Pesquisa | Portal Regional da BVS

1.

A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease.

Horne, G A; Stobo, J; Kelly, C; Mukhopadhyay, A; Latif, A L; Dixon-Hughes, J; McMahon, L; Cony-Makhoul, P; Byrne, J; Smith, G; Koschmieder, S; BrÜmmendorf, T H; Schafhausen, P; Gallipoli, P; Thomson, F; Cong, W; Clark, R E; Milojkovic, D; Helgason, G V; Foroni, L; Nicolini, F E; Holyoake, T L; Copland, M.

Leukemia; 34(7): 1775-1786, 2020 07.

Artigo em Inglês | MEDLINE | ID: mdl-31925317

2.

Mtss1 is a critical epigenetically regulated tumor suppressor in CML.

Schemionek, M; Herrmann, O; Reher, M M; Chatain, N; Schubert, C; Costa, I G; Hänzelmann, S; Gusmao, E G; Kintsler, S; Braunschweig, T; Hamilton, A; Helgason, G V; Copland, M; Schwab, A; Müller-Tidow, C; Li, S; Holyoake, T L; Brümmendorf, T H; Koschmieder, S.

Leukemia; 30(4): 823-32, 2016 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-26621336

3.

Dual glutathione-S-transferase-Î¸1 and -µ1 gene deletions determine imatinib failure in chronic myeloid leukemia.

Davies, A; Giannoudis, A; Zhang, J E; Austin, G; Wang, L; Holyoake, T L; Müller, M C; Foroni, L; Kottaridis, P D; Pirmohamed, M; Clark, R E.

Clin Pharmacol Ther; 96(6): 694-703, 2014 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-25188725

4.

Synergistic effects of proteasome inhibitor carfilzomib in combination with tyrosine kinase inhibitors in imatinib-sensitive and -resistant chronic myeloid leukemia models.

Crawford, L J; Chan, E T; Aujay, M; Holyoake, T L; Melo, J V; Jorgensen, H G; Suresh, S; Walker, B; Irvine, A E.

Oncogenesis; 3: e90, 2014 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-24590311

5.

Targeting survival pathways in chronic myeloid leukaemia stem cells.

Sinclair, A; Latif, A L; Holyoake, T L.

Br J Pharmacol; 169(8): 1693-707, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23517124

6.

A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.

Griaud, F; Pierce, A; Gonzalez Sanchez, M B; Scott, M; Abraham, S A; Holyoake, T L; Tran, D D H; Tamura, T; Whetton, A D.

Leukemia; 27(4): 932-40, 2013 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-23032722

7.

Expression of p89(c-Mybex9b), an alternatively spliced form of c-Myb, is required for proliferation and survival of p210BCR/ABL-expressing cells.

Manzotti, G; Mariani, S A; Corradini, F; Bussolari, R; Cesi, V; Vergalli, J; Ferrari-Amorotti, G; Fragliasso, V; Soliera, A R; Cattelani, S; Raschellà, G; Holyoake, T L; Calabretta, B.

Blood Cancer J; 2(5): e71, 2012 May.

Artigo em Inglês | MEDLINE | ID: mdl-22829973

8.

Smouldering systemic mastocytosis presenting with cryptic life-threatening crises: case report and literature review.

Shah, M; Holyoake, T L; Jackson, B; Drummond, M.

Scott Med J; 57(1): 60, 2012 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-22408224

9.

Gfi-1 inhibits proliferation and colony formation of p210BCR/ABL-expressing cells via transcriptional repression of STAT 5 and Mcl-1.

Soliera, A R; Mariani, S A; Audia, A; Lidonnici, M R; Addya, S; Ferrari-Amorotti, G; Cattelani, S; Manzotti, G; Fragliasso, V; Peterson, L; Perini, G; Holyoake, T L; Calabretta, B.

Leukemia; 26(7): 1555-63, 2012 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-22285998

10.

The MEK inhibitor PD184352 enhances BMS-214662-induced apoptosis in CD34+ CML stem/progenitor cells.

Pellicano, F; Simara, P; Sinclair, A; Helgason, G V; Copland, M; Grant, S; Holyoake, T L.

Leukemia; 25(7): 1159-67, 2011 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-21483442

11.

Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells.

Allan, E K; Holyoake, T L; Craig, A R; Jørgensen, H G.

Leukemia; 25(6): 985-94, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21468038

12.

Nilotinib concentration in cell lines and primary CD34(+) chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters.

Davies, A; Jordanides, N E; Giannoudis, A; Lucas, C M; Hatziieremia, S; Harris, R J; Jørgensen, H G; Holyoake, T L; Pirmohamed, M; Clark, R E; Mountford, J C.

Leukemia; 23(11): 1999-2006, 2009 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-19710702

13.

A pilot study of continuous imatinib vs pulsed imatinib with or without G-CSF in CML patients who have achieved a complete cytogenetic response.

Drummond, M W; Heaney, N; Kaeda, J; Nicolini, F E; Clark, R E; Wilson, G; Shepherd, P; Tighe, J; McLintock, L; Hughes, T; Holyoake, T L.

Leukemia; 23(6): 1199-201, 2009 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-19262595

14.

Nuclear entrapment of BCR-ABL by combining imatinib mesylate with leptomycin B does not eliminate CD34+ chronic myeloid leukaemia cells.

Allan, E K; Hamilton, A; Hatziieremia, S; Zhou, P; Jørgensen, H G; Vigneri, P; Holyoake, T L.

Leukemia; 23(5): 1006-8, 2009 May.

Artigo em Inglês | MEDLINE | ID: mdl-19151780

15.

Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors.

Konig, H; Holtz, M; Modi, H; Manley, P; Holyoake, T L; Forman, S J; Bhatia, R.

Leukemia; 22(4): 748-55, 2008 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-18273048

16.

Characterization of cancer stem cells in chronic myeloid leukaemia.

Jørgensen, H G; Holyoake, T L.

Biochem Soc Trans; 35(Pt 5): 1347-51, 2007 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-17956348

17.

What is new in chronic myeloid leukaemia?

Heaney, N B; Holyoake, T L.

Scott Med J; 52(1): 36-41; quiz 42, 58, 2007 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-17373424

18.

Human neutrophil elastase is not a target for therapy in chronic myeloid leukaemia.

Allan, E K; Holyoake, T L; Jørgensen, H G.

Leukemia; 20(11): 2054-5, 2006 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-17008889

19.

Immature monocytes from G-CSF-mobilized peripheral blood stem cell collections carry surface-bound IL-10 and have the potential to modulate alloreactivity.

Fraser, A R; Cook, G; Franklin, I M; Templeton, J G; Campbell, M; Holyoake, T L; Campbell, J D M.

J Leukoc Biol; 80(4): 862-9, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-16895973

20.

Management of chronic myeloid leukaemia in relapse following donor lymphocyte infusion induced remission: a retrospective study of the Clinical Trials Committee of the British Society of Blood & Marrow Transplantation (BSBMT).

Cummins, M; Cwynarski, K; Marktel, S; Dazzi, F; Cavenagh, J; Clark, R E; Holyoake, T L; Milligan, D; Parker, A; Russell, N H; Marks, D I.

Bone Marrow Transplant; 36(12): 1065-9, 2005 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-16247434

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