Detalhe da pesquisa
1.
Synthesis, Cytotoxicity, and Photophysical Investigations of 2-Amino-4,6-diphenylnicotinonitriles: An Experimental and Theoretical Study.
Molecules;
29(8)2024 Apr 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38675628
2.
Discovery of New Pyrrolo[2,3-d]pyrimidine Derivatives as Potential Multi-Targeted Kinase Inhibitors and Apoptosis Inducers.
Pharmaceuticals (Basel);
16(9)2023 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37765132
3.
Editorial: Small organic molecules with anticancer activity.
Front Chem;
11: 1254312, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37681208
4.
Synthesis and SARs study of novel spiro-oxindoles as potent antiproliferative agents with CDK-2 inhibitory activities.
Arch Pharm (Weinheim);
356(8): e2300185, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37253118
5.
In Vitro Identification of Potential Metabolites of Plinabulin (NPI 2358) in Hepatic Preparations Using Liquid Chromatography-Ion Trap Mass Spectrometry.
ACS Omega;
7(25): 21465-21472, 2022 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35785266
6.
Detection and characterization of simvastatin and its metabolites in rat tissues and biological fluids using MALDI high resolution mass spectrometry approach.
Sci Rep;
12(1): 4757, 2022 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35306510
7.
Synthesis and Photophysical Properties of Fluorescein Esters as Potential Organic Semiconductor Materials.
J Fluoresc;
31(5): 1489-1502, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34287764
8.
Galeon: A Biologically Active Molecule with In Silico Metabolite Prediction, In Vitro Metabolic Profiling in Rat Liver Microsomes, and In Silico Binding Mechanisms with CYP450 Isoforms.
Molecules;
25(24)2020 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33322201
9.
Experimental and computational evaluation of kolliphor RH 40 as a new fluorescence enhancer in development of a micellar-based spectrofluorimetric method for determination of lapatinib in tablets and urine.
PLoS One;
15(12): e0239918, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33270656
10.
A Series of Isatin-Hydrazones with Cytotoxic Activity and CDK2 Kinase Inhibitory Activity: A Potential Type II ATP Competitive Inhibitor.
Molecules;
25(19)2020 Sep 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32992673
11.
Synthesis, Biological Evaluation and Molecular Docking Study of Cyclic Diarylheptanoids as Potential Anticancer Therapeutics.
Anticancer Agents Med Chem;
20(4): 464-475, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31763968
12.
In-vitro metabolic profiling study of potential topoisomerase inhibitors 'pyrazolines' in RLMs by mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci;
1114-1115: 125-133, 2019 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30953840
13.
In vitro investigation of metabolic profiling of newly developed topoisomerase inhibitors (ethyl fluorescein hydrazones, EtFLHs) in RLMs by LC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci;
1054: 93-104, 2017 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28433551
14.
In vitro Investigation of Metabolic Profiling of a Potent Topoisomerase Inhibitors Fluorescein Hydrazones (FLHs) in RLMs by LC-MS/MS.
J Chromatogr B Analyt Technol Biomed Life Sci;
1054: 27-35, 2017 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28415021
15.
Fluorescein hydrazones: A series of novel non-intercalative topoisomerase IIα catalytic inhibitors induce G1 arrest and apoptosis in breast and colon cancer cells.
Eur J Med Chem;
125: 49-67, 2017 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27654394
16.
Design, synthesis, topoisomerase I & II inhibitory activity, antiproliferative activity, and structure-activity relationship study of pyrazoline derivatives: An ATP-competitive human topoisomerase IIα catalytic inhibitor.
Bioorg Med Chem;
24(8): 1898-908, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26988802
17.
A concise synthesis and evaluation of new malonamide derivatives as potential α-glucosidase inhibitors.
Bioorg Med Chem;
24(8): 1675-82, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26972921
18.
Spatial localisation of curcumin and rapid screening of the chemical compositions of turmeric rhizomes (Curcuma longa Linn.) using Direct Analysis in Real Time-Mass Spectrometry (DART-MS).
Food Chem;
173: 489-94, 2015 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25466050
19.
Fluorescein hydrazones as novel nonintercalative topoisomerase catalytic inhibitors with low DNA toxicity.
J Med Chem;
57(21): 9139-51, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25333701
20.
Dasatinib.
Profiles Drug Subst Excip Relat Methodol;
39: 205-37, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24794907