The HDL receptor SR-BI: a new therapeutic target for atherosclerosis?
Mol Med Today
; 5(12): 518-24, 1999 Dec.
Article
en En
| MEDLINE
| ID: mdl-10562717
ABSTRACT
Although high-density lipoprotein (HDL) metabolism is a crucial process for cholesterol homeostasis and coronary heart disease, therapeutic approaches for selective modification of plasma HDL levels are not currently available. The discovery of well-defined cell-surface HDL receptors should provide new avenues for treatment of atherosclerotic cardiovascular disease. In fact, SR-BI, a recently identified receptor for selective HDL cholesterol uptake, is relevant for physiological processes (for example, HDL metabolism, steroidogenesis and biliary cholesterol secretion) and pathophysiological conditions (for example, atherosclerosis) in animal models. If SR-BI has similar activities in humans, it might represent a new therapeutic target for atherosclerosis.
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Base de datos:
MEDLINE
Asunto principal:
Arteriosclerosis
/
Receptores Inmunológicos
/
Proteínas Portadoras
/
Proteínas de Unión al ARN
/
Receptores de Lipoproteína
/
Antígenos CD36
/
Lipoproteínas HDL
/
Proteínas de la Membrana
Límite:
Humans
Idioma:
En
Revista:
Mol Med Today
Asunto de la revista:
BIOLOGIA MOLECULAR
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos