Increased leukocyte aggregation induced by gamma-globulin: a clue to the presence of pseudoleukopenia.
Am J Med Sci
; 320(3): 177-82, 2000 Sep.
Article
en En
| MEDLINE
| ID: mdl-11014371
ABSTRACT
BACKGROUND:
Previous articles have reported the appearance of leukopenia after the administration of high-dose intravenous gamma-globulins.METHODS:
A simple slide test was used to reveal the state of leukocyte aggregation (LA) in the peripheral blood as well as the absolute number of leukocytes in the slides.RESULTS:
A significant (P < 0.00001) increment was noted in the state of LA, from 9 +/- 6% before to 25 +/- 11% after gamma-globulin administration. This was accompanied by a significant (P < 0.0004) reduction in the number of white blood cells in the peripheral blood (from 8433 +/- 3905 to 6550 +/- 3252 cells/mm3) but no significant change in the absolute number of the cells as determined by the leukocyte count per high power field in the peripheral slides.CONCLUSIONS:
We raise the possibility that the leukopenia reported in some patients after the intravenous administration of high dose gamma-globulin is explained in part by the agglutination effect of the drug.
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Base de datos:
MEDLINE
Asunto principal:
Gammaglobulinas
/
Agregación Celular
/
Leucocitos
/
Leucopenia
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Med Sci
Año:
2000
Tipo del documento:
Article
País de afiliación:
Israel