Cathepsin D expression in early cutaneous malignant melanoma.
Int J Dermatol
; 39(8): 599-602, 2000 Aug.
Article
en En
| MEDLINE
| ID: mdl-10971728
ABSTRACT
BACKGROUND:
The aspartic proteinase cathepsin D is believed to be associated with proteolytic processes leading to the invasion and seeding of tumor cells. An association between cathepsin D tissue concentration and aggressiveness of tumors has been detected in different cancer types, as well as in metastatic melanoma.METHODS:
The concentration of cathepsin D was measured immunoradiometrically (ELSA-CATH-D kit, CIS Bio International) in the cytosols of 51 primary cutaneous melanomas (with Breslow index < 4 mm) to estimate the tissue concentrations of cathepsin D in early cutaneous melanoma.RESULTS:
A significantly elevated concentration of cathepsin D was measured in the tumor cytosols as compared to adjacent normal tissue (44.2 vs. 14.7 pmol/mg of total protein, P < 0.001).CONCLUSIONS:
Our results indicate that cathepsin D is expressed at high levels by melanoma cells. The extremely high expression of cathepsin D in two of our patients, with later progression of the disease over a 42-month follow-up period, suggests a possible correlation between the cathepsin D tissue concentration and the prognosis of primary cutaneous malignant melanoma.
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Base de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Catepsina D
/
Melanoma
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Dermatol
Año:
2000
Tipo del documento:
Article
País de afiliación:
Eslovenia