Two translocations of chromosome 15q associated with dyslexia.
J Med Genet
; 37(10): 771-5, 2000 Oct.
Article
en En
| MEDLINE
| ID: mdl-11015455
ABSTRACT
Developmental dyslexia is characterised by difficulties in learning to read. As reading is a complex cognitive process, multiple genes are expected to contribute to the pathogenesis of dyslexia. The genetics of dyslexia has been a target of molecular studies during recent years, but so far no genes have been identified. However, a locus for dyslexia on chromosome 15q21 (DYX1) has been established in previous linkage studies. We have identified two families with balanced translocations involving the 15q21-q22 region. In one family, the translocation segregates with specific dyslexia in three family members. In the other family, the translocation is associated with dyslexia in one family member. We have performed fluorescence in situ hybridisation (FISH) studies to refine the position of the putative dyslexia locus further. Our results indicate that both translocation breakpoints on 15q map within an interval of approximately 6-8 Mb between markers D15S143 and D15S1029, further supporting the presence of a locus for specific dyslexia on 15q21.
Texto completo:
1
Base de datos:
MEDLINE
Asunto principal:
Translocación Genética
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Cromosomas Humanos Par 15
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Dislexia
Tipo de estudio:
Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
J Med Genet
Año:
2000
Tipo del documento:
Article
País de afiliación:
Finlandia