Elevated prolactin in pediatric patients on typical and atypical antipsychotics.
J Child Adolesc Psychopharmacol
; 9(4): 239-45, 1999.
Article
en En
| MEDLINE
| ID: mdl-10630453
ABSTRACT
As part of systematic treatment trials of haloperidol, clozapine, and olanzapine with a total of 35 children and adolescents with early onset psychosis, prolactin was measured at baseline and week 6 of treatment. The National Institute of Mental Health patients--13 females, 22 males (mean age, 14.1+/-2.3 years; range, 9.1-19 years) with childhood onset schizophrenia (n = 32), or Psychotic Disorder not otherwise specified (NOS) (n = 3) with onset of psychosis before age 13--were recruited for open or double-blind trials of haloperidol, clozapine, or olanzapine. Baseline serum prolactin was measured after a 3-week washout period and after 6 weeks of treatment. Mean prolactin concentration after 6 weeks of treatment was significantly elevated on all three drugs; however, on clozapine, mean prolactin remained within the normal range. Prolactin was increased above the upper limit of normal for 100% of 10 patients on haloperidol, 70% of 10 patients on olanzapine, and 0% of 15 patients on clozapine (chi2 analyses H > C, p = 0.004; O > C, p = 0.001). Given the potential endocrine and possible cardiac correlates of hyperprolactinemia, these more robust prolactin elevations in pediatric patients after short-term exposure to olanzapine than those reported for adults justify longer observation intervals with bigger samples to establish treatment safety of atypical antipsychotics in adolescents.
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Base de datos:
MEDLINE
Asunto principal:
Prolactina
/
Antipsicóticos
/
Pirenzepina
/
Clozapina
/
Haloperidol
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Child Adolesc Psychopharmacol
Asunto de la revista:
PEDIATRIA
/
PSICOFARMACOLOGIA
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos