Detalhe da pesquisa
1.
Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.
Arterioscler Thromb Vasc Biol;
43(10): 1808-1817, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37345522
2.
CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia.
Biochem Biophys Res Commun;
590: 49-54, 2022 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34971957
3.
A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.
Drug Dev Res;
82(8): 1235-1246, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34075610
4.
Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett;
41: 127974, 2021 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33771585
5.
Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites.
Sci Rep;
11(1): 2121, 2021 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33483532
6.
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
J Med Chem;
63(19): 10984-11011, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902275
7.
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Cell Rep;
30(6): 1798-1810.e4, 2020 02 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32049011
8.
Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.
Bioorg Med Chem Lett;
29(10): 1220-1226, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30905542
9.
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.
Cancer Cell;
35(2): 330-332, 2019 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30753830
10.
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).
PLoS One;
14(1): e0210525, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30625228
11.
Predicting Novel Therapies and Targets: Regulation of Notch3 by the Bromodomain Protein BRD4.
Mol Cancer Ther;
18(2): 421-436, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30420565
12.
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.
Cancer Cell;
34(6): 939-953.e9, 2018 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30472020
13.
Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol.
Elife;
72018 11 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30479275
14.
Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
J Med Chem;
61(23): 10588-10601, 2018 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30392349
15.
Discovery and lead identification of quinazoline-based BRD4 inhibitors.
Bioorg Med Chem Lett;
28(21): 3483-3488, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30268702
16.
KDM5 histone demethylases repress immune response via suppression of STING.
PLoS Biol;
16(8): e2006134, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30080846
17.
Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats.
Pain;
159(12): 2620-2629, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30130298
18.
Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.
PLoS One;
13(5): e0197292, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29763427
19.
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
J Med Chem;
61(11): 4883-4903, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29767973
20.
DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1.
Cell Death Dis;
9(5): 561, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29752431