Pesquisa | Portal Regional da BVS

1.

Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness.

Lin, Chun-Pu; Levy, Pierre L; Alflen, Astrid; Apriamashvili, Georgi; Ligtenberg, Maarten A; Vredevoogd, David W; Bleijerveld, Onno B; Alkan, Ferhat; Malka, Yuval; Hoekman, Liesbeth; Markovits, Ettai; George, Austin; Traets, Joleen J H; Krijgsman, Oscar; van Vliet, Alex; Pozniak, Joanna; Pulido-Vicuña, Carlos Ariel; de Bruijn, Beaunelle; van Hal-van Veen, Susan E; Boshuizen, Julia; van der Helm, Pim W; Díaz-Gómez, Judit; Warda, Hamdy; Behrens, Leonie M; Mardesic, Paula; Dehni, Bilal; Visser, Nils L; Marine, Jean-Christophe; Markel, Gal; Faller, William J; Altelaar, Maarten; Agami, Reuven; Besser, Michal J; Peeper, Daniel S.

Cancer Cell; 42(4): 623-645.e10, 2024 Apr 08.

Artigo em Inglês | MEDLINE | ID: mdl-38490212

2.

Heterogeneity in functional genetic screens: friend or foe?

Vredevoogd, David W; Peeper, Daniel S.

Front Immunol; 14: 1162706, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37398651

3.

Author Correction: Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

Boshuizen, Julia; Vredevoogd, David W; Krijgsman, Oscar; Ligtenberg, Maarten A; Blankenstein, Stephanie; de Bruijn, Beaunelle; Frederick, Dennie T; Kenski, Juliana C N; Parren, Mara; Brüggemann, Marieke; Madu, Max F; Rozeman, Elisa A; Song, Ji-Ying; Horlings, Hugo M; Blank, Christian U; van Akkooi, Alexander C J; Flaherty, Keith T; Boland, Genevieve M; Peeper, Daniel S.

Nat Commun; 14(1): 672, 2023 Feb 07.

Artigo em Inglês | MEDLINE | ID: mdl-36750559

4.

An adverse tumor-protective effect of IDO1 inhibition.

Kenski, Juliana C N; Huang, Xinyao; Vredevoogd, David W; de Bruijn, Beaunelle; Traets, Joleen J H; Ibáñez-Molero, Sofía; Schieven, Sebastiaan M; van Vliet, Alex; Krijgsman, Oscar; Kuilman, Thomas; Pozniak, Joanna; Loayza-Puch, Fabricio; Terry, Alexandra M; Müller, Judith; Logtenberg, Meike E W; de Bruijn, Marjolein; Levy, Pierre; Körner, Pierre-René; Goding, Colin R; Schumacher, Ton N; Marine, Jean-Christophe; Agami, Reuven; Peeper, Daniel S.

Cell Rep Med; 4(2): 100941, 2023 02 21.

Artigo em Inglês | MEDLINE | ID: mdl-36812891

5.

TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling.

Lin, Chun-Pu; Traets, Joleen J H; Vredevoogd, David W; Visser, Nils L; Peeper, Daniel S.

EMBO J; 42(5): e111614, 2023 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-36715448

6.

RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells.

Zhang, Zhengkui; Kong, Xiangjun; Ligtenberg, Maarten A; van Hal-van Veen, Susan E; Visser, Nils L; de Bruijn, Beaunelle; Stecker, Kelly; van der Helm, Pim W; Kuilman, Thomas; Hoefsmit, Esmée P; Vredevoogd, David W; Apriamashvili, Georgi; Baars, Beau; Voest, Emile E; Klarenbeek, Sjoerd; Altelaar, Maarten; Peeper, Daniel S.

Cell Rep Med; 3(6): 100655, 2022 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-35688159

7.

Ubiquitin ligase STUB1 destabilizes IFNÎ³-receptor complex to suppress tumor IFNÎ³ signaling.

Apriamashvili, Georgi; Vredevoogd, David W; Krijgsman, Oscar; Bleijerveld, Onno B; Ligtenberg, Maarten A; de Bruijn, Beaunelle; Boshuizen, Julia; Traets, Joleen J H; D'Empaire Altimari, Daniela; van Vliet, Alex; Lin, Chun-Pu; Visser, Nils L; Londino, James D; Sanchez-Hodge, Rebekah; Oswalt, Leah E; Altinok, Selin; Schisler, Jonathan C; Altelaar, Maarten; Peeper, Daniel S.

Nat Commun; 13(1): 1923, 2022 04 08.

Artigo em Inglês | MEDLINE | ID: mdl-35395848

8.

Enabling oncogenes.

Vredevoogd, David W; Peeper, Daniel S.

Science; 373(6559): 1088-1089, 2021 Sep 03.

Artigo em Inglês | MEDLINE | ID: mdl-34516853

9.

Predictive Immune-Checkpoint Blockade Classifiers Identify Tumors Responding to Inhibition of PD-1 and/or CTLA-4.

Krijgsman, Oscar; Kemper, Kristel; Boshuizen, Julia; Vredevoogd, David W; Rozeman, Elisa A; Ibanez Molero, Sofia; de Bruijn, Beaunelle; Cornelissen-Steijger, Paulien; Shahrabi, Aida; Del Castillo Velasco-Herrera, Martin; Song, Ji-Ying; Ligtenberg, Maarten A; Kluin, Roelof J C; Kuilman, Thomas; Ross-Macdonald, Petra; Haanen, John B A G; Adams, David J; Blank, Christian U; Peeper, Daniel S.

Clin Cancer Res; 27(19): 5389-5400, 2021 10 01.

Artigo em Inglês | MEDLINE | ID: mdl-34230026

10.

Cooperative Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade.

Boshuizen, Julia; Pencheva, Nora; Krijgsman, Oscar; Altimari, Daniela D'Empaire; Castro, Patricia Garrido; de Bruijn, Beaunelle; Ligtenberg, Maarten A; Gresnigt-Van den Heuvel, Elke; Vredevoogd, David W; Song, Ji-Ying; Visser, Nils; Apriamashvili, Georgi; Janmaat, Maarten L; Plantinga, Theo S; Franken, Patrick; Houtkamp, Mischa; Lingnau, Andreas; Jure-Kunkel, Maria; Peeper, Daniel S.

Cancer Res; 81(7): 1775-1787, 2021 04 01.

Artigo em Inglês | MEDLINE | ID: mdl-33531370

11.

Labeling and tracking of immune cells in ex vivo human skin.

Dijkgraaf, Feline E; Toebes, Mireille; Hoogenboezem, Mark; Mertz, Marjolijn; Vredevoogd, David W; Matos, Tiago R; Teunissen, Marcel B M; Luiten, Rosalie M; Schumacher, Ton N.

Nat Protoc; 16(2): 791-811, 2021 02.

Artigo em Inglês | MEDLINE | ID: mdl-33349704

12.

Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

Boshuizen, Julia; Vredevoogd, David W; Krijgsman, Oscar; Ligtenberg, Maarten A; Blankenstein, Stephanie; de Bruijn, Beaunelle; Frederick, Dennie T; Kenski, Juliana C N; Parren, Mara; Brüggemann, Marieke; Madu, Max F; Rozeman, Elisa A; Song, Ji-Ying; Horlings, Hugo M; Blank, Christian U; van Akkooi, Alexander C J; Flaherty, Keith T; Boland, Genevieve M; Peeper, Daniel S.

Nat Commun; 11(1): 3946, 2020 08 07.

Artigo em Inglês | MEDLINE | ID: mdl-32770055

13.

A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool.

Kok, Lianne; Dijkgraaf, Feline E; Urbanus, Jos; Bresser, Kaspar; Vredevoogd, David W; Cardoso, Rebeca F; Perié, Leïla; Beltman, Joost B; Schumacher, Ton N.

J Exp Med; 217(10)2020 10 05.

Artigo em Inglês | MEDLINE | ID: mdl-32728699

14.

Author Correction: Tissue patrol by resident memory CD8⁺ T cells in human skin.

Dijkgraaf, Feline E; Matos, Tiago R; Hoogenboezem, Mark; Toebes, Mireille; Vredevoogd, David W; Mertz, Marjolijn; van den Broek, Bram; Song, Ji-Ying; Teunissen, Marcel B M; Luiten, Rosalie M; Beltman, Joost B; Schumacher, Ton N.

Nat Immunol; 21(6): 696, 2020 06.

Artigo em Inglês | MEDLINE | ID: mdl-32210390

15.

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

Vredevoogd, David W; Kuilman, Thomas; Ligtenberg, Maarten A; Boshuizen, Julia; Stecker, Kelly E; de Bruijn, Beaunelle; Krijgsman, Oscar; Huang, Xinyao; Kenski, Juliana C N; Lacroix, Ruben; Mezzadra, Riccardo; Gomez-Eerland, Raquel; Yildiz, Mete; Dagidir, Ilknur; Apriamashvili, Georgi; Zandhuis, Nordin; van der Noort, Vincent; Visser, Nils L; Blank, Christian U; Altelaar, Maarten; Schumacher, Ton N; Peeper, Daniel S.

Cell; 180(2): 404-405, 2020 Jan 23.

Artigo em Inglês | MEDLINE | ID: mdl-31978349

16.

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.

Nagler, Adi; Vredevoogd, David W; Alon, Michal; Cheng, Phil F; Trabish, Sophie; Kalaora, Shelly; Arafeh, Rand; Goldin, Victoria; Levesque, Mitchell P; Peeper, Daniel S; Samuels, Yardena.

Pigment Cell Melanoma Res; 33(2): 334-344, 2020 03.

Artigo em Inglês | MEDLINE | ID: mdl-31549767

17.

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

Vredevoogd, David W; Kuilman, Thomas; Ligtenberg, Maarten A; Boshuizen, Julia; Stecker, Kelly E; de Bruijn, Beaunelle; Krijgsman, Oscar; Huang, Xinyao; Kenski, Juliana C N; Lacroix, Ruben; Mezzadra, Riccardo; Gomez-Eerland, Raquel; Yildiz, Mete; Dagidir, Ilknur; Apriamashvili, Georgi; Zandhuis, Nordin; van der Noort, Vincent; Visser, Nils L; Blank, Christian U; Altelaar, Maarten; Schumacher, Ton N; Peeper, Daniel S.

Cell; 178(3): 585-599.e15, 2019 07 25.

Artigo em Inglês | MEDLINE | ID: mdl-31303383

18.

Tissue patrol by resident memory CD8⁺ T cells in human skin.

Dijkgraaf, Feline E; Matos, Tiago R; Hoogenboezem, Mark; Toebes, Mireille; Vredevoogd, David W; Mertz, Marjolijn; van den Broek, Bram; Song, Ji-Ying; Teunissen, Marcel B M; Luiten, Rosalie M; Beltman, Joost B; Schumacher, Ton N.

Nat Immunol; 20(6): 756-764, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-31110315

19.

In vitro-Induced Human IL-10⁺ B Cells Do Not Show a Subset-Defining Marker Signature and Plastically Co-express IL-10 With Pro-Inflammatory Cytokines.

Lighaam, Laura C; Unger, Peter-Paul A; Vredevoogd, David W; Verhoeven, Dorit; Vermeulen, Ellen; Turksma, Annelies W; Ten Brinke, Anja; Rispens, Theo; van Ham, S Marieke.

Front Immunol; 9: 1913, 2018.

Artigo em Inglês | MEDLINE | ID: mdl-30258433

20.

Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.

Boshuizen, Julia; Koopman, Louise A; Krijgsman, Oscar; Shahrabi, Aida; van den Heuvel, Elke Gresnigt-; Ligtenberg, Maarten A; Vredevoogd, David W; Kemper, Kristel; Kuilman, Thomas; Song, Ji-Ying; Pencheva, Nora; Mortensen, Jens Thing; Foppen, Marnix Geukes; Rozeman, Elisa A; Blank, Christian U; Janmaat, Maarten L; Satijn, David; Breij, Esther C W; Peeper, Daniel S; Parren, Paul W H I.

Nat Med; 24(2): 203-212, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29334371

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Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness.

Heterogeneity in functional genetic screens: friend or foe?

Author Correction: Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

An adverse tumor-protective effect of IDO1 inhibition.

TSC2 regulates tumor susceptibility to TRAIL-mediated T-cell killing by orchestrating mTOR signaling.

RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells.

Ubiquitin ligase STUB1 destabilizes IFNÎ³-receptor complex to suppress tumor IFNÎ³ signaling.

Enabling oncogenes.

Predictive Immune-Checkpoint Blockade Classifiers Identify Tumors Responding to Inhibition of PD-1 and/or CTLA-4.

Cooperative Targeting of Immunotherapy-Resistant Melanoma and Lung Cancer by an AXL-Targeting Antibody-Drug Conjugate and Immune Checkpoint Blockade.

Labeling and tracking of immune cells in ex vivo human skin.

Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

A committed tissue-resident memory T cell precursor within the circulating CD8+ effector T cell pool.

Author Correction: Tissue patrol by resident memory CD8⁺ T cells in human skin.

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

A genome-wide CRISPR screen identifies FBXO42 involvement in resistance toward MEK inhibition in NRAS-mutant melanoma.

Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold.

Tissue patrol by resident memory CD8⁺ T cells in human skin.

In vitro-Induced Human IL-10⁺ B Cells Do Not Show a Subset-Defining Marker Signature and Plastically Co-express IL-10 With Pro-Inflammatory Cytokines.

Cooperative targeting of melanoma heterogeneity with an AXL antibody-drug conjugate and BRAF/MEK inhibitors.