A benzodiazepine hypnotic facilitates adaptation of circadian rhythms and sleep-wake homeostasis to an eight hour delay shift simulating westward jet lag.
Sleep
; 23(7): 915-27, 2000 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-11083601
ABSTRACT
STUDY OBJECTIVES:
To determine whether appropriately timed administration of a short-acting benzodiazepine hypnotic, which has proven effective in an animal model of jet lag, also facilitates adaptation of circadian rhythmicity and sleep-wake homeostasis in a human model of jet lag.DESIGN:
Subjects participated in two double-blind, placebo-controlled studies of adaptation to an 8-hr delay shift of sleep-wake and dark-light cycles simulating westward travel. Each 9-day laboratory study began with a 3-day habituation period followed by a 24-hr study to obtain basal hormonal and sleep profiles (2300-0700). Subjects were then kept awake until 0700 the next day and slept in darkness 0700-1500 for the next five 24-hr spans post-shift.SETTING:
N/A.PARTICIPANTS:
6 normal, healthy men 24-31 years of age.INTERVENTIONS:
Oral Triazolam (0.5 mg) or placebo given at 0400 before the first shifted sleep/dark period (3 hours before bedtime) and at 0700 (at bedtime) on days 2-5 post-shift. MEASUREMENTS ANDRESULTS:
Sleep recordings and 24-hr cortisol and growth hormone profiles were obtained at baseline and on the first, third, and fifth days post-shift. Global measures of treatment efficacy were calculated for multiple endpoints representing circadian rhythmicity and sleep-wake homeostasis. With placebo, the shift induced disturbances of sleep and hormonal secretion, and a gradual re-entrainment of circadian rhythmicity. Triazolam significantly facilitated adaptation by accelerating re-entrainment of circadian rhythms (chronobiotic effect) and normalizing markers of sleep/wake homeostasis (hypnotic effect).CONCLUSIONS:
Appropriately timed administration of a benzodiazepine hypnotic appears to facilitate the adaptation of both circadian rhythmicity and sleep-wake homeostasis to a shifted dark/sleep cycle. Compounds with combined chronobiotic/hypnotic properties may be useful in conditions of jet lag or night work.
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Base de datos:
MEDLINE
Asunto principal:
Ansiolíticos
/
Triazolam
/
Adaptación Fisiológica
/
Ritmo Circadiano
/
Trastornos del Sueño del Ritmo Circadiano
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Límite:
Adult
/
Humans
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Male
Idioma:
En
Revista:
Sleep
Año:
2000
Tipo del documento:
Article
País de afiliación:
Estados Unidos