Usefulness of screening for congenital or acquired hemostatic abnormalities in women with previous complicated pregnancies.
Haemostasis
; 29(4): 197-203, 1999.
Article
en En
| MEDLINE
| ID: mdl-10702700
ABSTRACT
Activated protein C resistance (APCR) is a common cause of familial thrombophilia and venous thrombosis. The aim of the study was to investigate the prevalence of APCR associated with factor V Leiden mutation and its relevance in comparison to other risk factors for thromboembolic disorders in women with a history of previous complicated pregnancies (history of fetal loss in the second and third trimester n = 34, preeclampsia n = 46). The frequency of APCR was significantly higher in women with a history of fetal loss and preeclampsia (23.5 and 26.1%, respectively) compared with a control group (3.8%). The prevalence of antithrombin, protein C and protein S deficiencies and the presence of antiphospholipid antibodies were also investigated the prevalence of at least one disorder was 41.2% in the group with previous fetal loss, 37.0% in the group with previous preeclampsia and 7.5% in the control group.
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Base de datos:
MEDLINE
Asunto principal:
Trastornos de la Coagulación Sanguínea
/
Hemostáticos
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
País/Región como asunto:
Europa
Idioma:
En
Revista:
Haemostasis
Año:
1999
Tipo del documento:
Article
País de afiliación:
Italia