Peripheral plasma amino acid abnormalities in rehabilitation patients with severe brain injury.
Arch Phys Med Rehabil
; 81(2): 176-81, 2000 Feb.
Article
en En
| MEDLINE
| ID: mdl-10668771
ABSTRACT
OBJECTIVE:
Acute severe brain injury causes an increased mobilization of amino acids from tissue. The plasma amino acid profile of patients undergoing rehabilitation after brain injury is unknown. This study was aimed at delineating the plasma amino acid profile of rehabilitation patients with brain injury.DESIGN:
Peripheral plasma aminogram, lactate, pyruvate, glycerol, ketone body, and carnitine concentrations were determined in 11 patients with brain injury (34.6+/-15 years old, 60+/-16.8 days after injury) and in 8 controls. Resting energy expenditure and nitrogen balance were also determined.RESULTS:
(1) All essential amino acids and about 50% of nonessential amino acids were significantly lower in brain injury patients than in controls (p < .05). (2) Plasma amino acids were lower irrespective of either energy and protein intake or nitrogen balance. (3) Total carnitine concentration and esterified/free carnitine ratio were higher in brain injury patients than in controls (p < .05).CONCLUSIONS:
Rehabilitation patients with brain injury may have an important reduction of their plasma aminogram. Muscle tissue depletion and the persistence of a hypercatabolic state caused by subclinical infections, pressure sores, and immobility may contribute to this reduction.
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Base de datos:
MEDLINE
Asunto principal:
Lesiones Encefálicas
/
Aminoácidos
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Arch Phys Med Rehabil
Año:
2000
Tipo del documento:
Article
País de afiliación:
Italia