In vivo visualization of serotonin transporters in the human brain during fluoxetine treatment.
Eur Neuropsychopharmacol
; 9(1-2): 177-9, 1999 Jan.
Article
en En
| MEDLINE
| ID: mdl-10082245
ABSTRACT
Beta-CIT can be used as a tracer for SPECT to visualize serotonin transporters in the human brain. We present a case of bulimia nervosa and major depressive disorder, who had been treated with up to 60 mg/d fluoxetine for several weeks. Four hours after injection of the tracer more than 40% of serotonin transporters were blocked. To our knowledge, this is the first direct documentation of the pharmacodynamic action of fluoxetine in the human brain in vivo.
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Base de datos:
MEDLINE
Asunto principal:
Proteínas de Transporte de Membrana
/
Encéfalo
/
Química Encefálica
/
Glicoproteínas de Membrana
/
Proteínas Portadoras
/
Fluoxetina
/
Antidepresivos de Segunda Generación
/
Proteínas del Tejido Nervioso
Límite:
Adolescent
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Eur Neuropsychopharmacol
Asunto de la revista:
PSICOFARMACOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Austria