[Effect of heparin cofactor II on the antithrombin III activities measured by thrombin methods or factor Xa methods--fundamental studies and clinical studies using the plasma of pregnant women].
Rinsho Byori
; 48(9): 867-71, 2000 Sep.
Article
en Ja
| MEDLINE
| ID: mdl-11051806
ABSTRACT
We evaluated the effects of heparin cofactor II(HC II) on the antithrombin III(AT III) activities measured by the methods of thrombin or factor Xa. Reagents A and B were using the method of thrombin and reagent C was based on the method of Xa. Purified HC II was directly measured or indirectly measured after the dilution with control plasma. Cross reaction of HC II in AT III assay were negligible in reagent C, but substantial amount of AT III activities were measured in reagent A and B. Plasma AT III activities from full-term pregnant women were significantly higher than those from non pregnant control women in reagent A, but comparable in reagent B or C. These results indicate that AT III activities measured by thrombin methods by thrombin were overestimated in pregnant women due to the cross-reactivities of HC II. It is recommended that AT III activities would be measured by the methods of factor Xa.
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Base de datos:
MEDLINE
Asunto principal:
Pruebas de Coagulación Sanguínea
/
Cofactor II de Heparina
/
Antitrombina III
Tipo de estudio:
Evaluation_studies
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
Ja
Revista:
Rinsho Byori
Año:
2000
Tipo del documento:
Article