Inhibition of thymocyte positive selection by natural MHC: peptide ligands.
Eur J Immunol
; 29(2): 394-402, 1999 02.
Article
en En
| MEDLINE
| ID: mdl-10064054
ABSTRACT
The 3A9 transgenic mouse line carries the rearranged TCR genes from a T cell hybridoma that recognizes hen egg lysozyme peptide 46-61 in the context of MHC class II Ak molecules. As expected, positive selection of immature 3A9 thymocytes to become mature CD4+ 8- T cells was efficient on the "selecting" CBA (H-2k) genetic background but not on the "non-selecting" C57BL/6 (H-2b) background. Surprisingly, positive selection was also inefficient on the CBA x C57BL/6 F1 background (H-2kb). We present evidence that expression of A(beta)b molecules on thymus epithelium (in conjunction with A(alpha)b or A(alpha)k molecules) inhibits the positive selection of 3A9 thymocytes mediated by A(alpha)kA(beta)k complexes, in a process evocative of peptide antagonism of mature T cells.
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Base de datos:
MEDLINE
Asunto principal:
Antígenos de Histocompatibilidad Clase II
/
Receptores de Antígenos de Linfocitos T alfa-beta
Límite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Año:
1999
Tipo del documento:
Article
País de afiliación:
Francia