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The SREBP (Sterol Regulatory Element-Binding Protein) pathway: a regulatory bridge between carotenogenesis and sterol biosynthesis in the carotenogenic yeast Xanthophyllomyces dendrorhous
Gómez, Melissa; Baeza, Marcelo; Cifuentes, Víctor; Alcaíno, Jennifer.
Afiliación
  • Gómez, Melissa; Universidad de Chile. Facultad de Ciencias. Departamento de Ciencias Ecológicas. Santiago. CL
  • Baeza, Marcelo; Universidad de Chile. Facultad de Ciencias. Departamento de Ciencias Ecológicas. Santiago. CL
  • Cifuentes, Víctor; Universidad de Chile. Facultad de Ciencias. Departamento de Ciencias Ecológicas. Santiago. CL
  • Alcaíno, Jennifer; Universidad de Chile. Facultad de Ciencias. Departamento de Ciencias Ecológicas. Santiago. CL
Biol. Res ; 54: 34-34, 2021. ilus, tab
Article en En | LILACS | ID: biblio-1505790
Biblioteca responsable: CL1.1
ABSTRACT
Xanthophyllomyces dendrorhous is a basidiomycete yeast that naturally produces the red-orange carotenoid astaxanthin, which has remarkable antioxidant properties. The biosynthesis of carotenoids and sterols share some common elements that have been studied in X. dendrorhous. For example, their synthesis requires metabolites derived from the mevalonate pathway and in both specific pathways, cytochrome P450 enzymes are involved that share a single cytochrome P450 reductase, CrtR, which is essential for astaxanthin biosynthesis, but is replaceable for ergosterol biosynthesis. Research on the regulation of carotenoid biosynthesis is still limited in X. dendrorhous; however, it is known that the Sterol Regulatory Element-Binding Protein (SREBP) pathway, which is a conserved regulatory pathway involved in the control of lipid metabolism, also regulates carotenoid production in X. dendrorhous. This review addresses the similarities and differences that have been observed between mammal and fungal SREBP pathways and what it is known about this pathway regarding the regulation of the production of carotenoids and sterols in X. dendrorhous.
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Texto completo: 1 Base de datos: LILACS Asunto principal: Basidiomycota / Proteínas de Unión a los Elementos Reguladores de Esteroles Idioma: En Revista: Biol. Res Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Chile

Texto completo: 1 Base de datos: LILACS Asunto principal: Basidiomycota / Proteínas de Unión a los Elementos Reguladores de Esteroles Idioma: En Revista: Biol. Res Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Chile