Detalhe da pesquisa
1.
Tailored quinoline hybrids as promising COX-2/15-LOX dual inhibitors endowed with diverse safety profile: Design, synthesis, SAR, and histopathological study.
Bioorg Chem;
145: 107244, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38428284
2.
N- and s-substituted Pyrazolopyrimidines: A promising new class of potent c-Src kinase inhibitors with prominent antitumor activity.
Bioorg Chem;
145: 107228, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38422592
3.
Design, Synthesis, In Vitro, and In Silico Studies of New N5-Substituted-pyrazolo[3,4-d]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors.
Pharmaceuticals (Basel);
16(11)2023 Nov 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38004458
4.
Development of Novel Class of Phenylpyrazolo[3,4-d]pyrimidine-Based Analogs with Potent Anticancer Activity and Multitarget Enzyme Inhibition Supported by Docking Studies.
Int J Mol Sci;
24(19)2023 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37834474
5.
In vivo screening and toxicity studies of indolinone incorporated thiosemicarbazone, thiazole and piperidinosulfonyl moieties as anticonvulsant agents.
Bioorg Chem;
116: 105300, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34525393
6.
Design, Synthesis, biological Evaluation, and molecular docking studies of novel Pyrazolo[3,4-d]Pyrimidine derivative scaffolds as potent EGFR inhibitors and cell apoptosis inducers.
Bioorg Chem;
116: 105325, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34507234
7.
Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies.
Arch Pharm (Weinheim);
: e2100258, 2021 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-34467546
8.
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity.
Bioorg Med Chem;
42: 116266, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34126285
9.
Synthesis, Anticancer Screening of Some Novel Trimethoxy Quinazolines and VEGFR2, EGFR Tyrosine Kinase Inhibitors Assay; Molecular Docking Studies.
Molecules;
26(10)2021 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34069962
10.
In vivo and in vitro anti-inflammatory, antipyretic and ulcerogenic activities of pyridone and chromenopyridone derivatives, physicochemical and pharmacokinetic studies.
Bioorg Chem;
109: 104742, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33647742
11.
In vivo- and in silico-driven identification of novel synthetic quinoxalines as anticonvulsants and AMPA inhibitors.
Arch Pharm (Weinheim);
354(5): e2000449, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-33559320
12.
Design, synthesis, and molecular docking studies of new [1,2,4]triazolo[4,3-a]quinoxaline derivatives as potential A2B receptor antagonists.
Mol Divers;
25(1): 291-306, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32166485
13.
Unravelling the anticancer potency of 1,2,4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies.
Mol Divers;
25(1): 403-420, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32830299
14.
Synthesis, antimicrobial evaluation, DNA gyrase inhibition, and in silico pharmacokinetic studies of novel quinoline derivatives.
Arch Pharm (Weinheim);
354(2): e2000277, 2021 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-33078877
15.
Novel 1,2,4-triazole derivatives: Design, synthesis, anticancer evaluation, molecular docking, and pharmacokinetic profiling studies.
Arch Pharm (Weinheim);
353(12): e2000170, 2020 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-32893368
16.
Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects.
Bioorg Chem;
101: 104019, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32615465
17.
Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies.
Bioorg Chem;
100: 103899, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32454390
18.
Antimicrobial screening and pharmacokinetic profiling of novel phenyl-[1,2,4]triazolo[4,3-a]quinoxaline analogues targeting DHFR and E. coli DNA gyrase B.
Bioorg Chem;
96: 103656, 2020 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32062449
19.
Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents.
Mol Divers;
23(1): 165-181, 2019 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-30099687
20.
Design, synthesis and anticancer evaluation of 1H-pyrazolo[3,4-d]pyrimidine derivatives as potent EGFRWT and EGFRT790M inhibitors and apoptosis inducers.
Bioorg Chem;
80: 375-395, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29986185