Detalhe da pesquisa
1.
Nature-Inspired Gallinamides Are Potent Antischistosomal Agents: Inhibition of the Cathepsin B1 Protease Target and Binding Mode Analysis.
ACS Infect Dis;
2024 May 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38757505
2.
Development of subunit selective proteasome substrates for Schistosoma species.
bioRxiv;
2024 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38405969
3.
Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase Domain.
ACS Med Chem Lett;
13(11): 1715-1722, 2022 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-36385939
4.
EF24, a schistosomicidal curcumin analog: Insights from its synthesis and phenotypic, biochemical and cytotoxic activities.
Chem Biol Interact;
368: 110191, 2022 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36181831
5.
Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells facilitate egg extravasation.
PLoS Pathog;
18(3): e1010309, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35316298
6.
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation.
Eur J Med Chem;
226: 113823, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34536671
7.
Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.
J Med Chem;
64(13): 9404-9430, 2021 07 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34156862
8.
A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules.
ACS Infect Dis;
7(2): 406-420, 2021 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33434015
9.
Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro.
ACS Infect Dis;
7(5): 1089-1103, 2021 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33135408
10.
Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone.
J Antimicrob Chemother;
75(10): 2925-2932, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32617557
11.
Structure-Bioactivity Relationships of Lapatinib Derived Analogs against Schistosoma mansoni.
ACS Med Chem Lett;
11(3): 258-265, 2020 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32184954
12.
Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty.
Pharmaceuticals (Basel);
13(2)2020 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32028743
13.
The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni.
ACS Infect Dis;
5(10): 1802-1812, 2019 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31355632
14.
Bioactivity of Farnesyltransferase Inhibitors Against Entamoeba histolytica and Schistosoma mansoni.
Front Cell Infect Microbiol;
9: 180, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31192168
15.
Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development.
Dis Model Mech;
11(7)2018 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-29925529
16.
Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.
PLoS Negl Trop Dis;
11(7): e0005680, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28704396
17.
Biogenic amines and the control of neuromuscular signaling in schistosomes.
Invert Neurosci;
12(1): 13-28, 2012 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-22526557
18.
A novel G protein-coupled receptor of Schistosoma mansoni (SmGPR-3) is activated by dopamine and is widely expressed in the nervous system.
PLoS Negl Trop Dis;
6(2): e1523, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22389736