Detalhe da pesquisa
1.
Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease.
Transl Neurodegener;
13(1): 25, 2024 May 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38773569
2.
Neuroprotection of Cholinergic Neurons with a Tau Aggregation Inhibitor and Rivastigmine in an Alzheimer's-like Tauopathy Mouse Model.
Cells;
13(7)2024 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38607082
3.
Hydromethylthionine rescues synaptic SNARE proteins in a mouse model of tauopathies: Interference by cholinesterase inhibitors.
Brain Res Bull;
212: 110955, 2024 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38677558
4.
LETC inhibits α-Syn aggregation and ameliorates motor deficiencies in the L62 mouse model of synucleinopathy.
Eur J Pharmacol;
970: 176505, 2024 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38503400
5.
Assays for the Screening and Characterization of Tau Aggregation Inhibitors.
Methods Mol Biol;
2754: 93-104, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38512662
6.
Solubility of α-synuclein species in the L62 mouse model of synucleinopathy.
Sci Rep;
14(1): 6239, 2024 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38486089
7.
A Meta-Analysis on Presynaptic Changes in Alzheimer's Disease.
J Alzheimers Dis;
97(1): 145-162, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38073390
8.
Exploring the Anti-Hypoxaemia Effect of Hydromethylthionine: A Prospective Study of Phase 3 Clinical Trial Participants.
Int J Mol Sci;
24(18)2023 Sep 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37762050
9.
Mitochondrial Effects of Hydromethylthionine, Rivastigmine and Memantine in Tau-Transgenic Mice.
Int J Mol Sci;
24(13)2023 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37445987
10.
Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis.
Cells;
12(8)2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37190093
11.
An Additive-Free Model for Tau Self-Assembly.
Methods Mol Biol;
2551: 163-188, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36310203
12.
Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391).
Front Neurosci;
16: 988074, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36570831
13.
Dityrosine Cross-links are Present in Alzheimer's Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297-391) In Vitro.
J Mol Biol;
434(19): 167785, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35961386
14.
Glutamatergic transmission and receptor expression in the synucleinopathy h-α-synL62 mouse model: Effects of hydromethylthionine.
Cell Signal;
97: 110386, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35709886
15.
HMTM-Mediated Enhancement of Brain Bioenergetics in a Mouse Tauopathy Model Is Blocked by Chronic Administration of Rivastigmine.
Biomedicines;
10(4)2022 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35453617
16.
Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine.
J Neurochem;
160(2): 172-184, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34855998
17.
Degeneration of basal and limbic networks is a core feature of behavioural variant frontotemporal dementia.
Brain Commun;
3(4): fcab241, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34939031
18.
Proteomic Analysis of Hydromethylthionine in the Line 66 Model of Frontotemporal Dementia Demonstrates Actions on Tau-Dependent and Tau-Independent Networks.
Cells;
10(8)2021 08 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34440931
19.
Long-Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier.
J Alzheimers Dis;
83(3): 1017-1023, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34366349
20.
Oxidative Stress Conditions Result in Trapping of PHF-Core Tau (297-391) Intermediates.
Cells;
10(3)2021 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33809978