RESUMEN
Itraconazole (ITZ) is the most used drug to treat feline sporotrichosis; however, little is known about its pharmacokinetics in cats with this mycosis. The aim of this study was to determine plasma ITZ concentrations in cats with sporotrichosis treated with ITZ as monotherapy or in combination with potassium iodide (KI). Cats diagnosed with sporotrichosis received orally ITZ (100 mg/cat/day) or combination therapy with ITZ (100 mg/cat/day) and KI (2.5-5 mg/kg/day) in the case of worsening or stagnation of the clinical condition. At each monthly visit, blood samples were collected at an interval of 4 h for analysis of trough and peak plasma ITZ concentrations by HPLC. Clinical features and laboratory parameters were evaluated during follow-up. Sixteen cats were included in the study. The median plasma ITZ concentration of all cats was 0.75 µg/mL. The median plasma ITZ concentration was 0.5 µg/mL in cats that received ITZ monotherapy (n = 12) and 1.0 µg/mL in those treated with ITZ + KI (n = 4). The clinical cure rate was 56.3% (n = 9) and the median treatment duration was 8 weeks. Nine cats (56.3%) developed adverse clinical reactions, and hyporexia was the most frequent (n = 8; 88.9%). Serum alanine aminotransferase was elevated in four cats (25%). The median plasma ITZ concentration detected in cats was considered to be therapeutic (>0.5 µg/mL) and was reached after 4 weeks of treatment. Plasma ITZ concentrations were higher in cats that received ITZ + KI compared to those treated only with ITZ, suggesting pharmacokinetic synergism between these drugs.
Itraconazole is the most common therapy for feline sporotrichosis, and combination therapy with potassium iodide is used in nonresponsive cases. Our study showed that all cats achieved a therapeutic plasma concentration of itraconazole, with higher levels in cats treated with the combination therapy.
Asunto(s)
Antifúngicos , Enfermedades de los Gatos , Itraconazol , Yoduro de Potasio , Esporotricosis , Animales , Gatos , Esporotricosis/tratamiento farmacológico , Esporotricosis/veterinaria , Esporotricosis/sangre , Itraconazol/sangre , Itraconazol/farmacocinética , Itraconazol/administración & dosificación , Itraconazol/uso terapéutico , Enfermedades de los Gatos/tratamiento farmacológico , Enfermedades de los Gatos/sangre , Enfermedades de los Gatos/microbiología , Antifúngicos/farmacocinética , Antifúngicos/sangre , Antifúngicos/uso terapéutico , Antifúngicos/administración & dosificación , Masculino , Yoduro de Potasio/uso terapéutico , Yoduro de Potasio/administración & dosificación , Yoduro de Potasio/farmacocinética , Femenino , Resultado del Tratamiento , Quimioterapia Combinada , Administración Oral , Plasma/químicaRESUMEN
Potassium iodide has demonstrated several therapeutic applications over time, being the choice for shielding the thyroid during radiation emergencies involving radioiodine release. Amidst the ongoing military conflict between Ukraine and Russia and the growing concern regarding the potential deployment of nuclear weapons, there has been a surge in the demand for potassium iodide across Europe. This work aimed to comprehensively review the current knowledge regarding the pharmacology, physiology, adverse effects, the protective role in reducing the risk of thyroid cancer and recommendations for potassium iodide use during radiation emergencies. Evidence on adverse effects is scarce, as potassium iodide is generally well-tolerated. Guidelines for thyroid blocking with potassium iodide during radiation emergencies suggest that, among populations vulnerable to radioiodine exposure, the benefits of potassium iodide outweigh the risks of adverse effects. Controversial topics surrounding the utilization of potassium iodide in radiation emergencies include the prophylaxis in iodine-deficient regions and following the detonation of dirty bombs, whether granule formulations versus tablets should be used and mental health concerns. Although the rise in demand seems to be a justified security measure, it is essential to recognize that potassium iodide protects the thyroid from radioiodine and does not impact the body's absorption of other radioactive materials or defend against external radiation exposure.
Asunto(s)
Yoduro de Potasio , Yoduro de Potasio/uso terapéutico , Humanos , Ucrania , Europa (Continente) , Glándula Tiroides/efectos de la radiación , Glándula Tiroides/efectos de los fármacos , Radioisótopos de Yodo/efectos adversos , Protectores contra Radiación/uso terapéutico , Neoplasias de la Tiroides , Traumatismos por Radiación , Animales , Armas NuclearesRESUMEN
BACKGROUND: The black staining effect of silver-containing solutions for use to arrest caries can have a negative aesthetic impact on children and parents. This study aims to assess the staining effects of Silver Diamine Fluoride/Potassium Iodide (SDF/KI), SDF and Nanosilver Fluoride (NSF). MATERIALS AND METHODS: Forty-four extracted carious primary molars were collected and randomly divided into four groups (n = 11). The carious tissue in all teeth was removed using a chemo-mechanical caries removal agent with an excavator. After caries removal in all groups, SDF, SDF/KI, and NSF were applied to the different groups, while no solution was applied to the control group. Subsequently, the teeth in all groups were restored with compomer. Color values L*, a* and b* were measured using a spectrophotometer at three time points: immediately after compomer restoration (T0), one week later (T1), and four week later (T2). Changes in brightness (ΔL) and color (ΔE) over time were calculated and comparisons among groups were made. RESULTS: The SDF solution induced statistically significant black staining (p = 0.013) and a decrease in L* value (p < 0.001) on the compomer material compared to the other groups over time. CONCLUSIONS: It was observed that SDF/KI has the potential to reduce the black staining effect of SDF, though not entirely. Novel experimental solutions like NSF may offer an alternative to counteract the staining effect of SDF.
Asunto(s)
Fluoruros Tópicos , Yoduro de Potasio , Compuestos de Amonio Cuaternario , Compuestos de Plata , Compuestos de Amonio Cuaternario/farmacología , Compuestos de Amonio Cuaternario/uso terapéutico , Yoduro de Potasio/uso terapéutico , Humanos , Fluoruros Tópicos/uso terapéutico , Técnicas In Vitro , Cariostáticos/uso terapéutico , Caries Dental/prevención & control , Decoloración de Dientes/inducido químicamente , Diente Primario , Espectrofotometría , Diente MolarRESUMEN
OBJECTIVE: To evaluate the effect of the association of potassium iodide to antimicrobial photodynamic therapy on human carious dentin produced with a microcosm biofilm model. METHODS: A microcosm biofilm model was used to generate a caries lesion on human dentin. Pooled human saliva diluted with glycerol was used as an inoculum on specimens immersed on McBain artificial saliva enriched with 1 % sucrose (24 h at 37 °C in 5 % CO2). After refreshing culture media for 7 days, the dentin specimens were divided in 5 groups (3 specimens per group, in triplicate; n = 9): C (NaCl 0.9 %), CX (2 % chlorhexidine), PKI (0.01 % methylene blue photosensitizer+50 mM KI), L (laser at 15 J, 180 s, 22.7 J/cm2), and PKIL (methylene blue + KI + Laser). After the treatments, dentin was collected, and a 10-fold serial dilution was performed. The number of total microorganisms, total lactobacilli, total streptococci, and Streptococcus mutans was analyzed by microbial counts (CFU/mL). After normality and homoscedasticity analysis, the Welch's ANOVA and Dunnett's tests were used for CFU. All tests used a 5 % significance level. RESULTS: CX and PKIL groups showed significant bacterial decontamination of dentin, compared to group C (p < 0.05) reaching reductions up to 3.8 log10 for CX for all microorganisms' groups and PKIL showed 0.93, 1.30, 1.45, and 1.22 log10 for total microorganisms, total lactobacilli, total streptococci, and S. mutans, respectively. CONCLUSION: aPDT mediated by the association of KI and methylene blue with red laser reduced the viability of microorganisms from carious dentin and could be a promising option for cavity decontamination.
Asunto(s)
Biopelículas , Caries Dental , Dentina , Azul de Metileno , Fotoquimioterapia , Fármacos Fotosensibilizantes , Yoduro de Potasio , Streptococcus mutans , Humanos , Azul de Metileno/farmacología , Azul de Metileno/uso terapéutico , Fotoquimioterapia/métodos , Caries Dental/microbiología , Caries Dental/tratamiento farmacológico , Caries Dental/terapia , Dentina/microbiología , Dentina/efectos de los fármacos , Yoduro de Potasio/farmacología , Yoduro de Potasio/uso terapéutico , Biopelículas/efectos de los fármacos , Streptococcus mutans/efectos de los fármacos , Fármacos Fotosensibilizantes/uso terapéutico , Fármacos Fotosensibilizantes/farmacología , Saliva/microbiología , Lactobacillus/efectos de los fármacos , Streptococcus/efectos de los fármacos , Clorhexidina/farmacología , Clorhexidina/uso terapéutico , Técnicas In Vitro , Recuento de Colonia Microbiana , Saliva Artificial , Rayos LáserRESUMEN
OBJECTIVES: This study aimed to assess the clinical outcomes of utilizing silver diamine fluoride + potassium iodide (SDF + KI) treatment and Silver-Modified Atraumatic Restorative Technique (SMART/SDF + KI + Glass Ionomer Cement) over a three-year period on hypomineralised permanent molars with initial carious lesions. METHODS: 112 hypomineralised permanent molars with ICDAS 1 or 2 lesions were selected in 48 children. The teeth were randomized into SDF + KI and SMART (SDF + KI + GIC) groups (n = 56 teeth/group) in a split-mouth design. Hypersensitivity and caries development were evaluated in both groups. Schiff Cold Air Sensitivity Scale (SCASS) was used for evaluation of hypersensitivity, and the modified USPHS criteria were utilised for clinical assessments of SMART sealants at 1,6,12,18,24 and 36 months. Fisher's Exact test, Kaplan-Meier Survival Curves, Log-rank test, Mann Whitney U test, and Friedman test was performed for the statistical analysis. RESULTS: The caries preventive effect was 100 %, 67.9 % and 65.4 % for SDF + KI-treated teeth; and 100 %, 97.6 % and 94.7 % for SMART(SDF + KI + GIC)-treated teeth at 12, 24 and 36 months, respectively. The mean survival probabilities for caries-preventive effect were significantly lower in SDF + KI-treated teeth (31.01 months) than SMART-treated teeth (35.61 months), (p < 0.001). Twenty-six molars with initial hypersensitivity due to hypomineralization demonstrated a significant reduction at all evaluation periods compared to baseline SCASS scores (p < 0.001). Additionally, there was no significant difference in hypersensitivity scores between the groups during the re-call periods, and none of the teeth exhibited hypersensitivity at the 18-month and beyond evaluations. CONCLUSIONS: During the three-year assessment, both groups demonstrated effectiveness in reducing sensitivity in hypomineralised molars. However, SMART (SDF + KI + GIC) sealants offered better protection against tooth decay over time, despite experiencing gradual retention loss. CLINICAL SIGNIFICANCE: Both SMART (SDF + KI + GIC) sealants and SDF + KI proved effective in alleviating hypersensitivity in hypomineralised molars for up to three years. SMART (SDF + KI + GIC) sealants showed greater caries-preventive effect compared to SDF + KI. However, continuous long-term monitoring is crucial due to the gradual decline in retention of SMART (SDF + KI + GIC) sealants. CLINICALTRIALS REGISTRATION NUMBER: NCT03862014.
Asunto(s)
Cariostáticos , Caries Dental , Sensibilidad de la Dentina , Fluoruros Tópicos , Cementos de Ionómero Vítreo , Diente Molar , Yoduro de Potasio , Compuestos de Amonio Cuaternario , Compuestos de Plata , Humanos , Compuestos de Plata/uso terapéutico , Caries Dental/prevención & control , Compuestos de Amonio Cuaternario/uso terapéutico , Fluoruros Tópicos/uso terapéutico , Masculino , Femenino , Estudios Prospectivos , Niño , Cementos de Ionómero Vítreo/uso terapéutico , Yoduro de Potasio/uso terapéutico , Cariostáticos/uso terapéutico , Sensibilidad de la Dentina/prevención & control , Resultado del Tratamiento , Tratamiento Restaurativo Atraumático Dental/métodos , Selladores de Fosas y Fisuras/uso terapéutico , Estudios de SeguimientoRESUMEN
OBJECTIVES: Silver fluoride (SF) is a preventive and therapeutic option for dental pathological processes involving structural alterations of the hard tissues, either during their formation or those caused by caries or other pathological reasons. This study aimed to compare the biological properties of two commercial SF products, one of them with ammonium (Riva Star; SDF) and the other ammonium-free (Riva Star Aqua; AgF), both with or without potassium iodide (KI), by the assessment of the cytotoxicity of the materials' eluates. METHODS: Human dental pulp stem cells (hDPSCs) were obtained from healthy 18-23-year-old donors. Three dilutions were prepared for the tested materials (0.005%, 0.0005%, and 0.0001%). The following groups were assessed: (AgF, AgF+KI, SDF, SDF+KI, KI, negative control). A series of cytocompatibility assays were performed: MTT assay, IC50 assay, wound healing (migration) assay, cell cytoskeleton staining, analysis of cell apoptosis and necrosis, and reactive oxygen species production. The normality in the distribution of the data was previously confirmed via a Q-Q plot. Statistical significance was tested using one way ANOVA and Tukey's post hoc test. RESULTS: The incorporation of KI improved the cytocompatibility of both SF products in terms of viability, migration, morphology, apoptosis, and reactive oxygen species production. This difference was higher in the AgF group. The lowest dilutions of SF+KI and AgF+KI showed a similar cytocompatibility to that of the control group (MTT assay (p > 0.05 after 24, 48, and 72 h of culture); migration assay (p > 0.05 after 24, 48, and 72 h of culture); reactive oxygen species production (p > 0.05 after 72 h of culture). SIGNIFICANCE: Riva Star Aqua shows lower cytotoxicity than Riva Star on hDPSCs. It can be considered as a good alternative in the conservative treatment of dental caries and in the preservation and remineralisation of viable dentine tissue.
Asunto(s)
Caries Dental , Fluoruros , Compuestos de Plata , Humanos , Adolescente , Adulto Joven , Adulto , Caries Dental/tratamiento farmacológico , Pulpa Dental , Especies Reactivas de Oxígeno , Dentina , Yoduro de Potasio/uso terapéutico , Células MadreRESUMEN
Abstract Sporotrichosis is a subcutaneous mycosis caused by dimorphic fungi of the genus Sporothrix. The authors report a case of fixed cutaneous sporotrichosis with therapeutic failure after 18 months of itraconazole and terbinafine associated with cryosurgery. The patient was cured after the introduction of saturated potassium iodide solution. Sporothrix brasiliensis was the identified species, presenting a susceptibility profile to itraconazole and terbinafine. This fact suggests that therapeutic failure is probably related to the host-fungus interaction rather than drug resistance. It is possible that the immunomodulatory action of the saturated potassium iodide solution may have played an important role in curing this patient.
Asunto(s)
Esporotricosis/tratamiento farmacológico , Sporothrix , Yoduro de Potasio/uso terapéutico , Itraconazol , Antifúngicos/uso terapéuticoRESUMEN
Abstract: We report 73 cases of cutaneous sporotrichosis from the Community Dermatology program, at the central and mountain areas of the state of Guerrero, Mexico. A similar number of cases was found between children and adults, mostly peasants and school-age children with rural occupations. Upper limbs were the mostly affected and the predominant clinical form was lymphocutaneous (56.16%). All cultures corresponded to Sporothrix schenckii (sl). Treatment was done with potassium iodide in 54 patients, achieving clinical and mycological cure in all cases.
Asunto(s)
Humanos , Masculino , Femenino , Lactante , Preescolar , Niño , Adolescente , Adulto , Persona de Mediana Edad , Anciano , Adulto Joven , Esporotricosis/epidemiología , Yoduro de Potasio/uso terapéutico , Factores Socioeconómicos , Esporotricosis/diagnóstico , Esporotricosis/tratamiento farmacológico , México/epidemiologíaRESUMEN
Abstract Sporotrichosis is the most prevalent subcutaneous mycosis and is characterized by a subacute or chronic development of a cutaneous or subcutaneous nodular lesion. It is caused by the dimorphic fungus Sporothrix spp, which may manifest in different clinical forms. The disseminated cutaneous form is uncommon and is more likely to occur in immunocompromised patients. We report a 47-year-old male patient with multiple cutaneous and subcutaneous nodules. The patient was diagnosed with disseminated cutaneous sporotrichosis based on the isolation and identification of Sporothrix spp. The patient was treated with potassium iodide, which resulted in clinical improvement of the lesions.
Asunto(s)
Humanos , Masculino , Esporotricosis/diagnóstico , Alcoholismo/complicaciones , Yoduro de Potasio/uso terapéutico , Esporotricosis/complicaciones , Esporotricosis/tratamiento farmacológico , Persona de Mediana EdadRESUMEN
Introducción: La esporotricosis linfocutánea es una micosis subcutánea de evolución sub-aguda o crónica, que es más frecuente en adultos entre los 16 y 30 años de edad pero que también se presenta en la niñez, sobre todo en áreas rurales. Se caracteriza por nódulos que se reblandecen y luego se ulceran, lo cual constituye el chancro inicial. Dos o tres semanas después se observan nódulos eritematovioláceos, no dolorosos siguiendo el trayecto linfático regional. El diagnóstico definitivo se realiza al aislar el agente causal mediante cultivo. En nuestro país el tratamiento usual y eficaz sigue siendo el yoduro de potasio. Caso Clínico: Se presenta el caso de un paciente masculino de 2 años de edad, con dermatosis de 2 semanas de evolución con historia de trauma 2 semanas antes del inicio de las lesiones, caracterizada por úlcera costrosa en dorso de mano derecha con presencia de adenopatías blandas, no dolorosas siguiendo la cadena ganglionar de antebrazo y brazo derecho. Conclusiones: La esporotricosis puede presentarse a cualquier edad aún en niños tan pequeños como este paciente de 2 años. La solución saturada de yoduro de potasio es muy eficaz en el manejo de esta patología por lo que aunado a su bajo costo sigue siendo de elección en países en vías de desarrollo...
Asunto(s)
Humanos , Masculino , Niño , Esporotricosis/diagnóstico , Micosis/clasificación , Yoduro de Potasio/uso terapéutico , Dermatosis de la Mano/complicaciones , Úlcera Cutánea/diagnósticoRESUMEN
BACKGROUND: Sporotrichosis is a subacute or chronic disease caused by a dimorphic fungus, Sporothrix schenckii. The first and most traditional treatment is potassium iodide in satured solution (SSKI) used by DE BEURMANN in 1907. For its effectiveness, it is still used for cutaneous sporotrichosis. OBJECTIVE: To evaluate the treatment of cutaneous sporotrichosis with SSKI in relation to clinical cure, side effects, length of treatment and reactivation. METHODS: We conducted a retrospective analysis of medical records over a 24-year period (1981-2005). Patients of all ages who were treated in the hospital´s division of dermatology were included in the study providing that they had a positive culture of S. schenckii. Satured solution of potassium iodide (3 to 6g per day) was the treatment prescribed. For children, half of the dose was prescribed. RESULTS: The lymphocutaneous disease was prevalent, the cure rate was 94.7 percent, side effects were described in 5.5 percent of the cases, mean length of treatment was 3.5 months and possible reactivation was observed in 11.1 percent. CONCLUSION: SSKI is an effective drug, with many side effects, but with low frequency. Resolution was for maximum six months of treatment. SSKI has been found to be a very effective drug in this retrospective study of culture-proven cases of cutaneous and lymphocutaneous sporotrichosis. It should be used as first drug of choice especially in resource-limited settings.
FUNDAMENTOS: Esporotricose é doença subaguda ou crônica causada pelo fungo dimórfico Sporothrix schenckii. O primeiro e mais tradicional tratamento é o iodeto de potássio em solução saturada (SSKI) usado por De Beurmann em 1907. Por ser eficaz,ainda é muito utilizada no nosso meio para o tratamento da esporotricose cutânea. OBJETIVOS: Avaliar o tratamento da esporotricose cutânea com SSKI em relação à cura clínica, efeitos colaterais, tempo de tratamento e recidiva. MÉTODOS: A partir da revisão dos resultados de exames do laboratório de Micologia da Clínica de Dermatologia da Santa Casa de SP, durante 1981 a 2005, foram incluídos pacientes de qualquer idade com lesão cutânea sugestiva de esporotricose e cultura positiva para S. schenckii. Em todos pacientes o tratamento prescrito foi SSKI na dose de 3 a 6g/dia para adultos, por um período de até duas semanas após cura clínica. Em crianças foi utilizada a metade da dose. RESULTADOS: Houve predomínio da forma cutânea localizada, taxa de cura de 94,7 por cento, efeitos colaterais em 5,5 por cento, média de tempo de tratamento de 3,5 meses e 11,1 por cento de provável recidiva. CONCLUSÃO: A SSKI é eficaz, com diversos efeitos colaterais, porém de baixa frequência, permanecendo indicada para as formas cutâneas da esporotricose.
Asunto(s)
Adolescente , Adulto , Anciano , Niño , Preescolar , Femenino , Humanos , Lactante , Masculino , Persona de Mediana Edad , Adulto Joven , Antifúngicos/uso terapéutico , Yoduro de Potasio/uso terapéutico , Esporotricosis/tratamiento farmacológico , Recurrencia , Estudios Retrospectivos , Resultado del TratamientoRESUMEN
Se presenta un caso de esporotricosis linfocutánea de las extremidades tipo clásico. El diagnósdtico de certeza se hizo a través del cultivo; se logró la curación luego de 6 meses de tratamiento con toduro de potasio por vía bucal y termoterapia local con secuelas cicatrizales en el miembro afectado
Asunto(s)
Humanos , Femenino , Persona de Mediana Edad , Antifúngicos/uso terapéutico , Yoduro de Potasio/uso terapéutico , Esporotricosis/diagnóstico , Esporotricosis/terapia , Extremidades/patología , Hipertermia InducidaRESUMEN
A utilização do iodo antes de cirurgias de tireóide visa a redução do fluxo sanguíneo para a glândula e melhora da hemostasia. Para tentar elucidar o mecanismo pelo qual a vasoconstricção se instala, foi determinada a atividade colinesterásica em tireóides de ratos Wistar machos (240-250g de peso corporal), submetidos a uma sobrecarga oral de iodo pela oferta de solução aquosa de iodato de potássio (KIO 3 3µg/ml) como água de beber, por 3 e 7 dias; o grupo controle recebeu água durante o mesmo período. Ao final do tratamento os animais foram sacrificados e suas tireóides retiradas, limpas e pesadas; o rim direito e o lobo direito do fígado foram usados como controles da atividade colinesterásica. Foram preparados homogeneizados em tampão fosfato (pH=8,0), contendo 0,32M de sacarose, na concentração de 40mg de tecido/ml. Os ratos que receberam KIO 3 por 7 dias tiveram diminuição no peso da tireóide quando comparados aos controles (p<0,05), o mesmo não acontecendo aos 3 dias de tratamento. Aos 3 dias de tratamento, a atividade colinesterásica tireóidea foi de 5,38ñ0,36 nmol/min.mg para o grupo controle (n=12) e de 5,43ñ0,98 nmol/min.mg para o grupo tratado (n=11) (NS); valores bastante similares foram também encontrados com o tratamento de 7 dias (controles: 5,42ñ0,27 nmol/min.mg [n=8] e tratados: 5,63ñ0,88 nmol/min.mg [n=8]; NS). Nossos resultados sugerem que, a despeito da vasoconstricção, não há alteração da atividade colinesterásica na tireóide em resposta a sobrecarga oral de iodo.
Asunto(s)
Animales , Masculino , Ratas , Colinesterasas/metabolismo , Glándula Tiroides/enzimología , Yodo/farmacología , Hígado/enzimología , Glándula Tiroides/cirugía , Yoduro de Potasio/uso terapéutico , Yodo/administración & dosificación , Riñón/enzimología , Tamaño de los Órganos/efectos de los fármacos , Ratas WistarRESUMEN
Presentamos a tres pacientes afectados de esporotricosis linfangítico-nodular, con las características comunes en lo concerniente a la clínica y el laboratorio. Lo distintivo estaría que nuestra área geográfica es naturalmente seca y, durante muchos meses del año, fría, es decir, una zona no apta para el desarrollo del hongo Sporothrix schenckil. Uno de nuestros pacientes se infectó, aparentemente, debido a una herida punzante con una astilla de material plástico. Exhortamos a los clínicos y dermatólogos de nuestra región a pensar en la esporotricosis como diagnóstico diferencial etiológico de todas las úlceras y abscesos "fríos" que no curen con los tratamientos habituales y por lo tanto su evolución crónica
Asunto(s)
Humanos , Masculino , Adulto , Persona de Mediana Edad , Sporothrix/patogenicidad , Esporotricosis/diagnóstico , Argentina , Hipertermia Inducida , Itraconazol/uso terapéutico , Yoduro de Potasio/uso terapéutico , Sporothrix/aislamiento & purificación , Esporotricosis/clasificación , Esporotricosis/tratamiento farmacológicoAsunto(s)
Humanos , Antifúngicos/uso terapéutico , Dermatomicosis/tratamiento farmacológico , Antifúngicos/administración & dosificación , Cromoblastomicosis/tratamiento farmacológico , Hongos Mitospóricos , Hipertermia Inducida/estadística & datos numéricos , Micetoma/tratamiento farmacológico , Yoduro de Potasio/administración & dosificación , Yoduro de Potasio/uso terapéutico , Esporotricosis/tratamiento farmacológicoRESUMEN
El pioderma gangrenoso es una enfermedad inflamatoria infrecuente, caracterizada por la aparición de pápulas, pústulas, nódulos y ulceraciones necróticas, que frecuentemente está asociada a enfermedades sistemáticas. La evolución es crónica con recurrencias y resistencia a los distintos tratamientos. Presentamos dos casos de pioderma gangrenoso: un paciente con la forma clásica y otro con la forma granulomatosa superficial. Esta enfermedad requiere un estudio exhaustivo del paciente para lograr el diagnóstico correcto. Sugerimos la terapéutica apropiada, pero debido a que se desconoce la fisiopatogenia aquélla resulta muchas veces infructuosa
Asunto(s)
Humanos , Masculino , Femenino , Persona de Mediana Edad , Piodermia Gangrenosa/diagnóstico , Dapsona/uso terapéutico , Interferón-alfa/uso terapéutico , Minociclina/uso terapéutico , Yoduro de Potasio/uso terapéutico , Piodermia Gangrenosa/complicaciones , Piodermia Gangrenosa/tratamiento farmacológico , Sulfapiridina/uso terapéutico , Tacrolimus/uso terapéuticoRESUMEN
Os autores registram caso de zigomicose subcutânea em paciente do sexo feminino, com dois anos de idade, branca, natural de Porto Franco, Estado do Maranhäo - Brasil, provocada por Basidiobolus haptosporus. Os exames histopatológicos e micológicos confirmaram o diagnóstico. Em face da experiência adquirida com o tratamento desses doentes, indicam o iodeto de potássio como a droga de escolha para o tratamento dessa micose
Asunto(s)
Humanos , Femenino , Lactante , Administración Oral , Cara/patología , Yoduro de Potasio/uso terapéutico , Mucorales/aislamiento & purificación , Mucormicosis/tratamiento farmacológico , Mucormicosis/epidemiología , Pruebas CutáneasRESUMEN
Se estudió la acción inhibidora "in vitro" de los siguientes antisépticos: etil mercurio tiosalicilato de sodio, azida sódica, borato de sodio, yoduro de potasio, fenol y cloro, frente a cultivos de 5 cepas de Prototheca wickerhamii. La acción "in vitro" de estas drogas fue medida mediante el halo de inhibición que produjeron en los cultivos de Prototheca en medio de agar-miel de Sabouraud incubados a 28ºC. Los resultados obtenidos permitieron establecer que todas las cepas eran uniformemente susceptibles al etilmercurio tiosalicilato de sodio y a la azida sódica, la mayor parte fue inhibida por el yoduro de potasio, en tanto que, el borato de sodio, el fenol y el cloro resultaron inactivos en las diluciones utilizadas
Asunto(s)
Antiinfecciosos Locales , Eucariontes/efectos de los fármacos , Técnicas In Vitro , Prototheca/efectos de los fármacos , Azidas/uso terapéutico , Boratos/uso terapéutico , Cloro/uso terapéutico , Heces/microbiología , Leche/microbiología , Fenol/uso terapéutico , Yoduro de Potasio/uso terapéutico , Prototheca/aislamiento & purificación , Prototheca/patogenicidad , Saneamiento de Piscinas , Timerosal/uso terapéuticoRESUMEN
Neste artigo säo analisadas as três grandes modalidades terapêuticas do hipertireoidismo - o tratamento clínico, o radioiodo e a cirurgia -, discutindo-se detalhadamente cada uma delas, enfocando seus mecanismos de açäo, vantagens e desvantagens, principais indicaçöes e contra indicaçöes. A abordagem terapêutica também será analisada em grupos especiais como neonatos, crianças e adolescentes, gestantes e idosos
Asunto(s)
Humanos , Masculino , Femenino , Embarazo , Recién Nacido , Adulto , Anciano , Alprenolol/uso terapéutico , Carbimazol/uso terapéutico , Carteolol/uso terapéutico , Enfermedad de Graves/cirugía , Enfermedad de Graves/tratamiento farmacológico , Enfermedad de Graves/radioterapia , Hipertiroidismo/tratamiento farmacológico , Hipertiroidismo/radioterapia , Hipertiroidismo/cirugía , Propranolol/uso terapéutico , Ácido Yopanoico/uso terapéutico , Bocio/cirugía , Yoduro de Potasio/uso terapéutico , Yodo/uso terapéutico , Ipodato/uso terapéutico , Metimazol/uso terapéutico , Metoprolol/uso terapéutico , Nadolol/uso terapéutico , Propiltiouracilo/uso terapéutico , TiroidectomíaRESUMEN
Se realizo un ensayo clinico, a doble ciegas, de las pacientes diagnosticadas de cervicitis aguda en el Policlinico Comunitario Docente "Jorge Ruiz Ramirez"desde el 1ro. de enero de 1993 hasta el 31 de diciembre de 1993 y fueron atendidas en el consultorio medico No. 15. La muestra se selecciono segun la tabla de numeros aleatorios y se analizaron diferentes variables como: edad, sintomas y signos encontrados, principales microorganismos, evolucion clinica y respuesta al tratamiento. Se concluyo que la mayoria de las pacientes con cervicitis aguda estuvieron comprendidas entre las edades de 20 a 29 anos de edad, que el propoleo logro mejorar el dolor bajo vientre asociado con el sangramiento poscoito con mayor efectividad y rapidez que el lugol; asi como el prurito vaginal. Ademas, se encontro que el propoleo es muy efectivo en la moniliasis y la trichomoniasis vaginal con resultados significativos. Se logro la curacion del 84,9 por ciento de los pacientes con cervicitis aguda tratadas con propoleo, contra el 50,0 por ciento de las que se trataron con lugol.