Ca-Mg-HCO3, with the primary sources of arsenic in groundwater being the dissolution of arsenic-bearing minerals in sediment and the recharge of aquifers from the Ganges River Basin. The assessment using the Entropy Water Quality Index revealed that the groundwater is unsuitable for drinking, with 89.36% (n = 42) of the samples surpassing the WHO's limit for arsenic. Rock-water interactions, including calcite dissolution and silicate weathering within the confined aquifer, predominantly influenced hydrochemical properties. The significant relationships among Fe, Mn, and As indicate that the reductive dissolution of FeOOH and/or MnOOH considerably contributes to the release of As from sediment into groundwater. Geochemical modeling analysis revealed that siderite and rhodochrosite precipitate into aquifer solids, suggesting a weak to moderate relationship among As, Fe, and Mn. The long residence time of groundwater, combined with the presence of a clayey aquitard, likely controls the mobilization of arsenic in the aquifer. For the first time, Monte Carlo simulations have been used in arsenic-prone areas to assess the severity of arsenic contamination in western Bangladesh. The analysis indicates that out of 100,000 people, 10 may develop cancer as a result of drinking arsenic-contaminated water, with children being more susceptible than adults.

The burden of type 2 diabetes attributable to dietary risks in China: Insights from the global burden of disease study 2021.

OBJECTIVES: This study aims to comprehensively assess how dietary risk factors have influenced the prevalence of Type 2 Diabetes Mellitus (T2DM) in China from 1990 to 2021. The study seeks to provide robust data and scientific evidence essential for formulating effective preventive and control strategies to combat T2DM in China. STUDY DESIGN: This cross-sectional study conducted secondary analyses using data from the Global Burden of Disease 2021 (GBD 2021) to assess the burden of T2DM in China attributable to dietary risks. METHODS: The study analyzed age-adjusted metrics related to T2DM, including death counts, Disability-Adjusted Life Years (DALYs), and Age-Standardized Rates (ASRs), using GBD 2021 data, stratified by age and sex. Additionally, Estimated Annual Percentage Changes (EAPCs) were employed to track trends over time. RESULTS: In 2021, the results show that 21.43 % of T2DM-related deaths and 23.51 % of DALYs were attributable to dietary risk factors, notably a diet low in whole grains and high in red and processed meats. Over the period from 1990 to 2021, there has been an increasing trend in the EAPCs of death rates and DALYs associated with dietary risks in China, suggesting a substantial impact of dietary factors on the burden of T2DM in the country. CONCLUSION: This study highlights the urgent need for targeted public health interventions to promote dietary changes and reduce the burden of T2DM in China.

Evaluation of the Smokeless Tobacco Awareness, Attitude, and Response Knowledge (STAARK) Scale With Integrated Risk Assessment for Tailored Intervention.

Background Smokeless tobacco (SLT) use, particularly gutkha, is prevalent in India, with cultural acceptance contributing to widespread use, especially among tribal populations. Despite awareness programs, there is limited assessment of their effectiveness, leading to continued vulnerability, even among educated groups. This study aims to evaluate public health strategies by developing and validating the SLT Awareness, Attitude, and Response Knowledge (STAARK) scale, which assesses knowledge and attitudes post-awareness programs on SLT usage through questionnaires, identifying vulnerable individuals, and enabling targeted interventions to reduce SLT use and associated health risks, particularly through integrated risk assessment (IRA). Methods This study was performed during an SLT awareness program in Nagaland, utilizing a comprehensive survey to assess participants' demographics, knowledge, and attitudes. The STAARK score was calculated by combining normalized attitude and knowledge scores, ranging from 0 to 10, categorizing participants' comprehension and attitudes toward SLT usage awareness. The obtained scores were assessed twice for consistency evaluation of the scale, and vulnerable individuals were subjected to IRA for targeted intervention recommendations. Reliability and correlation analyses were performed, with Cronbach's alpha validating the scale's internal consistency. Results About 182 participants took up the assessment, with only 180 completing the survey among the population attending the awareness program. Demographic data revealed a diverse participant group, with ages ranging from 13 to 42 years. The survey assessed participants' knowledge and attitudes toward SLT, scoring them on a 0-10 scale for knowledge and a 10-60 scale for attitude. The STAARK scale was developed to combine these scores, providing a comprehensive measure of participants' understanding and attitudes toward SLT. The mean STAARK score was 5.27 with an observed lower limit of 2.40 and an upper limit of 6.50 in the responded population. Reliability testing using Cronbach's alpha showed acceptable internal consistency, though attitude had a weaker correlation with the overall STAARK score compared to knowledge. In a follow-up assessment with 88 participants, the STAARK score averaged 5.10, reinforcing the initial findings. The risk assessment of 17 participants with STAARK scores above six identified varying levels of risk, with most falling into the low- or moderate-risk categories. The study highlights the importance of targeted interventions to address SLT usage, particularly in populations with lenient attitudes toward its consumption. Conclusions The STAARK scale can serve as a key tool for evaluating SLT awareness programs by assessing participants' knowledge and attitudes and identifying high-risk individuals requiring personalized interventions for SLT usage cessation. It standardizes the assessment, enabling comparison across groups and times, and helps identify individuals with lenient attitudes toward SLT for targeted interventions. Its reliability ensures consistency, and by tracking changes in scores before and after programs, it assesses impact and guides future improvements. The STAARK scale is crucial for personalized, evidence-based public health efforts to reduce SLT use. However, eradicating SLT requires ongoing commitment, adaptability, and a focus on long-term outcomes to translate knowledge into lasting change.

Assessment of environmental and health risks of potentially toxic elements associated with desert dust particles affected by industrial activities in Isfahan metropolitan.

Dust particles and their associated compounds can adversely affect human health and ecosystems. The aim of this study was to investigate the concentration, health, and ecological risks of selected potentially toxic elements (e.g. Pb, Cd, Cr, Co, Cu, Zn, V, Ni, and As) bound to air particles generated by dust storms in the Sejzi plain desert area within the industrial district of Isfahan metropolitan, Iran. The enrichment factor revealed the highest values for Zn, Pb, and Cd which among them Zn showed the highest value (8.1) with the potential source of industrial activities confirmed by the integrated pollution index, accumulation coefficient, and ecological risk index. Regarding health risk analysis (non-cancer and cancer risks) the elements including Co, As, and Cr showed a significant risk for adults and children across all seasons. It's concluded that mitigation of air particles originated from both natural and industrial activities is necessary to reduce their relevant risks to human being and ecosystems in the region.

Testing Similarity of Parametric Competing Risks Models for Identifying Potentially Similar Pathways in Healthcare.

The identification of similar patient pathways is a crucial task in healthcare analytics. A flexible tool to address this issue are parametric competing risks models, where transition intensities may be specified by a variety of parametric distributions, thus in particular being possibly time-dependent. We assess the similarity between two such models by examining the transitions between different health states. This research introduces a method to measure the maximum differences in transition intensities over time, leading to the development of a test procedure for assessing similarity. We propose a parametric bootstrap approach for this purpose and provide a proof to confirm the validity of this procedure. The performance of our proposed method is evaluated through a simulation study, considering a range of sample sizes, differing amounts of censoring, and various thresholds for similarity. Finally, we demonstrate the practical application of our approach with a case study from urological clinical routine practice, which inspired this research.

Mechanistic insight into interactive effect of microplastics and arsenic on growth of rice (Oryza sativa L.) and soil health indicators.

Microplastics (MPs) pollution has recently become a major concern for agroecosystems. The interplay between MPs, and heavy metal(loid)s in the soil can intensify the risks to plant growth and human health. The current study investigated the interactive effects of arsenic (As) and biodegradable and petroleum-based conventional MPs on rice growth, As bioavailability, soil bacterial communities, and soil enzyme activities. As-contaminated soil (5 mg kg-1) was treated with conventional MPs i.e., polystyrene (PS) and polyethylene (PE) and biodegradable MPs i.e., polylactic acid (PLA) and polybutylene adipate terephthalate (PBAT) at 0.1 % and 1 % rates. In a pot experiment, rice plants were cultivated in soil co-contaminated with As and MPs. PLA-MPs exhibited significant interactions with As, increasing its bioavailability and impairing rice plant growth by enhancing plant oxidative stress. The results illustrated that T2 treatment (PLA-MPs @ 1 % + As 5 mg kg-1) significantly decreased the root and shoot lengths, root and shoot dry weights as well as the rates of photosynthesis, transpiration, intercellular CO2, and stomatal conductance in rice plants. Biodegradable PLA-MPs @ 1 % resulted in increased uptake of As in rice roots, stems, and leaves by 13.4 %, 38.9 %, and 20.6 %, respectively. In contrast, conventional PE-MPs @ 1 % showed contradictory results with As uptake declined by 2.2 %, 5.1 %, and 9.9 % in rice roots, stem and leaves. Soil enzyme kinetics showed that biodegradable MPs increased the activities of soil catalase, dehydrogenase, and phytase enzymes, whereas both conventional PS and PE-MPs decreased their activities. Moreover, As and PLA-MPs combined stress altered soil bacterial communities by increasing the relative abundance of Protobacteria, Acidobacteria, Chloroflexi, and Firmicutes phyla by 49 %, 29 %, 82 %, and 57 %, respectively. This study provides new insights into MPs-As interactions in soil-plant system and ecological risks associated with their coexistence.

Assessing the asymmetric interrelationships between sovereign bond yields and selected potential determinants: The case of frontier WAMZ economies.

The spot of frontier market economies in the global financial arena continues to be significant for many market participants because of their size, diversification advantage, and interconnectedness. Financial market innovations, globalization and pandemics have made it even more urgent to explore their dynamics. This paper focuses on analysing the risks associated with investing in frontier West African monetary zone bonds by appropriately modelling them in relation to cultural, administrative/political, geographic, economic and financial indicators that are specific to these countries, primarily due to their locations and interlinkages. This study employed the nonlinear autoregressive distributed lag model to investigate the asymmetric effects of different economic factors on sovereign bond yields in Ghana and Nigeria from July 2014 to September 2022 with 99 observations. Period selection allows researchers to unravel the complexities of market behaviour, investor sentiment, and policy effectiveness in the face of economic turmoil and uncertainty. The results provide valuable insights into how these factors affect bond yields differently in the two countries.

Direct quantitative comparison of benefits and risks of COVID-19 vaccines used in National Immunization Technical Advisory Groups Guidance during the first two years of the pandemic.

INTRODUCTION: The balance of benefits and harms of vaccines are assessed by regulatory agencies and National Immunization Technical Advisory Groups (NITAGs) to inform vaccine authorization or guidance. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach has been adopted by many NITAGs to develop recommendations. During the COVID-19 pandemic, several NITAGs additionally used direct quantitative comparisons (DQCs) between benefits and risk of vaccination with or without a GRADE framework to support timely decision-making relating to emerging safety signals. This study aimed to document the role of DQCs as novel tools in NITAGs' work by identifying situations where DQCs have been clearly leveraged in NITAG guidance, as well as identifying their strengths and limitations. METHODS: The MEDLINE database and NITAGs' websites listed in the Global NITAG Network were searched for NITAG publications on COVID-19 vaccines. Publications were included if a DQC between benefits and risks of any COVID-19 vaccine was explicitly used for NITAG decision-making. Two reviewers independently assessed publication eligibility and extracted data. A narrative description of the role of DQCs in NITAG guidance, DQCs' methods and limitations was conducted. RESULTS: Overall, 23 publications with 18 DQCs used by seven NITAGs were included. Situations prompting these publications included new safety signals (n = 7), additional information available on previously identified safety signals (n = 4) and changing contexts (n = 15) (e.g., vaccine supply, and epidemiology). DQC simplicity made them accessible, timely, and allowed for transparent communication. DQCs heavily relied on assumptions making them sensitive to changes in model parameters. DQCs limitations made them not easily transferable to other contexts and they quickly became obsolete in the evolving context of the COVID-19 pandemic. CONCLUSIONS: The use of DQCs by NITAGs during the COVID-19 pandemic allowed for rapid evidence-based decision-making in an evolving environment while maintaining public trust. However, if their use becomes standard practice, efforts should be made to address their limitations.

Risk assessment of PM2.5 from fossil energy consumption on the respiratory health of the elderly.

Air pollution mainly comes from fossil energy consumption (FEC), and it brings great threat to public health. The respiratory system of the elderly is highly susceptible to the effects of air pollution due to the decline in body functions. PM2.5 is a major component of air pollution, so the study of the impact of PM2.5 generated by FEC on the respiratory health of the elderly is of great significance. The existing studies have focused more on the effect of PM2.5 on mortality, and this paper is a useful addition to the existing studies by examining the effect of PM2.5 from FEC on the health of the elderly from the perspective of prevalence. In this paper, the binary Logistic regression model was used to calculate the exposure-response relationship coefficient for respiratory health in older adults using the data in 2018 from the Chinese Longitudinal Healthy Longevity Survey. And referring to the Dynamic Projection model for Emissions in China, the changes in the number of older persons suffering from respiratory diseases due to PM2.5 from FEC in the baseline scenario, the clean air scenario, and the on-time peak-clean air scenario were predicted. The results indicated that: (1) PM2.5 from FEC mainly came from coal; (2) PM2.5 from FEC was detrimental to the respiratory health of the elderly, and older seniors were more affected as they age; (3) In the on-time peak-clean air scenario, the number of elderly people suffering from respiratory diseases due to PM2.5 from FEC was growing at the slowest rate. Based on the above results, this paper raised recommendations for reducing the effect of PM2.5 from FEC on the health of the elderly.

Soil benzene emissions and inhalation health risks affected by various land covers.

Accurate quantification of soil volatile organic compounds (VOCs) flux is crucial for assessing inhalation environmental health risks and developing region-specific remediation strategies. However, land cover significantly influences VOCs emissions from soil. This study investigated benzene, a representative VOCs, using a laboratory flux chamber and numerical simulations to evaluate its release patterns under different surface covers, including bare soil (no cover), clay brick, cement, and grass. In the experiment, gaseous benzene was collected using an adsorption tube filled with Tenax-TA adsorbent. The collected samples were subsequently analyzed using thermal desorption coupled with gas chromatography-mass spectrometry. By integrating these findings with environmental health risk assessment methodologies, we developed a tailored approach for assessing inhalation health risks at benzene-contaminated sites with varying land covers. Additionally, we conducted application studies of this method across various scenarios. The results indicate that soil benzene emissions could be reduced by using low-permeability coverings such as clay brick and cement, as well as by planting vegetation. The average fluxes of benzene through covering materials were of the order of 1.22 × 10-2, 4.37 × 10-3, 2.47 × 10-3, and 9.88 × 10-4 mg m-2·s-1 for bare soil, clay brick, grass, and cement, respectively. The application of clay brick and cement coverings on the soil surface results in more pollutants remaining in the soil in liquid and adsorbed states, making them less likely to volatilize. The inhalation carcinogenic risk (CR) values for soil benzene at an abandoned oil refinery site in Northwestern China under bare soil, brick, and cement cover are 1.3 × 10-6, 1.22 × 10-6, and 9.73 × 10-7, respectively. Low-permeability covers such as clay brick and cement reduces the inhalation CR of gaseous benzene from the surface soil, and delays the growth trend of cumulative inhalation CR.

Composite endpoints in COVID-19 randomized controlled trials: a systematic review.

BACKGROUND/AIMS: This study aimed to determine the prevalence of ordinal, binary, and numerical composite endpoints among coronavirus disease 2019 trials and the potential bias attributable to their use. METHODS: We systematically reviewed the Cochrane COVID-19 Study Register to assess the prevalence, characteristics, and bias associated with using composite endpoints in coronavirus disease 2019 randomized clinical trials. We compared the effect measure (relative risk) of composite outcomes and that of its most critical component (i.e. death) by estimating the Bias Attributable to Composite Outcomes index [ln(relative risk for the composite outcome)/ln(relative risk for death)]. RESULTS: Composite endpoints accounted for 152 out of 417 primary endpoints in coronavirus disease 2019 randomized trials, being more frequent among studies published in high-impact journals. Ordinal endpoints were the most common (54% of all composites), followed by binary or time-to-event (34%), numerical (11%), and hierarchical (1%). Composites predominated among trials enrolling patients with severe disease when compared to trials with a mild or moderate case mix (odds ratio = 1.72). Adaptations of the seven-point World Health Organization scale occurred in 40% of the ordinal primary endpoints, which frequently underwent dichotomization for the statistical analyses. Mortality accounted for a median of 24% (interquartile range: 6%-48%) of all events when included in the composite. The median point estimate of the Bias Attributable to Composite Outcomes index was 0.3 (interquartile range: -0.1 to 0.7), being significantly lower than 1 in 5 of 24 comparisons. DISCUSSION: Composite endpoints were used in a significant proportion of coronavirus disease 2019 trials, especially those involving severely ill patients. This is likely due to the higher anticipated rates of competing events, such as death, in such studies. Ordinal composites were common but often not fully appreciated, reducing the potential gains in information and statistical efficiency. For studies with binary composites, death was the most frequent component, and, unexpectedly, composite outcome estimates were often closer to the null when compared to those for mortality death. Numerical composites were less common, and only two trials used hierarchical endpoints. These newer approaches may offer advantages over traditional binary and ordinal composites; however, their potential benefits warrant further scrutiny. CONCLUSION: Composite endpoints accounted for more than a third of coronavirus disease 2019 trials' primary endpoints; their use was more common among studies that included patients with severe disease and their point effect estimates tended to underestimate those for mortality.

Risk Assessment Suicidality Scale (RASS)-Based On-Line Calculator Targeting Early Prevention of Suicides in General Population: from COMET-G Study Results Towards Integration of the Screening Tool into Routine Clinical Practice.

BACKGROUND: Suicide is a major global health concern, particularly among young people. This study evaluates an online suicide risk calculator based on the Risk Assessment of Suicidality Scale (RASS), which is designed to enhance accessibility and early detection of suicide risk. METHODS: The study involved 444 participants who completed the RASS via an online calculator. Results were compared with data from the COMET-G study's Russian sample (n=7572). Descriptive statistics, correlation analysis, and two-way ANOVA were used to analyze the data. RESULTS: The mean age of participants was 22.71 years (SD=7.94). The mean total RASS standardized score was 837.7 (SD=297.8). There was a significant negative correlation between age and RASS scores (r=-0.463, p<0.0001). The online calculator sample showed significantly higher RASS scores compared to the COMET-G sample, with 71% of online users scoring above the 90th percentile of the COMET-G sample. CONCLUSION: Our study demonstrated the advantage of the on-line suicidality risk calculator based on the RASS scale as a sensitive tool in detecting suicidal behaviours and measuring the severity of suicidality risks, offering a capability for broad reach and immediate assessment during clinical conversation between doctor and patient. Moreover, the RASS on-line psychometric instrument, when being freely distributed among the general population over internet sources, enabled to attract vulnerable groups of respondents with significantly higher suicidality risks. Future research should focus on integrating such tools into comprehensive suicide prevention programs and developing appropriate follow-up monitoring strategies for high risk-cases.

Parabens as the double-edged sword: Understanding the benefits and potential health risks.

Parabens are globally employed as important preservatives in pharmaceutical, food, and personal care products. Nonetheless, improper disposal of commercial products comprising parabens can potentially contaminate various environmental components, including the soil and water. Residues of parabens have been detected in surface water, ground water, packaged food materials, and other consumer items. Long-term exposure to parabens through numerous consumer products and contaminated water can harm human health. Paraben can modulate the hormonal and immune orchestra of the body. Recent findings have correlated paraben use with hypersensitivity, obesity, and infertility. Notably, parabens have also been detected in the samples of breast cancer patients, suggesting a potential cross-talk between parabens and carcinogenesis. Therefore, the present article aims to dissect the significance of parabens as a preservative in several consumer products and their impact of chronic exposure to human health. This review encompasses various facets of paraben, including its sources, mechanism of action at the molecular level, and sheds light on its toxicological implications on human health.

Invisible hazards: Exploring neonicotinoid contamination and its environmental risks in urban parks across China.

Neonicotinoids (NEOs) are commonly used pesticides in agriculture. Urban parks containing numerous green plants and flowers also require NEOs for pest control. However, information on the distribution patterns and environmental risks of NEOs and their metabolites in urban park soils has yet to be discovered, which seriously limits the comprehensive evaluation of the potential hazards of NEOs. Our study explored the occurrence and distribution patterns of ten NEOs and five major metabolites in park soils from Guangzhou, Shijiazhuang, and Urumqi of China. At least three NEOs were detected in 95 % of soil samples, with the sum of all NEOs (∑10NEOs) ranging from 2.21 to 204 ng/g. Guangzhou has the highest levels of ∑10NEOs (median: 52.1 ng/g), followed by Urumqi (49.3 ng/g) and Shijiazhuang (21.7 ng/g). The top three most common NEOs in all three cities are imidacloprid, acetamiprid, and thiacloprid, which together account for 67 % to 70 % of ∑10NEOs. The levels of the metabolites of NEOs show a significant positive correlation with their corresponding parent NEOs. These NEOs pose detrimental effects to non-targeted invertebrates in the soil. Our findings raise concern about the environmental risks posed by NEO exposure to humans and other organisms in urban parks.

A systematic literature review of driver behaviour in blind spot: Assessing risk and influencing factors for enhanced ergonomics in vehicle design.

Risk associated with vehicle blind spot is a critical concern for road traffic safety that poses a serious threat to drivers as well as vulnerable road users. While driving on the road, it is necessary for drivers to check their mirrors before attempting lane changing, overtaking, turning, or any kind of manoeuvring pattern. But still, there remains some areas around the vehicle that are not visible to driver's peripheral vision even through checking mirrors, known as vehicle blind spots. In this systematic literature, an overview of the blind spot of vehicles along with the associated risks are explained thoroughly by emphasising its importance by focusing on safety aspects. The considered factors included size and visibility of blind spot, demographic factors that influence drivers' awareness and behaviour in blind spot; vehicle characteristics associated with design of different components, and also the efficacy of mirrors in enhancing visibility of blind spots. A quick and concise summary of the literature is highlighted in the current review, and finally, some future directions are proposed to not only help the researchers for a better understanding of blind spot-related driver behavioural issues but also benefit the automotive industry and policymakers to make roads safer.

Insightful information on enhancing drivers' awareness while driving and affecting factors associated with the risk due to blind spot are explored comprehensively. Conducting this systematic review will not only help the researchers but also benefit the automotive industry and policymakers in developing better vehicle design and advanced road safety policy, respectively.

Lower Incidence of Dementia Following Cancer Diagnoses: Evidence from a Large Cohort and Mendelian Randomization Study.

BACKGROUND: The reported inverse association between cancer and subsequent Alzheimer's disease and related dementias (ADRD) remains uncertain. OBJECTIVES: To investigate the association between these common conditions of old age and explore possible causal factors. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: We conducted a large population-based cohort analysis using data from 3,021,508 individuals aged 60 and over in the UK Clinical Practice Research Datalink (CPRD), over a period up to 30 years (1988-2018). Cox proportional hazards models were fitted to estimate hazard ratios (HR) for risk of dementia associated with previous cancer diagnosis. Competing risk models were employed to account for competing risk of death. Two-sample Mendelian Randomization analysis based on meta-analysis data from large-scale GWAS studies was also conducted. RESULTS: In the CPRD cohort, 412,903 participants had cancer diagnosis and 230,558 were subsequently diagnosed with dementia over a median follow-up period of 7.9 years. Cancer survivors had a 25% lower risk of developing dementia (HR=0.75, 95% CI:0.74-0.76) after adjustment for potential confounders. Accounting for competing risk of death provided a sub-distribution HR of 0.56 (95% CI:0.55-0.56). Results were consistent for prevalent and incident cancer and different common cancer types. Two-sample Mendelian Randomization analysis, using 357 cancer-related instrumental single-nucleotide polymorphisms (SNPs) revealed evidence of vertical pleiotropy between genetically predicted cancer and reduced risk of Alzheimer's disease (OR=0.97,95% CI:0.95-0.99). CONCLUSION: Our results provide strong epidemiological evidence of the inverse association between cancer and risk of ADRD and support the potential causal nature of this association via genetic instruments. Further investigations into the precise underlying biological mechanisms may reveal valuable information for new therapeutic approaches.