Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A
Rev. Soc. Bras. Med. Trop
; 52: e20180001, 2019. tab, graf
Article
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| LILACS
| ID: biblio-1041589
Biblioteca responsable:
BR1.1
ABSTRACT
Abstract INTRODUCTION:
Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival.METHODS:
Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host.RESULTS:
Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture.CONCLUSIONS:
These findings highlight the role of host stress in the virulence of S. epidermidis.Palabras clave
Texto completo:
1
Base de datos:
LILACS
Asunto principal:
Staphylococcus epidermidis
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Virulencia
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Biopelículas
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Medios de Cultivo
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Interacciones Microbiota-Huesped
Límite:
Humans
Idioma:
En
Revista:
Rev. Soc. Bras. Med. Trop
Asunto de la revista:
MEDICINA TROPICAL
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil