Detalhe da pesquisa
1.
Author Correction: A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells.
Sci Rep;
12(1): 17185, 2022 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36229506
2.
A quantitative high-throughput screen identifies compounds that lower expression of the SCA2-and ALS-associated gene ATXN2.
J Biol Chem;
298(8): 102228, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35787375
3.
Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.
J Med Chem;
65(12): 8303-8331, 2022 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35696646
4.
A platform of assays for the discovery of anti-Zika small-molecules with activity in a 3D-bioprinted outer-blood-retina model.
PLoS One;
17(1): e0261821, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35041689
5.
NCATS Inxight Drugs: a comprehensive and curated portal for translational research.
Nucleic Acids Res;
50(D1): D1307-D1316, 2022 01 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34648031
6.
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2.
Bioorg Med Chem;
46: 116349, 2021 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34500187
7.
The AKT modulator A-443654 reduces α-synuclein expression and normalizes ER stress and autophagy.
J Biol Chem;
297(4): 101191, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34520759
8.
Identification of Small Molecule Inhibitors of a Mir155 Transcriptional Reporter in Th17 Cells.
Sci Rep;
11(1): 11498, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34075120
9.
FEN1 Blockade for Platinum Chemo-Sensitization and Synthetic Lethality in Epithelial Ovarian Cancers.
Cancers (Basel);
13(8)2021 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33919707
10.
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell Rep;
35(4): 109040, 2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33910017
11.
Discovery and Optimization of 2H-1λ2-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
J Med Chem;
64(8): 4913-4946, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33822623
12.
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett;
41: 127974, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771585
13.
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Sci Rep;
11(1): 2121, 2021 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483532
14.
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Proc Natl Acad Sci U S A;
117(49): 31365-31375, 2020 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33229545
15.
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
J Med Chem;
63(19): 10984-11011, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902275
16.
Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors.
ACS Comb Sci;
22(8): 422-432, 2020 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32525297
17.
Identification of Small Molecule Enhancers of Immunotherapy for Melanoma.
Sci Rep;
10(1): 5688, 2020 03 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-32231230
18.
A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells.
Sci Rep;
10(1): 4203, 2020 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32144367
19.
Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer.
Cancer Res;
80(10): 1914-1926, 2020 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32193286
20.
Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells.
Sci Rep;
10(1): 3766, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32111885