Detalhe da pesquisa
1.
Vaccine value profile for Klebsiella pneumoniae.
Vaccine;
2024 Mar 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38503661
2.
The CARB-X Portfolio of Nontraditional Antibacterial Products.
ACS Infect Dis;
7(8): 2043-2049, 2021 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34346202
3.
Thienopyrimidinone Derivatives That Inhibit Bacterial tRNA (Guanine37-N1)-Methyltransferase (TrmD) by Restructuring the Active Site with a Tyrosine-Flipping Mechanism.
J Med Chem;
62(17): 7788-7805, 2019 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31442049
4.
A Novel Hexavalent Capsular Polysaccharide Conjugate Vaccine (GBS6) for the Prevention of Neonatal Group B Streptococcal Infections by Maternal Immunization.
J Infect Dis;
220(1): 105-115, 2019 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30778554
5.
Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.
Proc Natl Acad Sci U S A;
113(29): 8188-93, 2016 07 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-27382179
6.
Staphylococcus aureus Clumping Factor A Remains a Viable Vaccine Target for Prevention of S. aureus Infection.
mBio;
7(2): e00225, 2016 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26956591
7.
Markerless Escherichia coli rrn Deletion Strains for Genetic Determination of Ribosomal Binding Sites.
G3 (Bethesda);
5(12): 2555-7, 2015 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-26438293
8.
Structural Insights Lead to a Negamycin Analogue with Improved Antimicrobial Activity against Gram-Negative Pathogens.
ACS Med Chem Lett;
6(8): 930-5, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26288696
9.
Translating slow-binding inhibition kinetics into cellular and in vivo effects.
Nat Chem Biol;
11(6): 416-23, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25894085
10.
X-ray crystal structures of Escherichia coli RNA polymerase with switch region binding inhibitors enable rational design of squaramides with an improved fraction unbound to human plasma protein.
J Med Chem;
58(7): 3156-71, 2015 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25798859
11.
Pharmacokinetics of the natural antibiotic negamycin.
Xenobiotica;
45(7): 625-33, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25733027
12.
Illicit Transport via Dipeptide Transporter Dpp is Irrelevant to the Efficacy of Negamycin in Mouse Thigh Models of Escherichia coli Infection.
ACS Infect Dis;
1(5): 222-30, 2015 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27622650
13.
Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.
Proc Natl Acad Sci U S A;
111(46): 16274-9, 2014 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-25368144
14.
The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability.
J Biol Chem;
289(31): 21651-62, 2014 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24936059
15.
Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.
J Med Chem;
56(18): 7278-88, 2013 Sep 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-23981144
16.
Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides.
Bioorg Med Chem Lett;
22(23): 7019-23, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23099094
17.
Novel rapidly diversifiable antimicrobial RNA polymerase switch region inhibitors with confirmed mode of action in Haemophilus influenzae.
J Bacteriol;
194(20): 5504-12, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22843845
18.
Molecular determinants of AcrB-mediated bacterial efflux implications for drug discovery.
J Med Chem;
55(6): 2532-7, 2012 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22224562
19.
Antimicrobial Activity of Adenine-Based Inhibitors of NAD(+)-Dependent DNA Ligase.
ACS Med Chem Lett;
3(8): 663-7, 2012 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900527
20.
In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae.
J Biol Chem;
286(47): 40734-42, 2011 Nov 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21984832